Navigation Links
Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
Date:5/30/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 30 (HealthDay News) -- Patients with esophageal cancer who receive chemotherapy and radiation before surgery have better outcomes, Dutch researchers report.

"We think that patients with esophageal cancer have the best chance to survive this cancer when they are treated with preoperative chemo-radiotherapy followed by surgery," said lead researcher Dr. Ate van der Gaast, from the medical oncology department at Erasmus University Hospital in Rotterdam. "By giving preoperative chemo-radiotherapy, more patients are cured than with surgery alone."

In the United States, more than 17,000 people will be diagnosed with esophageal cancer and more than 15,000 will die from it this year, according to the American Cancer Society.

For the study, published in the May 31 issue of the New England Journal of Medicine, the Dutch team randomly assigned nearly 400 people with esophageal cancer either to surgery alone or chemotherapy and radiation before surgery.

The researchers found patients who received chemotherapy before surgery lived an average of four years, while those who went straight to surgery lived an average of two years. More patients in the chemotherapy group had a complete response to treatment and had more of the cancer removed during surgery than those who had surgery alone, the team also noted.

Complications after surgery were similar in both groups, and 4 percent of patients in each group died in the hospital after the procedure, the researchers added.

Dr. Raja Flores, chief of thoracic surgery at Mount Sinai Hospital in New York City, said "these findings were what everyone expected, but not to the degree it came out."

With esophageal cancer, removing the cancer from the area around the tumor is key to treatment. Chemotherapy and radiation is performed before surgery to help contain the cancer so more of it can be removed during the operation, Flores explained.

This approach is becoming standard therapy, he said, "but this study gives the proof positive that that's the way it should go."

Flores said although the treatment adds initial cost, it can save money. "If it leads to more cures, it's going to save money," he said.

Patients need to make sure this approach is discussed with them "so they just don't run straight to surgery," Flores said.

Dr. Harvey Mamon is clinical director of the department of radiation oncology at Brigham and Women's Hospital and Dana Farber Cancer Institute in Boston. He said: "This is an important and well-done study that will influence practice patterns. For all intents and purposes, the standard of care for locally advanced esophageal cancer was already preoperative chemo-radiation followed by surgery."

The significant improvement in the chemo-radiation portion in this trial confirms this current standard of care, he said. "I don't think we're likely to see further trials of surgery alone versus surgery following chemo-radiation."

More information

For more information on esophageal cancer, visit the U.S. National Cancer Institute.

SOURCES: Ate van der Gaast, M.D., Ph.D., medical oncology, Erasmus University Hospital, the Netherlands; Raja Flores, M.D., chief of thoracic surgery, Mount Sinai Hospital, New York City; Harvey Mamon M.D., Ph.D., clinical director, department of radiation oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, associate professor, radiation oncology, Harvard Medical School, Boston; May 31, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ultrasound combined with pre-operative MRI is cost effective in evaluating rotator cuff tears
2. Neuroimaging study may pave way for effective Alzheimers treatments
3. Charging less for more effective treatments could reduce health care costs while improving health
4. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
5. Roseville Radiation Oncology Center (ROC) Redefines Efficiency With Elekta VMAT Radiotherapy Treatments
6. Two Sepsis Treatments Look Equally Effective
7. Heart Stem Cells Move Closer to Human Treatments
8. New Ankle Arthritis Treatments Help Boomers Stay Active
9. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
10. New Alzheimers Prevention Efforts, and Non-Drug Treatments, Featured at 25th Conference of Alzheimers Disease International
11. New Treatments and Good Skin Care Helping Patients Control Acne and Rosacea
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
Breaking Medicine Technology: