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Potential 'universal' blood test for cancer discovered
Date:7/28/2014

Researchers from the University of Bradford, UK, have devised a simple blood test that can be used to diagnose whether people have cancer or not.

The test will enable doctors to rule out cancer in patients presenting with certain symptoms, saving time and preventing costly and unnecessary invasive procedures such as colonoscopies and biopsies being carried out. Alternatively, it could be a useful aid for investigating patients who are suspected of having a cancer that is currently hard to diagnose.

Early results have shown the method gives a high degree of accuracy diagnosing cancer and pre-cancerous conditions from the blood of patients with melanoma, colon cancer and lung cancer. The research is published online in the FASEB Journal, the US Journal of the Federation of American Societies for Experimental Biology.

The Lymphocyte Genome Sensitivity (LGS) test looks at white blood cells and measures the damage caused to their DNA when subjected to different intensities of ultraviolet light (UVA), which is known to damage DNA. The results of the empirical study show a clear distinction between the damage to the white blood cells from patients with cancer, with pre-cancerous conditions and from healthy patients.

Professor Diana Anderson, from the University's School of Life Sciences led the research. She said: "White blood cells are part of the body's natural defence system. We know that they are under stress when they are fighting cancer or other diseases, so I wondered whether anything measureable could be seen if we put them under further stress with UVA light. We found that people with cancer have DNA which is more easily damaged by ultraviolet light than other people, so the test shows the sensitivity to damage of all the DNA the genome in a cell."

The study looked at blood samples taken from 208 individuals. Ninety-four healthy individuals were recruited from staff and students at the University of B
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Contact: Jenny Watkinson
j.watkinson2@bradford.ac.uk
44-127-423-6030
University of Bradford
Source:Eurekalert  

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Potential 'universal' blood test for cancer discovered
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