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Pre-treatment with prasugrel -- more risk, no benefit: ACCOAST
Date:9/1/2013

roup at both 7 days (2.6% vs 1.4%, p = 0.006), and 30 days (2.9% vs 1.5%, p = 0.002).

At 7 days, major and life-threatening TIMI bleeding not related to CABG procedures were increased by three-fold and six-fold respectively (1.33% vs 0.45%, p = 0.003; and 0.83% vs 0.15%, p = 0.002).

There was however, no excess of fatal or intracranial hemorrhage with pre-treatment.

ACCOAST is the first randomized study of pre-treatment versus no pre-treatment in NSTE ACS before scheduled catheterization, said Dr. Montalescot. While the study looked specifically at prasugrel, the results, when considered alongside another recent study of pre-treatment with clopidogrel (JAMA. 2013;309(14):1461) are potentially applicable to the global concept of pre-treatment with a P2Y12 inhibitor.


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Source:Eurekalert

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