Navigation Links
Pre-surgical stress management boosts immune function, lowers mood disturbance in prostate cancer patients
Date:1/28/2011

HOUSTON - Practicing stress management techniques before prostate cancer surgery may help activate the body's immune response leading to quicker recovery, as well as aid in lowering mood disturbance, according to a new study by researchers at The University of Texas MD Anderson Cancer Center.

The study is published in the February/March edition of the journal Psychosomatic Medicine. It's the first to examine the effects pre-surgery stress management training has on immune outcomes in men with prostate cancer undergoing radical prostatectomy (surgical removal of the prostate). The researchers previously reported that men who received this training before surgery had significantly less mood disturbance and improved quality of life one year later.

Two levels of stress accompany surgery

"Men who face prostatectomy as treatment for prostate cancer often have high stress levels about the procedure and the potential effects on their quality of life," said Lorenzo Cohen, Ph.D., the study's senior author and professor in MD Anderson's Departments of General Oncology and Behavioral Science. "Both the physical and psychological stress of surgery can be harmful to the immune system. Even brief pre-surgery sessions of stress management positively impact on the recovery process, both in terms of psychological and immunological outcomes," he said.

Surgical stress causes a powerful inflammatory response close to the surgery site and throughout the body, raising certain cell-signaling proteins called cytokines that increase inflammation and suppress the immune response. Psychological stress dysregulates cytokine function, reduces the function of natural killer cells and slows wound healing.

While the elevation of inflammatory cytokines may be harmful if sustained, short-term increases before and after surgery may signal an immune response that helps wounds heal and recover.

Participants received different levels of intervention

In the study, 159 men with early-stage prostate cancer who were scheduled for radical prostatectomy were randomized into three groups.

  • Stress management (SM) group participants:
    • Met twice with a psychologist one to two weeks before surgery to discuss concerns and learned some cognitive techniques
    • Learned deep breathing and guided-imagery techniques to help cope with the possible effects of surgery
    • Were led through mental imagery to help prepare for surgery and hospitalization
    • Received a stress management guide that expanded on sessions and audiotapes of techniques to practice on their own
    • Had brief booster sessions with the psychologist on the morning of the surgery
    • Had a brief session 48 hours after surgery to reinforce relaxation and coping strategies
  • Supportive attention (SA) group participants:
    • Met twice with a psychologist one to two weeks before surgery. Sessions were supportive and included a semi-structured psychosocial and medical history in an interview format
    • Were provided empathy and an encouraging environment in which to discuss concerns
    • Had brief booster sessions the morning of surgery
    • Had a brief session 48 hours after surgery to discuss their experiences leading up to the surgery and during their hospital stay
  • Standard Care (SC) received routine medical care and had no meetings with psychologists

Blood samples were collected from each patient about a month before surgery and 48 hours after surgery. Patient mood was measured about a month before surgery, a week before surgery (after the interventions) and the morning of the surgery.

Results show intervention benefits

Two days after surgery, the men in the SM group had:

  • Significantly higher levels of natural killer function and circulating pro-inflammatory cytokines than men in the SA group
  • Higher levels of natural killer function and the cytokine IL-1b than men in the SC group
  • Increased immune system parameters, which decreased or stayed the same for the other two groups

The SM group also had lower mood disturbances before surgery, but this was not found to be associated with immune outcomes.

"This study and evidence from other studies show that psychological intervention before an acute stressor can be beneficial to patients," said Cohen, who is also director of the Integrative Medicine Program. "The implications are that managing stress has biological as well as psychological benefits and might have an effect on aspects of disease."

Further, Cohen says, it suggests that it's important to engage in some type of stress management during stressful periods, especially before surgery.

Next steps

Since the men who took part in this study were mostly white, non-Hispanic, married, and highly educated, researchers say additional studies are needed in more diverse populations, as well as men with advanced disease.

"We're looking at targeting future research to people who might benefit the most, in particular those who are the most distressed and have the lowest level of social support," Cohen said. "This will help provide the most benefit and effective use of health care system's limited resources."


'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Early life stress may predict cardiovascular disease
2. Say “I Love You” From Head to Toe with a Gift That's Healthy and Soothes Away Stress this Valentine's Day
3. Tired of Snow, Sleet, and Stress? Join Deepak Chopra for a Week-Long Meditation Retreat this March in Florida's Warm Sunshine
4. New research shows emotional impact of low sexual desire and associated distress
5. Stress hormone, depression trigger obesity in girls
6. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
7. Family members reduce stress in advanced cancer patients with 14 minute massages
8. Childhood stress such as abuse or emotional neglect can result in structural brain changes
9. Good Parenting Triumphs Over Prenatal Stress
10. Promotional Stress Ball Supplier -- StressBallsUK.com Starts 2010 Strongest Ever
11. New research shows innovative respiratory stress test can quickly detect significant coronary artery disease in a noninvasive setting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pre-surgical stress management boosts immune function, lowers mood disturbance in prostate cancer patients
(Date:10/13/2017)... EDWARDSVILLE, Ill. (PRWEB) , ... ... ... University Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and ... educated healthcare professionals on guideline updates for the primary prevention of cardiovascular ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
(Date:10/4/2017)... Oct. 4, 2017  According to the Centers for Disease Control and ... October . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the ... certain health insurance regulations. ... time to get a flu shot is by the end of October, ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
Breaking Medicine Technology: