Navigation Links
Pre-treatment with prasugrel -- more risk, no benefit: ACCOAST
Date:9/1/2013

AMSTERDAM, The Netherlands In patients with non-ST-elevation acute coronary syndrome (NSTE- ACS), pre-treatment with the P2Y12 antagonist prasugrel prior to catheterization, significantly increases the risk of life-threatening bleeding without reducing the risk of major ischemic events, according to the results of the ACCOAST (A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction) trial.

The findings point to a "paradigm shift" away from pre-treatment in such patients which will not only be "hard to believe and destabilizing for many cardiologists, but may also be difficult to implement since the routine use of pre-treatment has been anchored for so long," said the study's lead investigator Gilles Montalescot, from the ACTION study group at the Institut de Cardiologie, Centre Hospitalier Universitaire Piti-Salptriėre, in Paris, France.

Current ESC and ACCF/AHA guidelines recommend that pre-treatment with P2Y12 inhibitors should be added to aspirin as soon as possible before catheterization and maintained over 12 months, unless there are contraindications such as excessive risk of bleeding, explained Dr. Montalescot.

This strategy has been accepted for years based on the results of observational, subgroup and non-randomized analyses performed with the older drug clopidogrel,

But newer P2Y12 receptor antagonists such as prasugrel are more potent and have a faster onset of action, which makes these drugs well-adapted to PCI.

"With the rapid onset of action of the oral and intravenous P2Y12 inhibitors and the modern era of short delays between hospital admission and catheterization, the risk of an ischemic complication before catheterization is extremely low, suggesting that there is no longer a need for pre-treatment in NSTE-ACS patients to prevent ischemic complications while waiting for catheterization," he said. "Moreover, there is also no benefit of pre-treatment on peri-PCI complications. To
'/>"/>

Contact: ESC Press Office
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antioxidants Might Help Cut Pancreatic Cancer Risk, Study Suggests
2. If Colonoscopy Picks Up Cancer Risk, Get Next Screen in 5 Years: Study
3. Weight Control Can Cut Womens Diabetes Risk, Study Shows
4. Your Blood Type May Boost Your Heart Risk, Study Finds
5. People of normal weight with belly fat at highest death risk, Mayo Clinic study
6. Shingles Not Linked to Increased Cancer Risk, Study States
7. Least Aggressive Breast Cancer Still Poses Long-Term Risk, Study Finds
8. Early Menopause May Double Heart Disease Risk, Study Says
9. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
10. Month of Birth Might Help Determine MS Risk, Study Suggests
11. Children of Older Parents With Cancer May Be at Risk, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... 2015 , ... Approximately 2,000 United Methodists are expected to ... children, a thank you to the many creative and generous ways in which ... Methodist initiative to end malaria deaths. , The Columbus Zoo and Aquarium event, ...
(Date:8/28/2015)... ... August 28, 2015 , ... An article published August 19th by ... has gone through to open a pizzeria in Westchester. Mr. LaRocco was aware from ... several months, but the current process, having already gone on for over a year, ...
(Date:8/28/2015)... ... August 28, 2015 , ... For Dallas, the time is nearing for the ... USPI Tenet Health. , The American Heart Association hosts their well-known Heart Walk to ... that together, a difference can be made. Walkers can participate in the cause and ...
(Date:8/28/2015)... ... ... As reported by Medical Daily on August 22 , Cellfina, a ... for two years, the longest of any cellulite reduction system currently on the market. ... effective solution for their cellulite, according to Dr. Robert Weiss, director of the premier ...
(Date:8/28/2015)... ... August 28, 2015 , ... On May 30th, 2015, ... as sponsor of the “Music With A Mission” benefit concert in Mendon, IL. Held ... was to raise money to support music education programs in the underfunded local school ...
Breaking Medicine News(10 mins):Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2
... 16, 2009 A new study published in ... almost twice as high in people with epilepsy compared ... minorities have seven times the odds of depression in ... show that 40 percent of depressed respondents with epilepsy ...
... test capable of confirming or ruling out Alzheimer,s disease ... University of Pennsylvania School of Medicine. By measuring cerebrospinal ... hallmarks amyloid beta42 peptide and tau protein ... impairment would convert to Alzheimer,s disease over time. Researchers ...
... proudly announces that the Peyton Manning Children,s Hospital at ... 6th Annual Talk Walk Run 2009 fundraiser benefiting deaf ... more than 30 years, Hear Indiana has helped children ... members of society," said R. Christopher Miyamoto, pediatric ENT ...
... Will Deliver Educational Training and Professional Certification ... PulseLearning, a leading Ireland-based provider of ... to develop customized eLearning and certification programs ... Casualty Underwriters and the Insurance Institute of ...
... 16 OrbusNeich Medical, Inc. ("Orbus" or the "Company"), ... devices for the treatment of vascular diseases, today announced ... Corporation ("BSC"). The lawsuit, filed in the United ... asserts claims against BSC for patent infringement, breach of ...
... a novel genetic technology that covers up genetic errors, ... Health have developed a successful treatment for dogs with ... and ultimately fatal, muscle disease. , The technology, known ... as molecular "patches." These patches cover up mutant DNA ...
Cached Medicine News:Health News:Depression twice as likely in seizure sufferers 2Health News:Penn Medicine pathologists pioneer biomarker test to diagnose or rule out Alzheimer's disease 2Health News:Penn Medicine pathologists pioneer biomarker test to diagnose or rule out Alzheimer's disease 3Health News:Peyton Manning Children's Hospital at St. Vincent Will Serve As Lead Sponsor of Hear Indiana's 6th Annual Talk Walk Run 2009 2Health News:Ireland's PulseLearning Inks Agreement With Leading U.S. Insurance Industry Association 2Health News:OrbusNeich Files Patent Infringement Lawsuit Against Boston Scientific 2Health News:OrbusNeich Files Patent Infringement Lawsuit Against Boston Scientific 3Health News:Researchers develop DNA 'patch' for canine form of muscular dystrophy 2Health News:Researchers develop DNA 'patch' for canine form of muscular dystrophy 3
(Date:8/28/2015)... -- Research and Markets ( ... "12th Annual Report and Survey of Biopharmaceutical ... offering. The 2015 12th Annual Report ... is the most recent study of biotherapeutic developers ... capacity and production. The report contains the industry,s ...
(Date:8/28/2015)... , Aug. 28, 2015 ... has announced the addition of the "Investigation ... to their offering. Developed by AstraZeneca ... is an important drug for the treatment of ... 2000, quetiapine was listed in the Catalogue of ...
(Date:8/28/2015)... KONG , August 28, 2015 ... in collaboration with one of the leading academics in ... (current world record holder in life extension for model ... insights into biology of aging and age-related diseases, primarily, around ... The work has just been published as "Stability analysis of ...
Breaking Medicine Technology:12th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2China Quetiapine Market Investigation Report 2010-2019 2Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3
... Md., Jan. 31, 2011 Vanda Pharmaceuticals Inc. (Vanda) ... on the development and commercialization of products for central ... a universal shelf registration statement on Form S-3 with ... effective by the SEC, the shelf registration statement will ...
... Technologies, Inc. (the "Company") (Nasdaq: CMED ), ... announced that it will report its unaudited financial results ... before the U.S. market opens on February 18, 2011. ... 2011. The Company,s senior management will ...
Cached Medicine Technology:Vanda Pharmaceuticals Files Shelf Registration Statement 2Vanda Pharmaceuticals Files Shelf Registration Statement 3Vanda Pharmaceuticals Files Shelf Registration Statement 4China Medical Technologies to Announce Results for the Third Fiscal Quarter Ended December 31, 2010 on February 18, 2011 2
The IgA in vitro diagnostic enzyme immunoassay is intended for the qualitative detection of anti-human tTG IgA antibodies in human serum as an aid in the diagnosis of CD....
...
... The FIDIS system and its ... simultaneously and on the same sample, ... dedicated to all types of laboratories ... than today their daily routine, as ...
The PICO50 is used for arterial line sampling....
Medicine Products: