Navigation Links
Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
Date:5/30/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 30 (HealthDay News) -- Patients with esophageal cancer who receive chemotherapy and radiation before surgery have better outcomes, Dutch researchers report.

"We think that patients with esophageal cancer have the best chance to survive this cancer when they are treated with preoperative chemo-radiotherapy followed by surgery," said lead researcher Dr. Ate van der Gaast, from the medical oncology department at Erasmus University Hospital in Rotterdam. "By giving preoperative chemo-radiotherapy, more patients are cured than with surgery alone."

In the United States, more than 17,000 people will be diagnosed with esophageal cancer and more than 15,000 will die from it this year, according to the American Cancer Society.

For the study, published in the May 31 issue of the New England Journal of Medicine, the Dutch team randomly assigned nearly 400 people with esophageal cancer either to surgery alone or chemotherapy and radiation before surgery.

The researchers found patients who received chemotherapy before surgery lived an average of four years, while those who went straight to surgery lived an average of two years. More patients in the chemotherapy group had a complete response to treatment and had more of the cancer removed during surgery than those who had surgery alone, the team also noted.

Complications after surgery were similar in both groups, and 4 percent of patients in each group died in the hospital after the procedure, the researchers added.

Dr. Raja Flores, chief of thoracic surgery at Mount Sinai Hospital in New York City, said "these findings were what everyone expected, but not to the degree it came out."

With esophageal cancer, removing the cancer from the area around the tumor is key to treatment. Chemotherapy and radiation is performed before surgery to help contain the cancer so more of it can be removed during the operation, Flores explained.

This approach is becoming standard therapy, he said, "but this study gives the proof positive that that's the way it should go."

Flores said although the treatment adds initial cost, it can save money. "If it leads to more cures, it's going to save money," he said.

Patients need to make sure this approach is discussed with them "so they just don't run straight to surgery," Flores said.

Dr. Harvey Mamon is clinical director of the department of radiation oncology at Brigham and Women's Hospital and Dana Farber Cancer Institute in Boston. He said: "This is an important and well-done study that will influence practice patterns. For all intents and purposes, the standard of care for locally advanced esophageal cancer was already preoperative chemo-radiation followed by surgery."

The significant improvement in the chemo-radiation portion in this trial confirms this current standard of care, he said. "I don't think we're likely to see further trials of surgery alone versus surgery following chemo-radiation."

More information

For more information on esophageal cancer, visit the U.S. National Cancer Institute.

SOURCES: Ate van der Gaast, M.D., Ph.D., medical oncology, Erasmus University Hospital, the Netherlands; Raja Flores, M.D., chief of thoracic surgery, Mount Sinai Hospital, New York City; Harvey Mamon M.D., Ph.D., clinical director, department of radiation oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, associate professor, radiation oncology, Harvard Medical School, Boston; May 31, 2012, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ultrasound combined with pre-operative MRI is cost effective in evaluating rotator cuff tears
2. Neuroimaging study may pave way for effective Alzheimers treatments
3. Charging less for more effective treatments could reduce health care costs while improving health
4. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
5. Roseville Radiation Oncology Center (ROC) Redefines Efficiency With Elekta VMAT Radiotherapy Treatments
6. Two Sepsis Treatments Look Equally Effective
7. Heart Stem Cells Move Closer to Human Treatments
8. New Ankle Arthritis Treatments Help Boomers Stay Active
9. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
10. New Alzheimers Prevention Efforts, and Non-Drug Treatments, Featured at 25th Conference of Alzheimers Disease International
11. New Treatments and Good Skin Care Helping Patients Control Acne and Rosacea
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
Breaking Medicine Technology: