Navigation Links
Preclinical study suggests organ-transplant drug may aid in lupus fight
Date:8/15/2007

DALLAS Aug. 15, 2007 A compound related to a drug used in humans to prevent organ-transplant rejection attacks a key biochemical process in the faulty immune cells of lupus-prone mice, suggesting a possible new approach to combating the disease, UT Southwestern Medical Center researchers have found.

We found that an analog of rapamycin is very effective in improving all aspects of the disease in lupus-prone mice, said Dr. Chandra Mohan, professor of internal medicine and senior author of a study appearing in the August issue of the Journal of Clinical Investigation. Our next step will be to see if the same biochemical pathways exist in humans. If they do, this research and treatment could prove very significant.

Lupus is a chronic autoimmune disease in which the immune system attacks the bodys cells and tissues. In a normal immune system, foreign intruders are recognized by special immune cells called B-cells, which produce antibodies. In patients with lupus, however, the antibodies created by the B-cells start to attack the body itself.

Certain genetic strains of mice are prone to developing lupus. In the current study, a research team led by Dr. Mohan discovered that an analog of rapamycin shuts down specific biochemical processes in the B-cells of the mice. Rapamycin has been used in humans to prevent organ transplant rejection and for treating cancer. The analog of rapamycin halted production of antibodies and the development of lupus in all the strains of lupus-prone mice, as well as improved symptoms, despite each animal having a different genetic makeup that led to the disease.

Though lupus in different mouse models may originate from different genetic triggers, those triggers ultimately funnel through a shared series of biochemical pathways that lead to the disease, Dr. Mohan said. These shared biochemical pathways represent an attractive target for future therapeutic intervention in lupus patients.

In humans, lupus can cause life-threatening damage to the kidneys, lungs, heart, central nervous system, joints, blood vessels and skin. It can be associated with severe fatigue, joint pain, skin rashes, hair loss and neurological problems. Although treatable symptomatically, there is currently no cure for the disease, which affects up to 1 million people in the U.S.


'/>"/>

Contact: Erin Prather Stafford
erin.pratherstafford@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test
2. Gene study links endometriosis, infertility
3. Study reveals how stress can make you sick
4. Study points out that HIV vaccine may not be accepted easily
5. A new study surpasses Gene Therapy Hurdle
6. Tomato Sauce reduces Cancer Risk- Study
7. A question on study of Adult Stem Cell
8. Study on obesity and heart failure
9. National Lung Study in the process
10. Marijuana gateway theory strengthened by study of twins
11. Old theory of adaptation confirmed by new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... in a medical capacity this year. Drs. Alexander Paziotopoulos, Andrew Petersen and Trish ... a condensed version of the clinic’s leading recovery program. , “We know ...
(Date:1/19/2017)... ... 19, 2017 , ... Bio-Optronics Inc. is proud to announce ... designed to seamlessly integrate and streamline the way researchers prepare and conduct patient ... usability and improving efficiency significantly for users – a first in the CTMS ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... panel system. , The Tranquility privacy panel system was designed to deliver ... Tranquility panels help reduce noise and provide the visual privacy required to maintain ...
(Date:1/19/2017)... ... January 19, 2017 , ... Rountree ... planning services to communities throughout eastern Georgia, is embarking on a charity effort ... Heart disease kills more Americans every year than anything else, yet risk factors ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Attorney Robert ... fifth consecutive year donated money to the Triumph Over Kid Cancer foundation. Each year, ... one of those children. James saw firsthand the effect of the critical funding gap ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... and Markets has announced the addition of the "Vital Signs Monitoring ... Industry Forecast, 2014-2022" report to their offering. ... Vital signs monitoring market size was worth $3,694 ... growing at a CAGR of 5.8% from 2016 to 2022. ... in global vital signs monitoring devices industry. The blood pressure monitoring devices ...
(Date:1/18/2017)... SAN JOSE, Calif. , Jan. 18, 2017  Adaptive ... machines, announced today a new partnership with Hyatt Place ... guests by providing ASTI LectroFan sleep therapy machines in ... "Obviously one of the most important parts of having ... Wicks , general manager of Hyatt Place Nashville/Downtown. "We,re ...
(Date:1/18/2017)... LITTLE FALLS, N.J. , Jan. 18, 2017 /PRNewswire/ ... RGIN ), a biotechnology company specializing in the development ... health of damaged tissues and organs, recently reported the ... key milestones for 2017. As the Company ... 2016 has been a year of substantial accomplishments. The ...
Breaking Medicine Technology: