Navigation Links
Prasugrel: Indications of an additional benefit for some patients, but also of greater harm
Date:9/15/2011

pproved in Germany solely in combination with ASA for patients with acute coronary syndrome (ACS), i.e. with acute stenosis of the coronary vessels, who are to undergo surgery in the form of a PCI to dilate their vessels. These patients have either unstable angina pectoris or have suffered an acute heart attack.

In contrast to prasugrel, clopidogrel is not approved in patients who experienced a "severe" heart attack (i.e. an "ST-segment-elevation myocardial infarction", STEMI) and therefore undergo a PCI. However, in practice, clopidogrel is still also commonly used in these patients, but it has not yet been sufficiently investigated in studies whether they benefit from this. Following the requirements of the contracting agency, the Federal Joint Committee (G-BA), the benefit assessment of prasugrel was to be conducted within the approval status valid in Germany. Accordingly, in patients with STEMI, IQWiG only compared prasugrel plus ASA combination therapy versus ASA monotherapy, but not versus clopidogrel plus ASA combination therapy.

Two studies included in the assessment

IQWiG included 2 studies in the assessment: in one long-term study (TRITON), patients were followed between 6 and 15 months, and in one short-term study (JUMBO) up to 35 days. TRITON and JUMBO were randomized controlled trials, and both compared the combination therapies prasugrel plus ASA versus clopidogrel plus ASA.

In both studies, large groups of participants were treated differently than envisaged in the German approval conditions for prasugrel and clopidogrel. IQWiG could therefore use the results only for the subgroups of participants receiving approval-compliant treatment. In this context, IQWiG's conclusions are primarily based on the TRITON study, as, with several thousand patients, considerably more patients received approval-compliant treatment than in the JUMBO study (less than 200 patients).

Studies comparing prasugrel plus ASA
'/>"/>

Contact: Dr. Anna-Sabine Ernst
info@iqwig.de
49-022-135-6850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Indications of Alzheimers disease may be evident decades before first signs of cognitive impairment
2. Early indications of Parkinsons disease revealed in dream sleep
3. Taking additional selenium will not reduce cancer risk
4. Portable, less costly peritoneal dialysis shows no additional catheter risk factors
5. Wiley-Blackwell announces 102 additional products available through Research4Life
6. Additional cardiac testing vital for patients with anxiety and depression
7. Additional $38M awarded to expand orthopedic trauma care research
8. Virtual colonoscopies help identify additional cancers outside of the colon, study suggests
9. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
10. Project captures Social Security "Stories," Seeks Additional Submissions from Public
11. Vinomis Laboratories Completes Additional Funding Round
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... announced today that will analyze how changes in ... contribute to healthy aging. , Conducted by ... a $10 million unrestricted gift from the Amway ... identify lifestyle and environmental factors that may help ... age. WELL will be designed, conducted, and analyzed ...
(Date:9/17/2014)... In its latest blog post, Best Drug ... family close by during a stay in rehab can make ... successful, is highlighting a member of the therapeutic care team ... addicts across the country and around the world: dogs. ... blood pressure, heart rate, and stress levels in recovering addicts,” ...
(Date:9/17/2014)... Bioluminescence, nanoparticles, gene manipulation these sound like ... in fact, they are components of an exciting ... In preclinical animal models of metastatic prostate cancer, ... VCU Institute of Molecular Medicine and Johns Hopkins ... molecular imaging approach that could revolutionize doctors, ability ...
(Date:9/17/2014)... In Pretrial Order #139 (Scheduling of ... conferences would be beneficial in this [MDL].” Accordingly, the ... the end of December,” the order further provides, “the ... conferences. , “The plain import of this order ... much to be discussed as these cases progress toward ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, ... household chemicals known as phthalates might increase a child,s ... in a new study. Children had nearly an ... 5 and 11 if their mothers were exposed during ... the researchers found. The two phthalates were butylbenzyl phthalate ...
Breaking Medicine News(10 mins):Health News:First-ever research study examines impacts of diet and lifestyle on healthy aging 2Health News:Latest Best Drug Rehabilitation Blog Post Highlights How Dogs are Helping Addicts Recover 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 3Health News:Transvaginal Mesh Lawsuit News: New Order in C.R. Bard MDL Sets Schedule of Conferences for September to December, the Rottenstein Law Group LLP Reports 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 3Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 4
... appears higher in non-Hispanic white adolescent girls and young ... in lower socioeconomic areas, according to a report posted ... issue of Archives of Dermatology , one of ... form of skin cancer and represents a substantial cause ...
... , MONDAY, March 21 (HealthDay News) -- A woman,s ... the risk of respiratory problems in her children, according to ... mother,s use of birth control pills may increase the risk ... inconclusive, said the authors of the new study. The ...
... (Mar. 21, 2011) -- A new study published by ... of California, Davis, foresees improvements in patient outcomes after ... technology. A control tower-style telemedicine hub to manage electronic ... boost the likelihood that critically injured victims will get ...
... less likely to refer short girls than short boys ... for their short stature, according to a new study ... medical conditions causing their short stature may go undiagnosed, ... treatment. Researchers from The Children,s Hospital of Philadelphia ...
... during pregnancy is common and is associated with significant ... Despite warnings from the Surgeon General to limit alcohol ... by the National Birth Defects Prevention Study(1) found that ... during their pregnancy, with one-fourth of the women surveyed ...
... Ellin Holohan HealthDay Reporter , SUNDAY, March 20 ... risk of developing diabetes and heart disease, according to a ... four other inflammatory conditions. The study, which looked at ... found higher rates of diabetes and heart illness among asthmatics ...
Cached Medicine News:Health News:Melanoma diagnosis in women associated with higher socioeconomic status 2Health News:Moms' Use of 'the Pill' Won't Raise Kids' Asthma Risk: Study 2Health News:Health information technology 'control tower' could improve earthquake response 2Health News:Medically underserved girls receive less frequent evaluation for short stature 2Health News:Medically underserved girls receive less frequent evaluation for short stature 3Health News:Adolescent offspring of women who drank alcohol during first trimester 2Health News:Study Ties Asthma to Higher Odds for Diabetes, Heart Disease 2Health News:Study Ties Asthma to Higher Odds for Diabetes, Heart Disease 3Health News:Study Ties Asthma to Higher Odds for Diabetes, Heart Disease 4
(Date:9/17/2014)... Sept. 17, 2014 Women everywhere know how ... not only uncomfortable, they,re often also embarrassing and have ... Feminine Health Support ( http://ph-defense.com ) is a new, ... an all-natural, homeopathic product. Odor, discharge, ... of vaginal infection. In many cases, the cause of ...
(Date:9/17/2014)... 2014  Aratana Therapeutics, Inc. (NASDAQ: ... licensing, developing and commercializing innovative biopharmaceutical products for ... public offering of 4,500,000 shares of its common stock at ... share. Aratana has granted the underwriters a 30-day ... shares of its common stock. Jefferies ...
(Date:9/17/2014)... , Sept. 17, 2014  Neuraltus Pharmaceuticals, Inc. announced ... 2 clinical program of NP001 for the treatment of ... disease) are being highlighted today in an oral presentation ... Group , being held in Bloomington, Minnesota ... hoc  analysis, administration of a high dose of NP001 ...
Breaking Medicine Technology:New Product from Vireo Systems: pH-D Feminine Health Support 2Aratana Therapeutics, Inc. Announces Pricing of Public Offering 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 3
... (ASH) Annual Meeting ... Publication Number: 840, ... thromboses (blood clots),and transfusion requirements in patients with a rare ... have,been expected to have less severe disease, according to data ...
... Mich., Dec. 10 CSG/SportsCoatings and,the National Wrestling ... the most proactive and proven method of controlling,bacteria, ... Nationally renowned for its Sports Antimicrobial System (R) ... on all types of,athletic surfaces and fabrics for ...
Cached Medicine Technology:PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 2PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 3PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 4PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 5PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 6PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 7PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity 8National Wrestling Coaches Association Teams Up With CSG/SportsCoatings(TM) 2
18" Penrose drains...
Provides reliable suction for surgical cases with larger amounts of drainage....
Reliavac® 400cc kits with flat drain, Y-connector tubing...
Reliavac 100cc evacuators offer a more constant suction profile than silicone evacuators. 100cc capacity is easy for patient to carry. Bottom emptying port reduces chance of contamination....
Medicine Products: