Navigation Links
Precision with stem cells a step forward for treating MS, other diseases
Date:10/13/2011

Scientists have improved upon their own previous world-best efforts to pluck out just the right stem cells to address the brain problem at the core of multiple sclerosis and a large number of rare, fatal children's diseases.

Details of how scientists isolated and directed stem cells from the human brain to become oligodendrocytes the type of brain cell that makes myelin, a crucial fatty material that coats neurons and allows them to signal effectively were published in Nature Biotechnology by scientists at the University of Rochester Medical Center and the University at Buffalo.

Scientists injected the cells into the brains of mice that were born without the ability to make myelin. Twelve weeks later, the cells had become oligodendrocytes and had coated more than 40 percent of the brain's neurons with myelin a four-fold improvement over the team's previous results published in Cell Stem Cell and Nature Medicine.

"These cells are our best candidates right now for someday helping patients with M.S., or children with fatal hereditary myelin disorders," said Steven Goldman, M.D., Ph.D., the leader of the team and professor and chair of the Department of Neurology at the University of Rochester Medical Center. "These cells migrate more effectively throughout the brain, and they myelinate other cells more quickly and more efficiently than any other cells assessed thus far. Now we finally have a cell type that we think is safe and effective enough to propose for clinical trials."

The first author and co-corresponding author of the paper is Fraser Sim, Ph.D., assistant professor of Pharmacology and Toxicology at the University at Buffalo, who did much of the work while he was a researcher at Rochester.

Sim and Rochester graduate student Crystal McClain ran extensive analyses looking at gene activity in different types of stem cells, leading to the conclusion that stem cells carrying a protein known as
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Precision-tinted lenses offer real migraine relief, reveals new study
2. UCLA uses new hybrid, precision heart procedures to help stop deadly arrhythmias
3. New E-Commerce Website for Spectroscopy Cuvettes and Other Precise Optical Products Launched by NSG Precision Cells
4. USPack Courier Brings Tracking Precision to Medical and Blood Shipments
5. Precision radiation therapy may improve survival rates of some lung cancer patients
6. Medicare Supplement Plan N Information and Rates Now Available Through Precision Senior Marketing
7. Stem cells from cord blood could help repair damaged heart muscle
8. Why many cells are better than one
9. Stem cells, signaling pathways identified in lung repair
10. Bone marrow cells migrate to tumors and can slow their growth
11. Mine-hunting software helping doctors to identify rare cells in human cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Succeed is proud to announce that ... participated in the Every Body Walk! campaign by ... project that encourages workers to be more active outside of ... which concluded at the end of September, was a friendly ... metro areas. Participating companies gave their staff pedometers and ...
(Date:10/20/2014)... October 20, 2014 Unveiled at the Sept. ... Direction Scorecard conservatively estimates member hospital ROI on membership dues ... dues, The Center provides $12.50 in value to member hospitals. ... Value – Member Dues)/Member Dues. , “This is the ... number and we think the methodology is really sound,” said ...
(Date:10/20/2014)... Silver Spring, Maryland, USA (PRWEB) October 20, 2014 ... readers or to track interventions? Here comes a wonderful ... leading mobile app development company helped its ... track Intervention more efficiently. The app is designed for ... iPad, and iPod touch. This app is optimized for ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 Dr. Babatunde ... Fund, welcomes news of a ceasefire agreement that is ... than 200 girls who were kidnapped from the north-eastern ... languished in captivity long enough, and it is high ... communities," stated Dr. Osotimehin. , "We owe it to ...
(Date:10/19/2014)... Recently, Fancyflyingfox.com, an innovative company that provides many ... latest designs of 2014 mother of the bride ... are offered with big discounts, up to 70% off. ... can enjoy this special offer. , Owing to ... become one of the leading brands in the global ...
Breaking Medicine News(10 mins):Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2
... of about 20% of the women who have attained the childbearing ... across the US involving several thousand women. //In the case of ... women belonging to the 16 years to 49 years age group, ... ,The Illinois Chapter of the Sierra Club’s Jack Darin has termed ...
... manufacturer of the experimental AIDS drug GS 9137 Gilead Sciences ... were successful, as lower levels of HIV were noticed in ... The experiment was conducted over a period of 10 days ... were also not seen to be of a serious nature. ...
... Agency for Healthcare Research and Quality has reported that more ... treat burn victims is billed to Medicare or Medicaid, government ... ,According to statistics, the average charge is $59,600 ... the average charge for burn victims with private insurance ...
... :When you doodle for a cause, then it is art ... rub shoulders with the Who’s Who clan, to name a ... their mite for the third National Doodle Day on March ... for the Epilepsy Action and The Neurofibromatosis Association, and is ...
... lives in a competitive world, according to a recent ... educational achievements are concerned, // there is not much ... with a normal birth weight. Earlier research suggested premature ... and academic achievement. ,The researchers studied ...
... following use of the drug aprotinin, marketed as Trasylol, ... drug in heart surgery patients.// The clotting drug is ... cardiac surgery. ,It has now been found ... twice as likely to develop kidney failure and suffer ...
Cached Medicine News:Health News:Art Attack: Doodling For a Cause! 2Health News:Safety Of Heart Drug Questioned 2
(Date:10/20/2014)... , Oct. 20, 2014   Taiho ... Co., Ltd. ( Japan ), announced ... granted Fast Track designation for TAS-102 (nonproprietary names: ... drug under investigation for the treatment of refractory ... has initiated a rolling NDA submission to the ...
(Date:10/20/2014)... and RALEIGH, N.C., Oct. 20, 2014  BioPontis Alliance ... (HNF), both philanthropies, announced today the creation of ... the treatment of the rare disease known as ... announced its alliance model earlier this month. Today,s ... of a collaborative model where researchers and all ...
(Date:10/18/2014)... , Oct. 18, 2014  In a ... Rights Campaign (HRC), the nation,s largest lesbian, gay, ... endorsed the use of Truvada for Pre-Exposure Prophylaxis ... tool used to prevent the spread of a ... the only brand name anti-HIV drug combination currently ...
Breaking Medicine Technology:Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 2Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 3Taiho Oncology, Inc. Receives FDA Fast Track Designation for TAS-102 as a Potential Treatment for Refractory Metastatic Colorectal Cancer 4The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 2The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 3HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3
... announces that a new market research report is ... Global Overview of Herbal/Traditional Products ... for "safer and natural" options remains strong in ... of traditional medicine, consumers are increasing their purchases ...
... Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI), today announced ... preferred Tier 2 formulary status with CVS Caremark ... and Part D Drug Lists), two of the ... million Americans.(1) The U.S. Food and Drug Administration ...
Cached Medicine Technology:Reportlinker Adds A Global Overview of Herbal/Traditional Products 2Pradaxa Gains Preferred Formulary Status with Key Pharmacy Benefit Managers 2Pradaxa Gains Preferred Formulary Status with Key Pharmacy Benefit Managers 3Pradaxa Gains Preferred Formulary Status with Key Pharmacy Benefit Managers 4Pradaxa Gains Preferred Formulary Status with Key Pharmacy Benefit Managers 5
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: