Navigation Links
Predicting higher risk for prostate cancer diagnosis
Date:5/26/2009

High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. Research published in the open access journal BMC Urology has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.

Paras Singh and Francis Martin, from Lancashire Teaching Hospitals NHS Foundation Trust and Lancaster University, along with their co-workers, conducted a retrospective analysis of the institution's pathology database, investigating the occurrence of prostate cancer in patients initially diagnosed with HGPIN. They also calculated the risk of developing prostate cancer based on initial levels of PSA. They said, "Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 prostate cancer diagnoses were made. Age at first biopsy, higher baseline PSA and higher change in PSA were all predictive of cancer detection on repeat biopsies".

There has been speculation that an initial diagnosis of HGPIN may not be a useful indicator of the future risk of prostate cancer. The authors acknowledge that the 41.8% risk they identified is higher than that found by most contemporary studies, but point out that it is comparable to an earlier US-based study from when there was lower level of PSA screening, perhaps similar to the current situation in the UK.

The researchers conclude, "HGPIN carries a high predictive value for future diagnosis of prostate cancer. Based on our results, we recommend delaying the first repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-787-741-1853
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Use of certain lipid measures not more effective in predicting coronary heart disease
2. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
3. Predicting survival after liver transplantation
4. Predicting the future in ovarian cancer
5. Predicting post-traumatic stress disorders in deployed veterans
6. Research highlights problems of predicting birthweights in obese mothers
7. Prototype test for predicting clinical outcome for melanoma patients
8. Novel imaging approach may assist in predicting success of treatment for atrial fibrillation
9. Predicting the future for patients with severe traumatic brain injury
10. Genetic Testing No Real Help in Predicting Type 2 Diabetes
11. Researchers discover strategy for predicting the immunity of vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 19, 2014 SuperCloset raises the bar ... SuperCloset continues to offer indoor growers the most efficient ... the new SuperClone Rooms with the award winning ... indoor hydroponic grow room setup. , The SuperClone Room ... SuperPonic SuperCloner 50 . The SuperClone ...
(Date:12/19/2014)... December 20, 2014 The Medspa at ... injectable filler from respected cosmetic brand Juvéderm. Voluma XC ... with age. The Medspa at Hendrick is pleased to ... skin care technology to its clients. , Voluma is ... be FDA-approved to treat the mid-face and cheek area. ...
(Date:12/19/2014)... 2014 (HealthDay News) -- All children should have their ... preferably every year, eye experts say. The new ... panel of the U.S. National Center for Children,s Vision ... age group require screening for eye problems, particularly vision ... amblyopia ("lazy eye") and strabismus (a disorder of eye ...
(Date:12/19/2014)... 19, 2014 (HealthDay News) -- The cost of cancer ... a new study finds. Researchers examined data from ... diagnosed with colorectal or lung cancer. Of those patients, ... and more than 100 had advanced cancer. Nearly ... pay their medical bills, which was linked with a ...
(Date:12/19/2014)... Dennis Thompson HealthDay Reporter ... Ebola,s entrance into the United States -- along with ... outbreak -- have highlighted cracks in the nation,s public ... health policy report released Thursday. Half of U.S. ... to infectious disease outbreaks. That was the main conclusion ...
Breaking Medicine News(10 mins):Health News:SuperCloset Continues to Innovate with New Complete Indoor Grow Room Packages, The SuperClone Rooms are the Newest Addition to the Award Winning SuperRoom Lineup 2Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2Health News:Preschoolers Need Eye Screening, Experts Say 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 2Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 3Health News:Most States Not Ready to Handle Infectious Disease Outbreaks: Report 4
... NEW YORK, Oct. 9 You may not ... if, according to health experts, you get your ... vaccinated against the virus that causes,36,000 deaths annually. ... http://media.medialink.com/WebNR.aspx?story=33948 Registered journalists can access video, ...
... ANGELES, Oct. 9 Elvira, Mistress of the,Dark, will ... dance party fundraiser benefiting AIDS Healthcare Foundation.,This wicked-cool event ... thrift,store in Hollywood at 6210 West Sunset Blvd. on ... 2007, will feature a fashion show and contest,highlighting the ...
... Tissue Donor Registry Reaches 2 ... Million Registrations ... SACRAMENTO, Calif., Oct. 9 More than two million,Californians have signed up ... & Tissue Donor Registry, doubling the,state,s number of designated donors in only ...
... House Republican Whip Roy,Blunt (Mo.) issued the following ... yesterday suggested on CNN that Democrats wouldn,t,be able ... veto of the,SCHIP bill:, "Yesterday, the House ... override the president,s veto of a bill that ...
... crossword-puzzle solver who uses the letters in some answers ... and an international group of collaborators have used data ... to identify a gene linked to non-hereditary cases of ... posted online by the journal Nature Genetics, didnt require ...
... Actor Joe Pantoliano,reveals a personal history of depression ... bipolar disorder, in a guest blog entry, http://www.nami.org/blog ... Mental,Illness (NAMI)., Pantoliano,s entry comes during Mental ... before the opening of his latest film, CANVAS, ...
Cached Medicine News:Health News:'Something Wicked!' This Way Comes: Elvira Hosts Halloween Fashion Show and Fundraiser Benefiting AIDS Healthcare Foundation 2Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 2Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 3Health News:Two Million Californians Say 'Yes!' to Organ and Tissue Donation 4Health News:'Network' approach identifies potential breast cancer susceptibility gene 2Health News:'Network' approach identifies potential breast cancer susceptibility gene 3Health News:'Network' approach identifies potential breast cancer susceptibility gene 4Health News:Actor Joe Pantoliano Discloses Depression; Talks About His Latest Movie and His Sensitive Side 2
(Date:12/17/2014)... YORK , Dec. 17, 2014 ... imaging (MRI), the MRI market is seeing new ... and breast MRI scans account for the majority ... a higher resolution of images, which are creating opportunities ... imaging (MRI) market is growing at a rate ...
(Date:12/17/2014)... MILAN , December 17, 2014 ... becoming nothing less than a hub of information concerning the ... A further addition to the recently launched ... world and has now been enriched by a new chapter ... A richly detailed and panoramic hub on ...
(Date:12/17/2014)... 17, 2014  IGI Laboratories, Inc. (NYSE MKT: IG; ... its offering of $125 million aggregate principal amount of ... Notes were offered and sold only to qualified institutional ... of 1933, as amended (the "Securities Act"). ... 3.75% per year, payable semiannually in arrears on June ...
Breaking Medicine Technology:Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... ROCKVILLE, Md., Jan. 31, 2011 To further its ... manufacturers, the U.S. Pharmacopeial Convention (USP) has appointed Mr. ... Sao Paulo, Brazil facility. USP is a scientific nonprofit ... people around the world through standards and related programs ...
... 31, 2011 Global Real Estate Consultants has helped ... new facility in Fremont. Global Real ... insight and transparency in the Fremont commercial real estate ... 350,000 sq. ft. state-of-the-art manufacturing facility with pilot plant ...
Cached Medicine Technology:New Interim Leadership for USP-Brazil 2Boehringer Ingelheim to Purchase Amgen's Fremont (USA) Facility 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: