Navigation Links
Predicting higher risk for prostate cancer diagnosis
Date:5/26/2009

High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. Research published in the open access journal BMC Urology has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.

Paras Singh and Francis Martin, from Lancashire Teaching Hospitals NHS Foundation Trust and Lancaster University, along with their co-workers, conducted a retrospective analysis of the institution's pathology database, investigating the occurrence of prostate cancer in patients initially diagnosed with HGPIN. They also calculated the risk of developing prostate cancer based on initial levels of PSA. They said, "Of 2,192 biopsied patients, there were 88 cases of isolated HGPIN of which 67 patients underwent one or more repeat biopsies. In this repeat-biopsy group, 28 prostate cancer diagnoses were made. Age at first biopsy, higher baseline PSA and higher change in PSA were all predictive of cancer detection on repeat biopsies".

There has been speculation that an initial diagnosis of HGPIN may not be a useful indicator of the future risk of prostate cancer. The authors acknowledge that the 41.8% risk they identified is higher than that found by most contemporary studies, but point out that it is comparable to an earlier US-based study from when there was lower level of PSA screening, perhaps similar to the current situation in the UK.

The researchers conclude, "HGPIN carries a high predictive value for future diagnosis of prostate cancer. Based on our results, we recommend delaying the first repeat biopsy at low PSA range but to have a shorter interval to repeat biopsies at intermediate and higher PSA ranges".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-787-741-1853
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Use of certain lipid measures not more effective in predicting coronary heart disease
2. Blood test takes step toward predicting Alzheimers risk, Stanford researchers find
3. Predicting survival after liver transplantation
4. Predicting the future in ovarian cancer
5. Predicting post-traumatic stress disorders in deployed veterans
6. Research highlights problems of predicting birthweights in obese mothers
7. Prototype test for predicting clinical outcome for melanoma patients
8. Novel imaging approach may assist in predicting success of treatment for atrial fibrillation
9. Predicting the future for patients with severe traumatic brain injury
10. Genetic Testing No Real Help in Predicting Type 2 Diabetes
11. Researchers discover strategy for predicting the immunity of vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... Fla. (PRWEB) , ... May 03, 2016 , ... Elizabeth ... her pet parrots to join her with one on her shoulder and one on ... through a parking lot because of years of mitral valve prolapse. , The valves ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... has been selected by Tidelands Health, a three hospital system in South Carolina, ... constantly on the lookout for technology that enhances communication, drives workflow efficiencies and ...
(Date:5/3/2016)... ... May 03, 2016 , ... Each year, about 800,000 people ... death across the United States and account for one death every four minutes. ... are permanently disabled. HCR ManorCare is launching a video series called “Your Brain,” in ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... industry, announced today that Legacy Health is expanding its use of Intrigma’s cloud-based ... a highly successful initial proof of concept. The Portland, Oregon based health system ...
(Date:5/3/2016)... ... May 03, 2016 , ... Huntington Beach orthopedic doctor ... surgical procedure that can be used to diagnose and treat joint problems. During this ... These instruments include a special lighting system and lens that illuminate and magnify the ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... SAN FRANCISCO , May 2, 2016 /PRNewswire/ ...  is expected to reach USD 11.1 billion by ... Grand View Research, Inc. Major drivers of the ... in therapeutic areas and government recommendations for periodic ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
(Date:4/29/2016)... 29, 2016 ReportsnReports.com adds ... market research report that provides an overview of ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ... key players involved in the therapeutic development for ...
(Date:4/29/2016)... , April 29, 2016 /PRNewswire/ ... Contamine, Directeur Financier Sanofi, ... santé, publie ses résultats pour le ... du Groupe, Jérôme Contamine, commente les ... et les perspectives pour le reste ...
Breaking Medicine Technology: