Navigation Links
Potential preventative therapy for Type 1 diabetes
Date:4/29/2009

Scientists believe they may have found a preventative therapy for Type 1 diabetes, by making the body's killer immune cells tolerate the insulin-producing cells they would normally attack and destroy, prior to disease onset.

Type 1 diabetes is an autoimmune condition, where the body attacks its own insulin producing cells. It is very serious, with a sudden and dramatic onset, usually in youth. People with Type 1 diabetes must maintain an insulin-monitoring and insulin-injecting regimen for the rest of their lives.

PhD student Eliana Mario and Dr Shane Grey, from the Garvan Institute of Medical Research in Sydney, have demonstrated how a particular molecule may be used in future as a preventative therapy. Their findings are published online in the international journal Diabetes.

The body's immune cells, or white blood cells, include B cells and T cells. B cells make antibodies and present 'antigens' to T cells, allowing them to recognise, and kill, invaders.

In previously published studies about Type 1 diabetes, Mario and Grey showed that groups of B cells migrate to the pancreas and pancreatic lymph nodes, presenting specific insulin antigen to T cells. In other words, B cells go to the disease site and tell T cells to kill the cells that produce insulin.

"Taking that work further, our current study looks at different ways of subduing B cells, and how that affects development of the disease," said Grey.

Working with mice that spontaneously develop Type 1 diabetes, Eliana Mario found that if she blocked BAFF (a hormone that controls survival of B cells) prior to onset, none of the mice developed diabetes.

"This is a remarkable finding, as other B cell depletion methods tested elsewhere have just delayed or reduced disease incidence," said Eliana.

When B cells were depleted, the regulators of the immune system (a subclass of T cells known as T regulatory cells) rose in numbers.

By removing B cells from the picture for a while, it appears you allow T regulatory cells to function as they should, subduing killer T cells and somehow making them tolerant of the insulin producing cells.

The Juvenile Diabetes Research Foundation supported this research. Garvan's Diabetes Vaccine Development Centre (DVDC), the mandate of which is to develop a vaccine for Type 1 Diabetes, is funding further research with the compound.

The molecule used by Grey and colleagues to inhibit BAFF is known as BCMA, and is already being used in clinical trials for other autoimmune diseases, such as Sjogren's Syndrome and Lupus.


'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-043-407-1326
Research Australia
Source:Eurekalert

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. UCLA study identifies designer estrogen as potential MS drug
3. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
4. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
5. Potential new approach to treat cognitive impairments in schizophrenia
6. Nosespray vaccine using aloe vera has exciting potential, researcher says
7. Network approach identifies potential breast cancer susceptibility gene
8. Liver fibrosis will be treated by a potential target
9. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
10. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
11. China Holdings, Inc. Announces 2nd Biomass Renewable Energy Project (Power Capacity: 50 MW); Total Potential: 100 MW in Biomass Energy Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... ... patient advocates stress that the patient context (age, illness and life choices) should ... to mitigate their occurrence. In addition, all too often, studies regarding ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... chain management (SCM) and spend management, today announced that Keppel Corporation has selected ... simplify expense tracking. , “We are excited to announce the partnership between ...
(Date:2/21/2017)... , ... February 22, 2017 , ... Author Michèle Wolff ... valuable for every household and family to know all about it for optimal health. ... with the release of “ Detox, Digestive and Wellness Solutions ” (published by Balboa ...
(Date:2/21/2017)... IL (PRWEB) , ... February 21, 2017 , ... ... connectivity solutions, has introduced five new hospital-grade power extension cords that meet the ... Services (CMS) of the 2012 edition of the National Fire Protection Association (NFPA) ...
(Date:2/21/2017)... ... 21, 2017 , ... Doctors on Liens has announced the addition of ... , to its growing network of doctors in Central and Northern California. Dr. Mendonca ... such as whiplash, back pain, neck pain, hip and knee pain, and headaches. ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Research and Markets has ... by Drug Molecule (Biologic, Small Molecule Drugs), By Route of ... Blockers) Outlook 2022" report to their offering. ... The global psoriasis ... 2016-2022 This report provides a detailed analysis of ...
(Date:2/22/2017)... -- Based on its recent analysis of the sleep ... Inc. with the 2017 European New Product Innovation ... intelligently addresses the root causes of sleep apnea ... proven continuous transmucosal electrical stimulation therapy. Because of ... the most accessible anti-snoring products available in the ...
(Date:2/22/2017)... HAYWARD, Calif. , Feb. 22, 2017  Applied Silver, ... Sue Barnes to the company,s advisory board. Ms. Barnes ... total, joining business, advertising, engineering, legal, and healthcare experts ... , John Goodrich , J. Tress Ritter , ... RN, BSN, CIC, FAPIC brings more than three decades of ...
Breaking Medicine Technology: