Navigation Links
Precious metal could lead to next generation of cancer treatments
Date:12/8/2008

A precious metal which has never before been used in a clinical setting is being developed as an anti-cancer agent by University of Warwick researchers.

The metal, osmium, is closely related to platinum, which is widely used to treat cancers in the form of the drug cisplatin. Most famously, the cyclist Lance Armstrong was treated with cisplatin for testicular cancer.

Now the researchers, based in the Department of Chemistry, at the University of Warwick, are working closely with Warwick Ventures, the university's technology transfer office, to seek partners to help develop the potential of osmium through more extensive biological tests. The team will be presenting their work on 9 December at the national university technology showcase event, Bioversity.

Professor Peter Sadler, of the Department of Chemistry, explained: "Although cisplatin has been proven to be a very successful treatment; it is not useful for all kinds of cancer. It is also quite a toxic therapy, which can produce side effects and, from a clinical point of view, cells can also become resistant to platinum."

Osmium, with its special chemical properties, offers a new potential solution to an unmet clinical need. It has shown huge promise in treating several different types of cancer cell, including ovarian and colon cancers which have been developed and tested in the laboratory. The metal also has another advantage in that it is a much cheaper alternative to platinum.

Professor Sadler, along with post-graduate researcher Sabine van Rijt, is working to develop new compounds using Osmium, which they hope will lead to the development of drugs which could be used in combination therapies alongside existing drugs such as cisplatin.

"The compounds we have been developing are very promising," says Sabine van Rijt. "We're building a picture of how different compounds might interact with DNA in cancer cells. By making changes to the coating, or ligand, on the metal, we can also affect not just how it interacts, but the rate of interaction.

During this design process we can also make changes which can control the activity of the compound."

She added: "Another advantage is that these compounds are not cross-resistant with platinum. They kill the cancerous cells in a different way, so they could be used alongside platinum in combination therapies."

The team's research is being presented on 9 December at Bioversity 2008, a national university technology showcase event. Bioversity is part of the biotechnology conference, Genesis 2008, organised by The London Biotechnology Network.


'/>"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
44-024-765-23708
University of Warwick
Source:Eurekalert

Related medicine news :

1. Precious Time - Scientists discover how long heart failure patients can expect to live
2. Mothers Day Gives Woman Reason to Celebrate Lifes Most Precious Gift
3. MIPSolutions, Inc. Reduces Expense and Development Time Associated With Precious Metal Extraction
4. Cornell efficiency experts seek to save precious minutes in deploying ambulances
5. Donate Blood - A Simple and Precious Lifegiving Gift
6. Biosensors to probe the metals menace
7. Drug-Coated Stents No Riskier in Long Run Than Bare Metal Ones
8. Heavy metal slips down UK air quality charts
9. Drug-Coated Stents Better Than Bare-Metal Ones in Complex Cases
10. New sensor system improves detection of lead, heavy metals
11. Novel organic metal hybrids that will revolutionize materials science and chemical engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... (PRWEB) , ... September 25, 2017 , ... The Asset ... solution. It is as simple as scanning the bar code of the product ... sent to a secure internet cloud where violations are automatically generated and exception alerts ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... is not an option to senior, upper-level executives speaking at a business luncheon ... "A senior, high-level executive is an asset to be fully realized and activated ...
(Date:9/25/2017)... ... September 25, 2017 , ... Earlypicker is expanding its offerings ... shop for the hottest Korean cosmetics and fashion trends sweeping the nation. The decision ... already well-known for the great offerings that allow Koreans everywhere to look their best ...
(Date:9/25/2017)... ... ... “Renew Refresh Restore Reward”: is a story of struggle and how trouble often ... Deborah Freeman, cofounded the Free Spirit Bible Church and currently serves as the church’s ... invited us to come over before the baby had to go back to her ...
(Date:9/25/2017)... ... September 25, 2017 , ... “Grandpa's Visit”: a tender and relatable ... with the others. “Grandpa's Visit” is the creation of published author, Beverly Brumfield, gifted ... much like the character in her book. She shares, “Mr. Rice is struggling to ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
(Date:9/12/2017)... -- Consumer reviews on the independent review site Consumer Affairs ... for hearing aids, ranking it higher than Miracle Ear ™, ... ... Hearing Aids ... store that provides high performance, state-of-the-art, German-engineered hearing aids directly to ...
Breaking Medicine Technology: