Navigation Links
Potential treatments from cryptic genes
Date:6/1/2008

Big pharma gave up on soil bacteria as a source of antibiotics too soon, according to research published in the June issue of Microbiology. Scientists have been mining microbial genomes for new natural products that may have applications in the treatment of MRSA and cancer and have made some exciting discoveries.

"Over the last eight years we have been looking for new natural products in the DNA sequence of the antibiotic-producing bacterium Streptomyces coelicolor," said Professor Gregory Challis from the University of Warwick. "In the last 15 years it became accepted that no new natural products remained to be discovered from these bacteria. Our work shows this widely-held view to be incorrect."

In 1928 Alexander Fleming discovered penicillin, which was subsequently developed into a medicine by Florey and Chain in the 1940s. The antibiotic was hailed as a 'miracle cure' and a golden age of drug discovery followed. However, frequent rediscovery of known natural products and technical challenges forced pharmaceutical companies to retreat and stop looking for new molecules.

Currently the complete genetic sequences of more than 580 microbes are known. It is possible to identify pathways that produce new compounds by looking at the DNA sequences and many gene clusters likely to encode natural products have been analysed. 'Genome mining' has become a dynamic and rapidly advancing field.

Professor Challis and his colleagues have discovered the products of two cryptic gene clusters. One of the clusters was found to produce several compounds that inhibit the proliferation of certain bacteria. Three of these compounds were new ones, named isogermicidin A, B and C. "This discovery was quite unexpected," said Professor Challis. "Our research provides important new methodology for the discovery of new natural products with applications in medicine, such as combating MRSA infections."

The other product they discovered is called
'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Most caregivers of young children lack basic knowledge of potentially toxic household products
2. Conseco Declines Proposal from Steel Partners II, L.P.; Proposal Would Reduce Consecos Financial Flexibility and Potentially Disadvantage Other Shareholders
3. UNC study firms up promise of potential new cervical cancer screening tool
4. A potential route for human tumor gene therapy
5. High Growth Potential for Carotid Stent and Thoracic Aortic Stent Graft Markets
6. Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome
7. Estimated 3.2 million Burmese potentially affected by cyclone
8. Most Baby Boomers are Financially Unprepared for a Potential Disability
9. New report: Arthritis is a potential barrier to physical activity for adults with diabetes
10. Improving anxiety treatment through the help of brain imaging: A potential future treatment strategy
11. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... Pioneer Millworks reclaimed USA wood will be on ... Show, an annual, premier sustainable building event in Tokyo, ... manufacturers of the latest building products, services and technology. ... manufactured by Pioneer Millworks from their Oregon and New ... hotels, retailers, and corporate offices. Nichibi Global , ...
(Date:2/28/2015)... India Network Foundation, a US ... programs for visitors coming to the United States for ... to the United States are suffering from one or ... These diseases are so common among the elderly population ... conditions. There were 66.8 million cases of diabetes in ...
(Date:2/28/2015)... Boardman, Ohio (PRWEB) February 28, 2015 ... Bold? Motivational? Supportive? Strategic? , There are all ... unique strengths. To raise awareness of the advantages ... analysis firm PeopleKeys is launching a new product ... help clients better understand the connection between personality ...
(Date:2/28/2015)... February 28, 2015 The noted Toronto ... Facial Surgery was recently featured in the January/February 2015 ... magazine, Dr. David Ellis was featured in an article ... various cosmetic enhancements that Kim Cattrall has possibly undergone ... “Her forehead is smooth without horizontal lines or frown ...
(Date:2/28/2015)... February 28, 2015 “ Powermod ” was ... which takes a look at the latest and coolest technology ... reporter for NewsWatch and a technology expert, conducted the review ... of charging solutions. , Getting stuck with a low battery ... a problem that people face on a daily basis. Even ...
Breaking Medicine News(10 mins):Health News:US Reclaimed Wood from Pioneer Millworks to be Featured at Architecture & Construction Materials Show in Tokyo. 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 2Health News:India Network Announces Pre-existing Condition Health Insurance Coverage for Diabetic Visitors of All Ages Traveling to the United States 3Health News:PeopleKeys Launches The Leadership Report 2Health News:PeopleKeys Launches The Leadership Report 3Health News:Dr. David Ellis Featured In Elevate Magazine 2Health News:Solutions to Keep Phones Charged were Featured on NewsWatch Television on January 29, 2015 2
... Dimes, along with its partners, are giving experts in the ... each other and to work together to bring the nation,s ... a healthy start. U.S. Surgeon General Regina Benjamin ... symposium will was a forum to share lessons learned from ...
... (BRONX, NY) Researchers at Albert Einstein College of ... , the University Hospital for Einstein, have found a biomarker ... patient,s tumor will be life threatening. The biomarker is considered ... immediately following diagnosis. This discovery could become a component of ...
... 13 new regions of the genome associated with the timing ... involved in reproductive lifespan and will provide insights into conditions ... Menopause is a major hormonal change that ... The timing of menopause can have a huge impact on ...
... inspired to write a book by his conversations with his ... and the impact the disease has on their lives. In ... patient and specialist, how both sides deal with cancer, their ... patients. Jonathan Waxman tackles the issue of cancer ...
... HealthDay Reporter , SUNDAY, Jan. 22 (HealthDay ... they believe are linked with breast cancer that may ... All three newly identified areas "contain interesting genes that ... said researcher Douglas Easton, a professor of genetic epidemiology ...
... patients treated for breast cancer is seriously compromised and ... menopause, a decrease in physical activity and weight gain, ... Comprehensive Cancer Center. , The study, published in the ... found that the mental issues faced by younger breast ...
Cached Medicine News:Health News:March of Dimes launches Prematurity Prevention Network 2Health News:March of Dimes launches Prematurity Prevention Network 3Health News:Molecular fingerprint discovered that may improve outcomes for head and neck cancer patients 2Health News:Genes and timing of menopause 2Health News:True stories from the cancer ward 2Health News:New Genetic Clues to Breast Cancer? 2Health News:New Genetic Clues to Breast Cancer? 3Health News:Quality of life for younger breast cancer patients more adversely affected than older women 2Health News:Quality of life for younger breast cancer patients more adversely affected than older women 3
(Date:2/27/2015)... HILL, N.C. , Feb. 27, 2015 ... over the past decade but one thing hasn,t changed: ... MSLs to build relationships with Key Opinion Leaders. ... recognized as the most valuable type of interaction, field ... limits on their KOL interactions. This is just one ...
(Date:2/27/2015)... 27, 2015  Following a bipartisan vote in ... H.R. 284, the Medicare DMEPOS Competitive Bidding Improvement ... Homecare (AAHomecare) released a statement praising the Committee,s ... the legislation. "Today,s mark-up of the ... and Means Committee is a critical step forward ...
(Date:2/27/2015)... , Feb. 27, 2015 An aggressive campaign ... cut the rate of infection with a dangerous drug-resistant ... Clostridium difficile, or C.diff, is a bacterium ... inflammation of the colon. A recent article in the ... difficile Infection in the United States ...
Breaking Medicine Technology:Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2Bidding Fix Takes Major Step Forward After Bipartisan Vote of House Ways and Means Committee 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 3
... Inc., a,biopharmaceutical company engaged in the discovery and ... diseases, announced today,that Genentech, a collaborator, has moved ... antibody, into a phase 1 clinical trial,that has ... the,safety and tolerability of both single and multiple ...
... Therapeutics, Inc. today,announced completion of a Phase ... kappa opioid agonist, CR845, under development for ... drug candidate was safe and,well-tolerated after intravenous ... expected to be associated with clinical analgesic ...
Cached Medicine Technology:Tolerx Announces Achievement of Milestones upon anti-CD4 Antibody Program Advancement and Initiation of Phase 1 Clinical Trial 2Tolerx Announces Achievement of Milestones upon anti-CD4 Antibody Program Advancement and Initiation of Phase 1 Clinical Trial 3Cara Therapeutics Announces Successful Completion of Phase I Clinical Trial of Novel Analgesic, CR845 2
... The Series I Instrument program offers state-of-the-art ... profile, while maintaining strength and durability. Low ... in tight joint spaces. Series I instruments ... tip style, size and angle required for ...
... The Series I Instrument program offers ... low profile, while maintaining strength and durability. ... pathology in tight joint spaces. Series I ... cutting tip style, size and angle required ...
... The Series I Instrument program offers ... low profile, while maintaining strength and durability. ... pathology in tight joint spaces. Series I ... cutting tip style, size and angle required ...
... WideBiter Punch series facilitates fast and effective ... smooth, anatomically shaped meniscal rim. The flat, ... to access even the tightest joint spaces. ... Inc., 20 years of engineering experience in ...
Medicine Products: