Navigation Links
Prasugrel: Indications of an additional benefit for some patients, but also of greater harm
Date:9/15/2011

with ASA monotherapy were not available, which is why the final report cannot draw any conclusions on advantages and disadvantages of prasugrel in patients with STEMI.

No proof, but indication of a benefit

In patients with a "minor" heart attack or unstable angina, i.e. patients with a "non-ST-segment-elevation myocardial infarction" (UA/NSTEMI), IQWiG found indications of a potential advantage of prasugrel plus ASA versus clopidogrel plus ASA. In the TRITON study, patients taking prasugrel suffered fewer (renewed) non-fatal heart attacks or strokes, or required fewer interventions with a balloon catheter for dilatation of the coronary vessels.

IQWiG does not interpret these results as proof, but only as an indication of an advantage of prasugrel, as the study participants only received the medications some time after the occurrence of heart attack symptoms. As prasugrel generally has a more rapid onset of effect, clopidogrel was presumably systematically disadvantaged by the study design. "The rules for a fair comparison were broken here," says Thomas Kaiser, Head of IQWiG's Drug Assessment Department, "We cannot exclude the possibility that the result would have been different if both drugs had been given earlier."

Moreover, regarding the prevention of a stroke, the indication of an additional benefit of prasugrel only applies to certain patients, as such indications were only found in the studies in patients without a known history of vascular disease.

Also indication of harm

At the same time, IQWiG also found indications of greater harm, as major bleeding events occurred more often with prasugrel plus ASA than with clopidogrel plus ASA. This included, for example, bleeding events that required a blood transfusion.

Neoplasia (benign and malignant tumours) were also diagnosed more often in patients treated with prasugrel. However, due to the more common occurrence of bleeding, patie
'/>"/>

Contact: Dr. Anna-Sabine Ernst
info@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Indications of Alzheimers disease may be evident decades before first signs of cognitive impairment
2. Early indications of Parkinsons disease revealed in dream sleep
3. Taking additional selenium will not reduce cancer risk
4. Portable, less costly peritoneal dialysis shows no additional catheter risk factors
5. Wiley-Blackwell announces 102 additional products available through Research4Life
6. Additional cardiac testing vital for patients with anxiety and depression
7. Additional $38M awarded to expand orthopedic trauma care research
8. Virtual colonoscopies help identify additional cancers outside of the colon, study suggests
9. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
10. Project captures Social Security "Stories," Seeks Additional Submissions from Public
11. Vinomis Laboratories Completes Additional Funding Round
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 Zereana Jess-Huff, a 34-year-old mother, ... 2014 on a platform to think outside the bra. She ... her position to raise awareness about women’s other lady parts. ... cancer. You say the color pink and everybody knows what ... a fact that it has not been won when it ...
(Date:10/20/2014)... My Clients Plus ( http://www.MyClientsPlus.com ) ... The new module enables easy administration and routing of ... care. , This application allows users such as Therapists ... a to-do item to a specific client, categorize tasks ... reoccurring reminders for follow-ups. It's designed to enable ...
(Date:10/20/2014)... Diego, CA (PRWEB) October 20, 2014 AttorneyOne.com, ... all the latest information from the FDA on Sit ... on October 10 not to purchase or use Sit and ... Sit and Slim II is promoted as weight loss product ... Sibutramine, removed from the market in 2010 for safety reasons, ...
(Date:10/20/2014)... Rockynol Retirement Community broke ... 14. The $11 million project will include the latest ... kitchen with full-service restaurant style dining. , “We are ... class Assisted Living apartments,” said Kara Hanzie, Rockynol Executive ... quality of care and this investment is proof of ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Based ... are the only imaging assays capable of determining ... single test.  With these three dimensions of high-resolution ... to detect the widest range of disease-causing genetic ... missed by other genomic tools, including today’s advanced ...
Breaking Medicine News(10 mins):Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 2Health News:Ovarian Cancer Survivor Mrs. Maryland Urges Media to Think Outside the Bra 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3
... home-based treatment for hand eczema is just as effective ... to // a new study. Eczema is an inflammatory ... scaling. ,Researchers examined 158 patients with moderate to ... About half the patients followed a home-based program taking ...
... therapy of acupuncture can help those suffering from arthritis ... ,A current multi-location trial included 570 patients ages ... were placed in three groups. One hundred and ninety ... followed a self-help course to manager their condition. The ...
... worldwide. A model based on the findings of a clinical ... severity of acute appendicitis, // according to a new study. ... 89 who underwent an appendectomy within three days of an ... the actual severity of acute appendicitis. The study showed CT, ...
... million people worldwide and is caused by abnormal surges in ... seizures. More than half of those with epilepsy can live ... is under way to determine just how effective surgery is ... epilepsy, the most common form of the disorder. Typically, about ...
... suggests getting active can help elderly patients who have trouble ... between the ages of 67 and 86 in a 90-minute ... exercise followed by 30 minutes of seated social activity and ... in the morning or in the evening, with all participants ...
... pain relief and improves function for people with ... effective complement to Normal care. This study was ... Alternative Medicine (NCCAM) and the National Institute of ... components of the National Institutes of Health.// The ...
Cached Medicine News:Health News:Acupunture relieves pain and improves function in knee Osteoarthritis 2Health News:Acupunture relieves pain and improves function in knee Osteoarthritis 3
(Date:10/19/2014)... , Deutschland, October 19, 2014 ... gefragt. Das Problem dabei ist, dass ... mit der Kompetenz zu teilen. Es ... deshalb freuen wir uns umso mehr, dass es ... ihre Gepflogenheiten bei Kühlketten aufzuschreiben - mit einem ...
(Date:10/17/2014)... , Oct. 17, 2014 With the ... Affairs function has come across several challenges in ... and managing globalization.  The ... is dedicated to providing benchmarking and best practices ... Consortium is a service composed of three stages: ...
(Date:10/17/2014)... Texas , Oct. 17, 2014  Hanger, Inc. ... plans to report its results of operations for the ... 2014 after the market closes.  A conference call to ... a.m., ET, on Friday, November 7, 2014. Those wishing ... available until Friday, November 14, 2014 by dialing 1-855-859-2056 ...
Breaking Medicine Technology:Vergleichsbericht zu Pharma-Kühlketten und CRT 2Early Key Findings from the Medical Affairs Consortium Research 2
... Calif., Dec. 9, 2010 Ambry Genetics, a global ... sciences industries, announced today that it has officially launched ... Genetics has been an early adapter of Illumina sequencing ... Certified Service Provider. (Logo:   http://photos.prnewswire.com/prnh/20090428/LA06744LOGO ...
... 9, 2010 A new study shows that ... hormonal therapy tamoxifen in patients with hormone-receptor positive/human ... cancer who have been previously treated with an ... tamoxifen alone. These results were presented today at ...
Cached Medicine Technology:Ambry Genetics Launches Illumina HiSeq 2000 Next Generation Sequencing Services 2Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 2Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 3Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 4Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 5Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 6Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 7Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 8Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 9Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 10Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients 11
... An integrated approach to quality patient care., ... an innovative approach to anesthesia delivery. As ... combines enhanced ventilation features, electronically controlled gas ... and information management to create a truly ...
A non-adhering hydrogel sheet dressing for use on all partial and full thickness wounds (excluding 3rd degree burns.) Hydrogel sheet contains 96% water and 4% insoluble cross-linked polyethylene oxid...
... External Vacuum Therapy System restores sexual function ... Non-invasive and low cost vacuum therapy, coupled ... outcome", makes it the ideal therapy for ... System causes penile rigidity that can be ...
... D.O.R.C. Harmony Special Peristaltic phacoemulsification system features ... including individual programmability and remote control for ... a front panel with color coded function ... for ease of use and viewing. Under ...
Medicine Products: