Navigation Links
Pourquié Lab uncovers mechanism contributing to appropriate formation of the spine
Date:6/18/2008

The Stowers Institute's Pourqui Lab has shed light on the mechanism causing animals to develop the appropriate number of vertebrae.

Vertebrae are formed from their embryonic precursors, called somites. The number of somites is consistent within a species, but varies significantly across species. By comparing the developing embryos of zebrafish, chicken, mice, and corn snakes, the team established an understanding of how an organism regulates the number of somites formed.

The findings were published today in Nature's advance online publication.

"We set out to understand why snakes form hundreds of vertebrae, while mice form about 50, and humans form just 33," said Cline Gomez, Ph.D., formerly a Postdoctoral Research Associate at the Stowers Institute and lead author on the paper. "We found that the control of both body elongation and vertebrae precursor size accounts for the different numbers of vertebrae in each of these species the smaller the vertebrae precursors are along the body length, the more vertebrae are formed."

The presomitic mesoderm is the middle layer of the three cell layers that form an early embryo. It increases in size as the somites form and then gradually shrinks until it is exhausted, terminating the process when the appropriate number of somites have been formed.

"In examining these diverse species, we discovered that the same process ended somite formation in each," said Olivier Pourqui, Ph.D., Investigator and senior author on the publication. "What influenced the number of somites in each species was the rate of somite formation. In snake embryos, somites form much more quickly than in the other species. As a result, there are more somites, but they are smaller."

Understanding the mechanism of vertebral column development in animals offers insight into how the spine forms in humans. A better understanding of the process may aid in the prevention or treatment of disorders like congenital scoliosis.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related medicine news :

1. New Research Uncovers how to Build and Maintain an Effective Competitive Intelligence Group
2. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
3. First-of-Its-Kind National Survey Uncovers Obstacles to Comprehensive Healthcare for People With Schizophrenia
4. First-of-Its-Kind National Online Survey Uncovers Obstacles to Comprehensive Healthcare for People With Schizophrenia
5. Study uncovers cause of flu epidemics
6. New Research Uncovers How to Build and Maintain an Effective Competitive Intelligence Group
7. Porn Nation Uncovers the Sexualization of America
8. Vaseline(R) Cocoa Butter Campaign Uncovers Skins Ability to Speak Volumes
9. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
10. UCSD study reveals the regulatory mechanism of key enzyme
11. Ancient mechanism for coping with stresses also gives cancer a boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
Breaking Medicine Technology: