Navigation Links
Potential treatment and prevention of Parkinson's disease
Date:8/1/2014

This news release is available in German.

Parkinson's disease affects neurons in the Substantia nigra brain region their mitochondrial activity ceases and the cells die. Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics show that supplying D-lactate or glycolate, two products of the gene DJ-1, can stop and even counteract this process: Adding the substances to cultured HeLa cells and to cells of the nematode C. elegans restored the activity of mitochondria and prevented the degeneration of neurons. They also showed that the two substances rescued the toxic effects of the weed killer Paraquat. Cells that had been treated with this herbicide, which is known to cause a Parkinson's like harm of mitochondria, recovered after the addition of the two substances. Both glycolic and D-lactic acids occur naturally in unripe fruits and certain kinds of yoghurt. Products with an enriched concentration of these substances could thus be a therapeutic route for a treatment of Parkinson's or for even preventing the onset of the disease.

Teymuras Kurzchalia and Tony Hyman both have labs at the Max Planck Institute of Molecular Cell Biology and Genetics with rather different research programs but both happened to stumble upon the gene DJ-1 and joined forces. This gene, originally thought of as an oncogene, has been linked to Parkinson's disease since 2003. Recent studies showed that DJ-1 belongs to a novel glyxolase family. The major function of these genes is assumed to detoxify aggressive aldehyde by-products from mitochondrial metabolism. The Dresden research team now showed that the products of DJ-1, D-lactate and glycolate, are actually required to maintain the high mitochondrial potential and thus can prevent the degeneration of neurons implicated in Parkinson's disease.

Their experiments proved that both substances are lifesavers for neurons: Adding them to affected cells, in other words cells treated with the environmental poison Paraquat or with a down-regulated DJ-1, decreased the toxic effect of the herbicide, restored the activity of the mitochondria and thus ensured the survival of the neurons.

We do not yet understand how exactly D-lactate and glycolate achieve this curative and preventive effect, but the next step will be to investigate the molecular mechanism underlying this process", say Hyman and Kurzchalia. In addition to further molecular investigation, they also have more concrete plans for the future: As Kurzchalia says "we can develop a yoghurt enriched with D-lactate: It could serve as a protection against Parkinson's and is actually very tasty at the same time!" This is why the researchers have filed a patent for their finding.

Many diseases are associated with a decline in mitochondrial activity, not only Parkinson's. Thus, the researchers believe that the DJ1-products could have a general role in protecting cells from decline.


'/>"/>

Contact: Dr. Teymuras Kurzchalia
kurzchalia@mpi-cbg.de
49-351-210-2567
Max-Planck-Gesellschaft
Source:Eurekalert  

Related medicine news :

1. Study identifies potential treatment for lethal childhood leukemia
2. McMaster researchers find potential for new uses of old drug
3. Army researcher develops potential vaccine carrier
4. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
5. New study of NIH funding allocations suggests potential efficiency gains
6. A closer look at PARP-1 reveals potential new drug targets
7. Hybrid vaccine demonstrates potential to prevent breast cancer recurrence
8. VCU Massey Cancer Center sees potential in novel leukemia treatment
9. Misuse of over-the-counter pain medication is potential health threat
10. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
11. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potential treatment and prevention of Parkinson's disease
(Date:1/23/2017)... ARLINGTON, VA (PRWEB) , ... ... ... Seafood Nutrition Partnership (SNP) has launched online education programs and resources at ... health and nutritional benefits of a seafood-rich diet. These resources have been ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Some Infallible Characteristics of Christ”: a ... Characteristics of Christ” is the creation of published author, Rev. Dr. Robert W. Thomas, ... thirteen years, a preacher for over nineteen, a pastor for over fifteen years. He ...
(Date:1/22/2017)... (PRWEB) , ... January 22, 2017 , ... Phytocéane invites ... isolated from the rest of the world with ZANZIBAR MILKY CREAM. Inspired by the ... key ingredients like Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, ...
(Date:1/22/2017)... ... 22, 2017 , ... "Photo Cloud allows FCPX users to add favorited photos ... complete ease," said Christina Austin - CEO of Pixel Film Studios. , To ... timeline. Presets include scenes with one, three, four or five focus points. There ...
(Date:1/21/2017)... ... January 21, 2017 , ... Caronlab Australia, an Australian company known for ... Show in Hilton Head, SC, where it benefited from outstanding meetings with major retail ... beauty and wellness products. At this trade show, the company had the chance to ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Jan 20, 2017 Research and Markets ... Market Trends, Opportunities, and Future" report to their offering. ... This research service ... trends, and technologies, and provides a snapshot of the key participants ... and forecasts are provided from 2016 to 2020. The market is ...
(Date:1/19/2017)... , Jan. 19, 2017 ... Summary GlobalData,s new report, "Germany Cataract Surgery Devices ... the Germany Cataract Surgery Devices market. The report provides ... and average prices (USD) within market segements - Phacoemulsification ... also provides company shares and distribution shares data for ...
(Date:1/19/2017)... Call and Webcast to Follow Vanda Pharmaceuticals Inc. (Vanda) ... for the fourth quarter of 2016 on Wednesday, February 15, 2017, ... ... ET on Wednesday, February 15, 2017, during which management will discuss ... corporate activities. To participate in the conference call, please dial 1-888-771-4371 ...
Breaking Medicine Technology: