Navigation Links
Preclinical study identifies 'master' proto-oncogene that regulates ovarian cancer metastasis
Date:1/29/2013

n patients treated with a beta blocker was reduced by an average of 17 percent across all major cancer types. Moreover, they observed a nearly 15 percent decrease in mortality among patients with ovarian and cervical cancer.

Beta blockers, also called beta-adrenergic blocking agents, treat a variety of conditions, such as heart disease, high blood pressure, glaucoma and migraines. They act on the ADRB receptors, which are also found on the heart causing the heart to beat harder and faster under stress and are involved in maintaining blood flow.

When the ADRB receptors on cancer cells are activated, they set into motion a chain of events that leads to formation of new blood vessels that feed tumor growth a process known as angiogenesis. New blood vessel formation allows tumors to grow and spread more rapidly. Beta blocking agents stop this process.

"Prior to our work, the concept of stress hormones driving cancer growth was very new and only very limited information about the effect of beta blockers on cancer outcomes in humans has been available," said Guillermo Armaiz-Pena, Ph.D., instructor of Gynecologic Oncology and Reproductive Medicine and first author of the study. "This study provides incentive to further explore beta blockers as a possible supplement to traditional cancer therapies."

A Mystery Pathway Revealed

While NA the most abundant stress hormone in the ovary has been proven to modulate multiple cellular functions important for cancer progression, how it does so had remained a puzzle. Sood's team used a multi-step process to determine how the tumor microenvironment is disrupted by stress hormones.

First, the researchers exposed ovarian cancer cells to NA and identified a number of proteins altered by stress hormones. Using bioinformatics analysis, they narrowed potential mediators to Src.

A series of subsequent experiments designed to verify the biological roles of Src in promotin
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Genetically-engineered preclinical models predict pharmacodynamic response
2. Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
3. BUSM study highlights attitudes toward HPV vaccination for boys
4. Study reveals 2-fold higher incidence of non-melanoma skin cancers for HIV patients
5. 1 in 5 Hospital Docs Reports Unsafe Workloads: Study
6. Coming Out Can Bring Health Benefits, Study Says
7. Study: Lungs From Heavy Smokers OK for Transplant
8. Early menopause may occur in women with BRCA gene, new study finds
9. Study demonstrates health benefits of coming out of the closet
10. No Proof Drugs Ease Kids Migraines: Study
11. Fried Foods May Boost Prostate Cancer Risk, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... 2014: Digoxin may increase the risk of death in ... to results from the ROCKET AF trial presented at ... interventional cardiology and catheterisation labs at Duke University Health ... that caution may be needed when using digoxin in ... confirm the observations. , Dr Patel said: "In this ...
(Date:9/2/2014)... September 2014: The fact that mechanical heart valves increase ... data from the ROPAC registry presented for the first ... by Professor Jolien W. Roos-Hesselink, co-chair with Professor Roger ... that 1.4% of pregnant women with a mechanical heart ... , The Registry Of Pregnancy And Cardiac disease (ROPAC) ...
(Date:9/2/2014)... Aeroflow Healthcare, an industry leader and home ... opening of its new office to be located in ... Parkway, Suite D, Greer, SC 29651. This new location ... more convenient location in the Greenville area. , “This ... physicians, hospitals and patients we serve, to ensure that ...
(Date:9/2/2014)... Attorney Robert M. Higgins has been named by ... Medical Malpractice Law - Plaintiffs. Higgins is a ... selected for inclusion in The Best Lawyers in America each ... and designated metropolitan area is honored as the “Lawyer of ... the peer-review assessments. , The Best Lawyers ...
(Date:9/2/2014)... Productive Dentist Academy, a dental marketing ... been named to Inc. Magazine’s 5000 list for fastest-growing ... year in a row it has obtained this distinction. ... percent growth rate and increased revenues from $1.9 million ... number of employees from eight to 25. All of ...
Breaking Medicine News(10 mins):Health News:ROCKET AF trial suggests that digoxin increases risk of death in AF patients 2Health News:Mechanical heart valves increase pregnancy risk 2Health News:Mechanical heart valves increase pregnancy risk 3Health News:Aeroflow Healthcare Opens Office In Greer, SC To Service Greenville & Spartanburg Patients 2Health News:Robert Higgins Named 2015 Best Lawyers® "Lawyer of the Year" in Boston 2Health News:Dental Management Company Named to Fastest-Growing List Again 2Health News:Dental Management Company Named to Fastest-Growing List Again 3
... 20 Purdue Pharma L.P. and Mundipharma International Corporation ... global strategic alliance with Infinity Pharmaceuticals, Inc. to advance ... early clinical programs in the areas of oncology and ... The alliance will focus on supporting Infinity,s ...
... Healthplace America is pleased to,introduce Surgery Benefit Management ... the Healthplace Benefit(TM), is the first and only,comprehensive ... employer health plans while enhancing employee benefits with ... Surgery accounts for $700 billion ...
... in the field of,implant dentistry about proper use of ... the shorter, less costly procedure while others advocate a,more ... to the American Academy of Implant Dentistry (AAID), http://www.aaid.com ... also have been raised about whether general dentists who ...
... (Terry) Fontham, MPH, DrPH, Dean of the LSU Health Sciences Center ... elected national President of the American Cancer Society when she is ... on November 20, 2008 in New York City. She will ... as president in the organization,s 96-year history., ...
... Lets Terminally Ill Vietnam Veteran Regain Mobility and Independence , ... Tough odds have never stopped Anthony Radonski. He has survived the ... lymphoma. Immobility, though, has tested the 60-year-old war hero,s spirit like ... free power wheelchair to him. , ...
... Allscripts,today announced that Kindred Healthcare, Inc., the nation,s ... Referral Management,Plus to help manage and coordinate patient ... and 228 nursing and rehabilitation,centers across the nation. ... http://www.newscom.com/cgi-bin/prnh/20081013/AQM041LOGO ) , ...
Cached Medicine News:Health News:Purdue Pharma L.P. Announces a Global Strategic Alliance With Infinity Pharmaceuticals to Advance Discovery and Development Programs in Oncology and Neuropathic Pain 2Health News:Healthplace America Delivers the First and Only Surgery Benefit Management Solution Through the Healthplace Benefit(TM) 2Health News:Healthplace America Delivers the First and Only Surgery Benefit Management Solution Through the Healthplace Benefit(TM) 3Health News:Use of Mini Dental Implants on the Rise but Questions Linger 2Health News:Use of Mini Dental Implants on the Rise but Questions Linger 3Health News:LSUHSC's Fontham makes history 2Health News:LSUHSC's Fontham makes history 3Health News:The SCOOTER Store Donates Power Wheelchair to California War Hero, a Purple Heart Recipient 2Health News:The SCOOTER Store Donates Power Wheelchair to California War Hero, a Purple Heart Recipient 3Health News:Kindred Healthcare, Nation's Largest Post-Acute Healthcare Provider, Selects Allscripts Referral Management 2Health News:Kindred Healthcare, Nation's Largest Post-Acute Healthcare Provider, Selects Allscripts Referral Management 3Health News:Kindred Healthcare, Nation's Largest Post-Acute Healthcare Provider, Selects Allscripts Referral Management 4Health News:Kindred Healthcare, Nation's Largest Post-Acute Healthcare Provider, Selects Allscripts Referral Management 5
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014" ... conventional methods developed to prevent and eradicate the prevalence ... These methods are confined to low specificity, safety and ... to look for a better solution. It has been ...
(Date:8/29/2014)... Does your doctor know what you,re smoking?  Chances ... marijuana to the over 112,000 currently registered patients under ... the other roughly 20,300+ active physicians listed with the Colorado ... – even though a poll in February 2014 showed 51% ... tried it. "With marijuana legalization underway, every ...
(Date:8/29/2014)... 2014   Vittamed Corporation , a neurodiagnostics medical device ... that T. (Teo) Forcht Dagi , MD, DmedSc, MPH, ... Directors. " Teo Forcht Dagi is ... innovation and venture capital," said Remis Bistras , President ... his clinical, strategic, and entrepreneurial expertise to our Board." ...
Breaking Medicine Technology:Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2
... Data presented today,at the Annual Congress of ... oral Factor Xa inhibitor DU-176b reduced the incidence,of ... elective unilateral hip replacement surgery. There was a,statistically ... the,observed bleeding rates were low across the groups. ...
... Bypass Surgery for Safety and ... Condition, WASHINGTON, Sept. 1 Patients with both ... will find good news in,new findings announced today from ... Interventions (SCAI). The one-year findings,of the new study indicate ...
Cached Medicine Technology:Daiichi Sankyo Announces Clinical Study Data for Oral Factor Xa Inhibitor DU-176b 2SCAI: CARDia Data Find Diabetic Patients With Complex Heart Disease Can Safely Choose PCI 2SCAI: CARDia Data Find Diabetic Patients With Complex Heart Disease Can Safely Choose PCI 3
The new TOPCON 8800 Series of auto refractors and auto kerato-refractors satisfies the needs of today's demanding eyecare practice !...
The perfect tool to prepare for in-service or licensing exams, for recertification, or for use as a clinical refresher....
... Sun Med TruFlow™ Oxygen flowmeter with a ... warranty covering calibration and manufacturing defects. A ... meet most needs. Also available with all ... power take-off and double unit configurations. Our ...
... flowmeter with a Lexan®inner calibrated flow tube ... manufacturing defects. A wide range of configurations ... available with all popular inlet connections, a ... unit configurations. Our extra large knob coupled ...
Medicine Products: