Navigation Links
Powerful free radical causes lung damage from oxygen therapy
Date:10/5/2010

AUGUSTA, Ga. The most toxic free radical appears responsible for much of the lung damage that can result from oxygen therapy in the critically ill or injured, Medical College of Georgia researchers report.

Within just a few days, ventilators and oxygen chambers used to significantly increase oxygen levels can also dramatically increase levels of peroxynitrite, an oxidant powerful enough to break down DNA and cause proteins to malfunction, said Dr. Yunchao Su, pharmacologist in the MCG Schools of Medicine and Graduate Studies.

Oxygen toxicity is the most severe side effect of oxygen therapy in newborns and adults. The lungs take the brunt of the damage, which can include inflammation, hemorrhaging and swelling that may result in death or chronic lung problems, said Su, corresponding author of the study published in the Journal of Biological Chemistry.

"We knew it was bad but we did not know why," Su said. The good news is they may also have a solution.

Researchers found that within five days, mice placed in small oxygen chambers that mimic oxygen levels given in intensive care have dramatically elevated levels of peroxynitrite in their lungs. Free radicals, such as peroxynitrite, result from oxygen use and are safe at low levels. While it's a given that oxygen therapy produces free radicals, the significant increase in peroxynitrite was not known.

The trouble begins when high oxygen levels prompt endothelial cells that line blood vessels and tiny airs sacs in the lung to make more nitric oxide, the precursor of peroxynitrite. At high levels, nitric oxide, most often a helpful compound, combines with other free radicals produced by excess oxygen use to form the powerful peroxynitrite. "As oxygen levels increase, nitric oxide levels increase and so peroxynitrite levels do as well," Su said.

But he appears to have identified a break point in the destructive cycle. Su found that in the face of high oxygen levels, the enzyme tha
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Breaching the blood-brain barrier to create powerful new tools for fighting cancer
2. doeLegal and Zapproved Sign Alliance to Add Legal Hold Pro to Suite of Powerful Online Legal Solutions
3. New Book Reveals the Powerful and Undermining Impact of Stress on Good Decision Making and What Leaders Can Do About It
4. Powerful People Often Too Optimistic About Task Time
5. Adapting to clogged airways makes common pathogen resist powerful drugs
6. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
7. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
8. Lumenis Announced Today it is Sponsoring the Endometriosis Foundation of America's Symposium 'Advancing the Art and Science of Endometriosis: Stem Cells to Radical Excision Surgery'
9. Henry Ford Health System goes radical: Creating the hospital of the future
10. Cigarette smoke causes harmful changes in the lungs even at the lowest levels
11. Scientists closer to finding what causes the birth of a fat cell
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Powerful free radical causes lung damage from oxygen therapy
(Date:7/31/2015)... ... ... Like nearly every other form of surgery, it shouldn't come as a ... less intrusive and painful. Leading these advances in the United States has been ... as the only doctor in the United States who is qualified to practice, and ...
(Date:7/31/2015)... ... ... The Heart Fit Clinic has increased a patient's fitness level 60 percent ... beats versus 100 beats, this is a big deal," says Diamond Fernandes, director of ... patients with heart disease," he adds. People with angina are able to do a ...
(Date:7/31/2015)... ... July 31, 2015 , ... Burnaby sports physiotherapy clinic, Absolute ... understanding and treatment of ankle sprains. A common sports injury, ankle sprains are ... dangerous if the condition augments and causes more disruption. Absolute PhysioCare’s blog discusses ...
(Date:7/31/2015)... ... July 31, 2015 , ... Awarded to only the Top 10 ... announce that they are the latest recipients of the Center of Clinical Excellence ... of the worldwide leaders in the science of hair transplant. , Parsa Mohebi Hair ...
(Date:7/31/2015)... ... ... is a reputable source of authentic USA vs. Australia tickets at Ford Field ... Team in conjunction with their Victory Tour to celebrate winning the 2015 Women's World Cup ... was awarded the Golden Ball as the best player of the 2015 Women's World Cup. ...
Breaking Medicine News(10 mins):Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2Health News:Absolute PhysioCare & Sports Rehab Promotes Understanding & Treatment of Ankle Sprains 2Health News:Prestigious Medical Award Given To Parsa Mohebi Hair Restoration for Excellence in Hair Transplantation 2Health News:Cheap USA vs. Australia Tickets at Ford Field in Detroit, MI: Ticket Down Slashes Ticket Prices for Australia vs. USWNT International Friendly Match at Ford Field 2
... Health Care for All Depends on Adequate RN StaffingSILVER SPRING, ... American Nurses, AFL-CIO, pledged to redouble their efforts to secure ... Schakowsky (D-IL) -- that would make federal RN staffing ratios ... Nurses Week, I can think of no better gift for ...
... at American College of Obstetricians and Gynecologists, 57th Annual ... Surgical, Inc., a medical device company that has developed ... technology, released results from a preclinical study demonstrating that ... improved fascia incision healing in an in vivo model ...
... 2009 In a letter to the Editor of the ... by Elsevier, S. Lefebvre and J.S. Weese from the University ... MRSA and C.difficile could be passed between pet ... C. difficile may have been transferred to the ...
... blood clots are often recommended to stop these medications ... However, interruption of these medications can place patients at ... by Shai Friedland at the VA Palo Alto hospital ... without interrupting anticoagulation. Their study will be published on ...
... Elsevier, the world,s leading publisher of scientific, technical, ... Walsh, MSc, FACP, FRCP (Edin) on receiving the ... Project on Death in America (PDIA) Palliative Medicine ... AAHPM 2009 Annual Assembly on March 26. , ...
... Work, Money and the EconomySeven out of 10 ... 7 Economic pressures are having an increasing ... to a new survey by the American Psychological ... reporting significant stress related to work, money, housing ...
Cached Medicine News:Health News:UAN Hails Reintroduction of Federal RN Staffing Ratio Bill and Vows to Work for Passage 2Health News:PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery 2Health News:PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery 3Health News:PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery 4Health News:PEAK Surgical Announces Positive Fascia Incision Healing Results From Preclinical Study of PEAK PlasmaBlade(TM) for Gynecologic Surgery 5Health News:Transmission of MRSA and Clostridium difficile through dogs 2Health News:Author Declan Walsh honored with National Leadership Award in Palliative Medicine 2Health News:APA Poll Finds Economic Stress Taking a Toll on Men 2Health News:APA Poll Finds Economic Stress Taking a Toll on Men 3
(Date:7/30/2015)... International Inc. (NYSE: MTD ) today announced second ... , Sales in local currency increased 3% ... sales decreased 4% as currency reduced sales growth by ... diluted share as reported (EPS) were $2.73, compared with ... , an increase of 9% over the prior-year ...
(Date:7/30/2015)... SAN DIEGO , July 30, 2015 /PRNewswire/ ... a medical device company and manufacturer of the ... it has entered into non-exclusive Development Agreements with ... generation Tandem insulin pumps with the Dexcom G5 ... "Integrating Tandem,s next generation pump platform with ...
(Date:7/30/2015)... , July 30, 2015  OncoGenex Pharmaceuticals, Inc. ... report its second quarter 2015 financial results on Thursday, ... call and live webcast at 4:30 p.m. Eastern Time ... programs and a general corporate update. ... Relations page of the OncoGenex website at www.oncogenex.com ...
Breaking Medicine Technology:Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3
... AXA Research Fund closed out its first year of existence. ... 13 million to various European research institutions.The purpose of the ... risks in the world by supporting cutting edge scientific research. ... million over five years, making it a major initiative in ...
... N.J., March 23 Each year in the United States ... myeloma. These new cases account for 10 percent of ... For several types of leukemia, the survival rate has ... James M. Golubieski, president of Foundation Venture Capital Group, LLC, ...
Cached Medicine Technology:First Year Results of the AXA Research Fund: Over Euro 13 Million Allocated for Research in 2008 2First Year Results of the AXA Research Fund: Over Euro 13 Million Allocated for Research in 2008 3Foundation Venture Capital Group Invests in UMDNJ Company Working to Improve Leukemia Treatments 2
... The ISYSTEM-ABD ("I-cubed") is an ... featuring an analog oscilloscope (static deflection) ... and resolution than low cost video ... hyaloid, syneresis, inflammatory cells, as well ...
ISYSTEM-ABDv2™A/B Scan unit. True Geometry With Stepped Zoom, Pan, Freeze Frame, Post Image Processing....
... is a combination A-scan and B-scan system, ... A-scan incorporates a high frequency, low noise ... scan capture immediately upon application of the ... where the axial length of both eyes ...
The P45 Ultrasonic Workstation provides the highest ultrasound resolution for imaging....
Medicine Products: