Navigation Links
Pourquié Lab uncovers mechanism contributing to appropriate formation of the spine
Date:6/18/2008

The Stowers Institute's Pourqui Lab has shed light on the mechanism causing animals to develop the appropriate number of vertebrae.

Vertebrae are formed from their embryonic precursors, called somites. The number of somites is consistent within a species, but varies significantly across species. By comparing the developing embryos of zebrafish, chicken, mice, and corn snakes, the team established an understanding of how an organism regulates the number of somites formed.

The findings were published today in Nature's advance online publication.

"We set out to understand why snakes form hundreds of vertebrae, while mice form about 50, and humans form just 33," said Cline Gomez, Ph.D., formerly a Postdoctoral Research Associate at the Stowers Institute and lead author on the paper. "We found that the control of both body elongation and vertebrae precursor size accounts for the different numbers of vertebrae in each of these species the smaller the vertebrae precursors are along the body length, the more vertebrae are formed."

The presomitic mesoderm is the middle layer of the three cell layers that form an early embryo. It increases in size as the somites form and then gradually shrinks until it is exhausted, terminating the process when the appropriate number of somites have been formed.

"In examining these diverse species, we discovered that the same process ended somite formation in each," said Olivier Pourqui, Ph.D., Investigator and senior author on the publication. "What influenced the number of somites in each species was the rate of somite formation. In snake embryos, somites form much more quickly than in the other species. As a result, there are more somites, but they are smaller."

Understanding the mechanism of vertebral column development in animals offers insight into how the spine forms in humans. A better understanding of the process may aid in the prevention or treatment of disorders like congenital scoliosis.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related medicine news :

1. New Research Uncovers how to Build and Maintain an Effective Competitive Intelligence Group
2. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
3. First-of-Its-Kind National Survey Uncovers Obstacles to Comprehensive Healthcare for People With Schizophrenia
4. First-of-Its-Kind National Online Survey Uncovers Obstacles to Comprehensive Healthcare for People With Schizophrenia
5. Study uncovers cause of flu epidemics
6. New Research Uncovers How to Build and Maintain an Effective Competitive Intelligence Group
7. Porn Nation Uncovers the Sexualization of America
8. Vaseline(R) Cocoa Butter Campaign Uncovers Skins Ability to Speak Volumes
9. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
10. UCSD study reveals the regulatory mechanism of key enzyme
11. Ancient mechanism for coping with stresses also gives cancer a boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... ... 12, 2017 , ... Health Literacy Innovations (HLI), creator of ... and the Cancer Patient Education Network (CPEN), an independent professional organization that shares ... strategic alliance. , As CPEN’s strategic partner, HLI will help support CPEN ...
(Date:10/12/2017)... ... 12, 2017 , ... Farm Forward joins Bon ... leading institutions in announcing the launch of the Leadership Circle , a ... are raised for food. , Founding members of the Leadership Circle also include ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
Breaking Medicine Technology: