Navigation Links
Potential treatment for a specific kind of pancreatic cancer
Date:9/16/2013

Australian researchers have identified a potentially treatable subtype of pancreatic cancer, which accounts for about 2% of new cases. This subtype expresses high levels of the HER2 gene. HER2-amplified breast and gastric cancers are currently treated with Herceptin.

Pancreatic cancer is the fourth leading cause of cause of cancer death in Western societies, with a 5-year survival rate of less than 5%. It is a molecularly diverse disease, meaning that each tumour will respond only to specific treatments that target its unique molecular make-up.

A new study, published in Genome Medicine, used a combination of modern genetics and traditional pathology to estimate the prevalence of HER2-amplified pancreatic cancer. Pancreatic surgeon Professor Andrew Biankin, from Sydney's Garvan Institute of Medical Research and the Wolfson Wohl Cancer Research Centre at the University of Glasgow, worked with pathologist Dr Angela Chou and bioinformatician Dr Mark Cowley from Garvan, as well as cancer genomics specialist Dr Nicola Waddell from the Queensland Centre for Medical Genomics at the University of Queensland.

Using data sourced from the Australian Pancreatic Cancer Genome Initiative1 (APGI), the team identified a patient with high-level HER2 amplification. Using whole genome DNA sequencing of the tumour, Dr Nicola Waddell pinpointed the specific region of the genome that contains HER2.

Dr Angela Chou then performed detailed histopathological characterisation of HER2 protein in tissue samples taken in the past from 469 pancreatic cancer patients. This produced a set of standardised laboratory testing guidelines for testing HER2 in pancreatic cancer, and showed the frequency of HER2 amplified pancreatic cancer of 2.1%.

Dr Chou also found that - like HER2-amplified breast cancer patients - the cancers of those with HER2-amplification in the pancreas tended to spread to the brain and lung, rather than the norm, which is the liver.

Dr Mark Cowley analysed all the data generated by the project and compared it to other sequences from many cancer types produced by the International Cancer Genome Consortium and The Cancer Genome Atlas project. "HER2 amplification was prevalent at just over 2% frequency in 11 different cancers," he observed.

"We make the case that if HER2 is such a strong molecular feature of several cancers, then perhaps recruiting patients to clinical trials on the basis of the molecular features rather than the anatomical region of their cancer could have a significant impact on patient outcomes, and still make economic sense for pharmaceutical companies. Such "Basket" trials, as they are sometimes called, may advance treatment options for those with less common cancer types."

In Australia, 2,000 people are diagnosed with pancreatic cancer each year, and so 40 are likely to have the HER2 amplified form.

While Herceptin is available through the Pharmaceutical Benefits Scheme for treating breast and gastric cancer, it is not available for treating HER2-amplified pancreatic cancer as no clinical trial has yet been conducted to determine the drug's efficacy in that case.

The Garvan Institute in collaboration with the Australasian Gastro-Intestinal Trials Group, is recruiting pancreatic cancer patients through the APGI for a pilot clinical trial, known as 'IMPaCT'2, to test personalised medicine strategies.

Potential patients will be screened for specific genetic characteristics, including high levels of HER2, based on their biological material sequenced as part of the APGI study. Once these characteristics are confirmed, patients will be randomised to receive standard therapy or a personalised therapy based on their unique genetic make-up.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-243-407-1326
Garvan Institute of Medical Research
Source:Eurekalert

Related medicine news :

1. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
2. Potential Drug AMG Services LDL Reduction, Declared "New Hope" by Home And Recreation Lifestyle Magazine
3. The Holistic Sanctuary Recognizes International Overdose Awareness Day by Citing CIR Report About Potential Fraud at Conventional Drug Rehab Centers
4. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
5. Paducah, KY Gum Disease Treatment can Now Potentially Reduce Risk of Low Birth Weight by Removing Gum Disease in Expecting Mothers with Dr. Kelvin White
6. Researchers Discover a Potential Cause of Autism
7. Yardley, PA Gum Disease Treatment Can Potentially Prevent Tooth Loss Using Laser Gum Surgery with Dr. Edward Marcus of Floral Vale Periodontics & Implants
8. Headquarters Relocation to Reno, Nevada Brings 41 Potential Jobs
9. Is There a Dark Side to High Potency Calcium? Source Naturals MBP Bone Renew Helps Consumers Avoid Potential Risks
10. Statman, Harris & Eyrich, LLC Announces Investigation into Potential Fraudulent Practices of Drug and Treatment Centers
11. The CAI, NIH & NCI Partnership: The NCI Invention Portfolio for High Commercial Potential Based on CAI’s Proprietary and Rigorous Business Market and Scientific Criteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... Brenton Engineering , powered by Pro ... wrapped products at WestPack 2015, February 9-11, in Anaheim, California. This new solution ... or fully-automatic case packing with a small footprint, rugged, highly flexible, and cost-effective ...
(Date:2/8/2016)... ... February 08, 2016 , ... The ... has selected the latest beneficiary of their ongoing community enrichment program. The current ... in area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html . , ...
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying ... , According to Perry A~, author of “Calcium Bentonite Clay” the health benefits of ... in balancing and detoxifying the body. , A former motivational speaker, Perry A~ has ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth cohort with ... time to make a change in public health,” states Carole Baggerly, Director of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Guruji Mahendra Kumar Trivedi is offering ... 2016 in honor of his birthday on February 10th. During this time, people ... is known by over 250,000 people from over 40 different countries as an “ordinary ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... underwritten secondary offering of 11,027,558 shares of its common ... of Blackstone and Goldman Sachs.  The shares are being ... $96.45 per share. The selling stockholders will receive all ... nor any of its directors, officers or other stockholders ...
(Date:2/5/2016)... -- Henry Schein, Inc. (NASDAQ: HSIC ), the world,s largest ... dental, animal health and medical practitioners, announced today that ... majority ownership interest in Dental Cremer S.A., a distributor ... . --> ... dental distribution business of Cremer S.A. With 2015 sales ...
(Date:2/5/2016)... , February 4, 2016 France ... Spain , UK, and Israel ). It ... 1, 2, and 3 GD, segmented by age and sex in these ... epidemiologists. The EpiCast Report is in-depth, high quality, transparent and market-driven, providing ... France , Germany , Italy ...
Breaking Medicine Technology: