Navigation Links
Pre-emptive pain regimen decreased opioid usage in patients undergoing robotic prostatectomy
Date:6/24/2010

(PHILADELPHIA) Reporting in the journal Urology, researchers at Thomas Jefferson University have found that a pre-emptive multimodal pain regimen that included pregabalin (Lyrica) decreased the use of opioid analgesics in patients undergoing robotic-assisted laparoscopic radical prostatectomy.

Opioid usage, which involves narcotic pain medications, was significantly less in patients who received the multimodal regimen compared to patients who received a standard postoperative analgesic regimen. The mean opioid dose, which was measured in "total morphine equivalent dose," was 75.3 mg for patients who received the standard regimen, versus 49.1 mg for patients who received the multimodal regimen.

"This is the first demonstration of the effectiveness of a pre-emptive pain management protocol using pregabalin in urologic surgery," said Edouard J. Trabulsi, M.D., associate professor of Urology at Jefferson Medical College of Thomas Jefferson University. "We think this study paves the way for new pain management protocols. Though a larger prospective study is necessary to accurately characterize the benefit of reducing opioids, it could have significant implications not only for robotic prostatectomy, but also other laparoscopic procedures and more painful surgeries."

Dr. Trabulsi and colleagues from the Urology and Anesthesiology departments at Jefferson conducted a retrospective study of 60 patients, all undergoing robotic prostatectomy. Thirty of the patients received the multimodal pre-operative treatment and 30 previous patients received only the standard postoperative analgesic regimen.

The pre-operative treatment included pregabalin, acetaminophen and celecoxib given orally, two hours before the procedure, and continued postoperatively in combination with intravenous ketorolac. The standard postoperative analgesic regimen included intravenous ketorolac, without pregabalin or celecoxib. All patients received oxycodone as needed.

Importantly, in addition to the reduced opioid usage, patients who received the pre-operative regimen did not report any additional side effects.

Although laparoscopic surgical techniques typically are associated with a reduction of postoperative pain, patients still require opioid analgesia. The side effects of opioid analgesics often hinder the benefits of laparoscopic surgery. Side effects include nausea, vomiting, a delay in the return of bowel function, ileus, respiratory depression, pruritus, urinary retention and altered sensorium.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. New treatment regimen shown effective against advanced ovarian cancer
2. Combination treatment regimen not effective against advanced melanoma
3. Longer Drug Regimen Still Best Against Breast Cancer
4. Antibiotic regimen effective for reactive arthritis
5. For a Healthier, Cleaner Fitness Regimen - Venture Products Shock Athletic(TM) Mats and Interlocking Flooring
6. Children With Cerebral Palsy Benefitting From New Physical Therapy Regimen
7. Mail-Order May Help People Stick to Med Regimens
8. Heel Pain Usually Relieved With Stretching Regimen
9. Blood stem-cell transplant regimen reverses sickle cell disease in adults
10. Decreased food intake during hospital stays is an independent risk factor for hospital mortality
11. CT and MRI scans associated with shorter hospital stays and decreased costs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... ... changes during the Annual Enrollment Period (AEP) and the Open Enrollment Period (OEP). ... health insurance coverage. Mainly, people are witnessing higher deductibles, rising premiums, and few ...
(Date:1/24/2017)... ... 2017 , ... i2i Population Health, a national leader in population health management ... “Cary’s broad financial background is an excellent fit for i2i,” says Justin Neece, president. ... skills we need to take the company to the next level of growth.” ...
(Date:1/24/2017)... ... 24, 2017 , ... Learn to use popular brainwave and heart rhythm equipment ... Course offered by Dr. Carol Francis at PVNET on Sundays in February and March ... hands-on experiences. , Dr. Carol Francis shows business owners, parents, athletes, students ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s ... its annual Solutions Series of webinars will start January 31 with a session ... number of current health and benefits topics, including employee engagement, pricing transparency, population ...
(Date:1/24/2017)... ... ... Bellus Medical, a leader in medical aesthetics, today announced that Marek Dobke, M.D., ... will provide physician oversight for in-house clinical studies and hands-on device training, among other ... Professor of Surgery at UC San Diego Health and is a board certified plastic ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... India , Jan. 24, 2017 Market Research Future ... Integumentary System Market. The global market for Plastic Surgery & Integumentary ... by the end of the forecasted period. Market Highlights ... Global Plastic Surgery ... market and predicted that the market will reach high growth figures ...
(Date:1/24/2017)... , Jan. 24, 2017 Regeneron Pharmaceuticals, Inc. ... Public today recognized 40 finalists in the Regeneron Science ... and math competition for high school seniors. Finalists were ... of their research projects. The finalists will ... from March 9-15 to undergo a rigorous judging process ...
(Date:1/24/2017)... LONDON , January 24, 2017 Analysis ... End User Liquid Biopsies - our new study reveals ... biopsy market heading? If you are involved in this sector you ... you the potential revenues streams to 2027, assessing data, trends, opportunities ... ...
Breaking Medicine Technology: