Navigation Links
Potential treatments from cryptic genes
Date:6/1/2008

Big pharma gave up on soil bacteria as a source of antibiotics too soon, according to research published in the June issue of Microbiology. Scientists have been mining microbial genomes for new natural products that may have applications in the treatment of MRSA and cancer and have made some exciting discoveries.

"Over the last eight years we have been looking for new natural products in the DNA sequence of the antibiotic-producing bacterium Streptomyces coelicolor," said Professor Gregory Challis from the University of Warwick. "In the last 15 years it became accepted that no new natural products remained to be discovered from these bacteria. Our work shows this widely-held view to be incorrect."

In 1928 Alexander Fleming discovered penicillin, which was subsequently developed into a medicine by Florey and Chain in the 1940s. The antibiotic was hailed as a 'miracle cure' and a golden age of drug discovery followed. However, frequent rediscovery of known natural products and technical challenges forced pharmaceutical companies to retreat and stop looking for new molecules.

Currently the complete genetic sequences of more than 580 microbes are known. It is possible to identify pathways that produce new compounds by looking at the DNA sequences and many gene clusters likely to encode natural products have been analysed. 'Genome mining' has become a dynamic and rapidly advancing field.

Professor Challis and his colleagues have discovered the products of two cryptic gene clusters. One of the clusters was found to produce several compounds that inhibit the proliferation of certain bacteria. Three of these compounds were new ones, named isogermicidin A, B and C. "This discovery was quite unexpected," said Professor Challis. "Our research provides important new methodology for the discovery of new natural products with applications in medicine, such as combating MRSA infections."

The other product they discovered is called
'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Most caregivers of young children lack basic knowledge of potentially toxic household products
2. Conseco Declines Proposal from Steel Partners II, L.P.; Proposal Would Reduce Consecos Financial Flexibility and Potentially Disadvantage Other Shareholders
3. UNC study firms up promise of potential new cervical cancer screening tool
4. A potential route for human tumor gene therapy
5. High Growth Potential for Carotid Stent and Thoracic Aortic Stent Graft Markets
6. Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome
7. Estimated 3.2 million Burmese potentially affected by cyclone
8. Most Baby Boomers are Financially Unprepared for a Potential Disability
9. New report: Arthritis is a potential barrier to physical activity for adults with diabetes
10. Improving anxiety treatment through the help of brain imaging: A potential future treatment strategy
11. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... (PRWEB) May 02, 2015 ZoomCare, the ... has submitted plans to offer its new healthcare insurance ... The ZOOM+ Personal Health Insurance System is the nation’s ... to enhance human performance. ZOOM+ Personal Health Insurance was ... delivery system that are subject to review and regulation ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 Pioneer Millworks, ... share the latest in their reclaimed wood products at ... the Jacob Javits Center in NYC this May. Their ... will bring much anticipated texture and color to North ... an explosion of texture and color in the design ...
(Date:5/1/2015)... Mesa, CA (PRWEB) May 01, 2015 ... at the Cerner Southeast Regional User Group (RUG) Conference ... The Cerner Southeast Regional User Group Conference provides a ... to vendors who support all aspects of electronic medical ... use of Cerner software applications. , In addition to ...
(Date:5/1/2015)... CA (PRWEB) May 01, 2015 The ... genetic makeup and the interplay of genes with one ... with developments can be daunting. , LabRoots, the premier ... clinical diagnostics professionals, will soon host its annual conference ... At BioConference Live Genetics and Genomics 2015 , ...
(Date:5/1/2015)... Digital technology and Wi-Fi-enabled medical equipment may ... appointments, a preliminary study has shown. ... low-risk pregnant women, will be presented as a poster ... Associates at the 2015 American Congress of Obstetricians and ... The digital technology used was developed by Babyscripts™ ...
Breaking Medicine News(10 mins):Health News:ZoomCare Applies to be on Oregon Exchange 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 3Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 3Health News:Recent Advances in Genetics and Genomics: A BioConference Live 2015 Virtual Event 2Health News:Recent Advances in Genetics and Genomics: A BioConference Live 2015 Virtual Event 3Health News:Mobile Technology May Be Effective in Monitoring Pregnant Women Between Office Visits, Study Shows 2Health News:Mobile Technology May Be Effective in Monitoring Pregnant Women Between Office Visits, Study Shows 3
... comes to estimating calorie counts, Americans aren,t really on ... Journal of Consumer Research , this may be ... food. "The sequence in which items are considered ... Alexander Chernev (Northwestern University). "The focus on sequential estimation ...
... By Kathleen Doheny HealthDay Reporter ... new studies may help breast cancer patients and ... reconstruction after mastectomy. One study finds that ... after having had a mastectomy with immediate reconstruction ...
... ultimate goal to discover a drug that one day treats ... on pinpointing the mechanisms in the brain that respond to ... in the UH College of Pharmacy, received a three-year, $450,000 ... In the end, his team hopes their research will help ...
... of prostate tumors, promotes the growth of a different type ... online on September 20 in the Journal of Experimental ... and colleagues find that TAL1, a protein abundantly expressed in ... (T-ALL), drives expression of NKX3.1. Eliminating NKX3.1 halted the ...
... might not benefit from some of the tuberculosis vaccines currently ... are designed to activate a specific molecule that is an ... people. But a recent Ohio State University study suggests that ... the face of TB infection. The animal research suggests ...
... of Utah determined that the 2009 pandemic influenza A ... children than the seasonal flu. The most common ... of the study, the most extensive evaluation of neurological ... the September issue of Annals of Neurology , ...
Cached Medicine News:Health News:Low-calorie cheesecake? Why we have trouble estimating calories 2Health News:Breast Reconstruction After Mastectomy: Now or Later? 2Health News:Breast Reconstruction After Mastectomy: Now or Later? 3Health News:Drug to treat alcoholism goal of UH professor's research 2Health News:Elderly might not benefit from TB vaccines in development 2Health News:Elderly might not benefit from TB vaccines in development 3Health News:Higher incidence of seizures seen in children with H1N1 virus compared to seasonal flu 2
(Date:5/1/2015)... , May 1, 2015 Semler Scientific, Inc. ... company that develops, manufactures and markets products that assist ... today reported financial results for the first quarter ended ... quarter of 2015, Semler reported continued progress with year ... quarter revenue growth of 14%," said Doug Murphy-Chutorian ...
(Date:5/1/2015)...  AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ), a specialty ... innovative therapies for the treatment of acute and breakthrough ... chief financial officer  will be participating in three upcoming ... Mizuho Third Annual Healthcare Corporate Access Day ... New York Bank ...
(Date:5/1/2015)... May 1, 2015  Shares of Aerie Pharmaceuticals, Inc. ... value yesterday following the results of the Phase 3 ... Despite the trial failing to meet its end points, ... may come from future studies. An analyst ... current pipeline, financial review, analyst summary, valuation, and recommendation ...
Breaking Medicine Technology:Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5AcelRx Pharmaceuticals to Participate at Upcoming Investor Conferences in May 2All is Not Lost for Aerie Pharmaceuticals - VLM Research Issued by BrokerBank Securities, Inc. 2
... , ALISO VIEJO, Calif., Nov. 17 OCTANe hosted ... companies to discuss promising technology and emerging trends for the ... Medical Device & Investor Forum. , For the first ... transactions in Orange County history discussed the details of the ...
... , NEW YORK, Nov. 17 Engineer/pilot/attorney Jon Roberts, ... They include technology that thwarts piracy in movie theatres, ... to enhance airport security and even an electronic matchmaker ... they have, indeed, found their match. Now, as ...
Cached Medicine Technology:OCTANe's Medical Device & Investor Forum Highlights Key Trends, Investment Opportunities 2When Viruses (Including H1N1) and Bacteria are as Close as your Fingertips; VirWall's New Innovation Can Disarm Killer Keyboards 2
Integra Epilepsy grid electrodes are thin and flexible for easier placement and to conform to the curvature of the cortical surface. Lead tunneling is done using a 14-gauge tunneling needle (ET-2)....
...
... Electrodes feature exceptional quality and design to ... seizure recording technology. Neurosurgeons worldwide consider these ... flexible available. Our electrodes come in many ... 4-contact strips to 64-contact grids. Their bodies ...
... designed for laboratories looking for time and ... system operation in terms of easy reagent ... and on-board stability., ,URISYS 2400 is ... walk-away capability for medium to high volume ...
Medicine Products: