Navigation Links
Potential new 'twist' in breast cancer detection
Date:12/4/2009

Working with mice, scientists at Johns Hopkins publishing in the December issue of Neoplasia have shown that a protein made by a gene called "Twist" may be the proverbial red flag that can accurately distinguish stem cells that drive aggressive, metastatic breast cancer from other breast cancer cells.

Building on recent work suggesting that it is a relatively rare subgroup of stem cells in breast tumors that drives breast cancer, scientists have surmised that this subgroup of cells must have some very distinctive qualities and characteristics.

In experiments designed to identify those special qualities, the Hopkins team focused on the gene "Twist" (or TWIST1) named for its winding shape because of its known role as the producer of a so-called transcription factor, or protein that switches on or off other genes. Twist is an oncogene, one of many genes we are born with that have the potential to turn normal cells into malignant ones.

"Our experiments show that Twist is a driving force among a lot of other players in causing some forms of breast cancer," says Venu Raman, Ph.D., associate professor of radiology and oncology, Johns Hopkins University School of Medicine. "The protein it makes is one of a growing collection of markers that, when present, flag a tumor cell as a breast cancer stem cell."

Previous stem cell research identified a Twist-promoted process known as epithelial-to-mesenchymal transition, or EMT, as an important marker denoting the special subgroup of breast cancer stem cells. EMT essentially gets cells to detach from a primary tumor and metastasize. The new Hopkins research shows that the presence of Twist, along with changes in two other biomarkers CD 24 and CD44 even without EMT, announces the presence of this critical sub-group of stem cells.

"The conventional thinking is that the EMT is crucial for recognizing the breast cancer cell as stem cells, and the potential for metastasis, b
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Rcadia COR Analyzer(R) System Demonstrates Potential in Emergency Department Triage of Chest Pain Patients at Low to Moderate Risk of Coronary Artery Disease
2. Researchers identify proteins in lung cancer cells that may provide potential drug targets
3. Candidate Potential Report Reduces Risk of Bad Hires
4. Pivotal study for PSD502 -- the first potential treatment for premature ejaculation
5. Heavy Snoring Linked To Potentially Life-Threatening Conditions
6. U.S. Healthcare Efficiency Index(TM) Launches Primary Data Collection to Measure Current State of Electronic Adoption and Potential Cost Savings
7. New activity found for a potential anti-cancer agent
8. Surgery potentially best option for severe migraine headaches
9. Canadian scientists link fat hormone to death from potentially deadly blood infection
10. CEL-SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL-2000 Has Potential to Slow Damage Caused by Rheumatoid Arthritis
11. Mice regain ability to extend telomeres suggesting potential for dyskeratosis congenita therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... (PRWEB) June 02, 2015 The ... Miriam Wirski as a 2015-2016 inductee into its ... with this prestigious distinction for leadership in business. NAPW ... women, boasting more than 700,000 members and over 200 ... with this prestigious honor,” said NAPW President Star Jones. ...
(Date:6/1/2015)... June 02, 2015 The National ... Cade as a 2015-2016 inductee into its VIP ... this prestigious distinction for leadership in business. NAPW is ... boasting more than 700,000 members and over 200 operating ... this important honor,” said NAPW President Star Jones. “Her ...
(Date:6/1/2015)... 2015 Carson Energy also announced they ... IRA transactions. AdvantaIRA Trust, LLC is the country’s largest ... to fund positions using IRA’s does 2 things:, 1. ... project, even if there current cash position will not ... source for Carson and their investors to be able ...
(Date:6/1/2015)... The Delta Dental Foundation is currently seeking applications ... Ohio and Indiana for its Brighter Futures Community Grants ... been set. , Across the tri-state area, the program ... focus on children’s oral health and $100,000 in grants ... Each grant request will be considered and carefully reviewed ...
(Date:6/1/2015)... June 01, 2015 EBSCO Health ... today introduced DynaMed Plus™ , a cross-platform evidence-based ... professionals. It provides clinicians with the ideal blend of ... care paths. , DynaMed Plus is a significant ... includes the most frequently updated evidence-based content. DynaMed Plus ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Miriam Wirski, Holistic Life Coach, Into its VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Linda Cade, Senior Product Manager at Sage, Into its VIP Professional Woman of the Year Circle 2Health News:Carson Energy Brings Oil Wells To IRAs 2Health News:Brighter Futures Community Grants Program Seeks to Help Fund Local Oral Health Programs 2Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 2Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 3Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 4
... Stereotaxis, Inc. (Nasdaq: STXS ) today reported strong revenue ... expenses and a significant reduction in the net loss for ... 30, 2009. Revenue for the recent third quarter totaled ... the 2008 third quarter. During the quarter, the Company ...
... LLC a wholly owned subsidiary of Superior Global Solutions, Inc. ... announced that it has completed its acquisition of the assets ... of medical documentation and workflow management software based in Marietta, ... top healthcare clients across the US. Under the terms of ...
... ... Texas, is launching a powerful new website complete with the latest tools of the internet. Author ... using his website as an educational resource for visitors seeking treatment for an array of skin ... (Vocus) November 5, 2009 -- ...
... ... developer of intellectual property rights management systems. , ... London, UK (PRWEB) November 5, 2009 -- Rights management ... investor YFM Group., , , , ,Also following their existing investment was the Creative Capital ...
... The ... a reality as Thailand continues to see an increase in medical tourism. With an annual ... of Thailand (TAT) and the Department of Export Promotion (DEP) expects to see two million ... ...
... ... Global Solutions, Inc. a leader in healthcare outsourcing, today announced that it has completed ... provider of medical documentation and workflow management software based in Marietta, Georgia. , ... Plano, TX (PRWEB) November ...
Cached Medicine News:Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 2Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 3Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 4Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 5Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 6Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 7Health News:Stereotaxis Reports 26% Third Quarter 2009 Revenue Growth 8Health News:Superior Global Solutions, Inc. Acquires HTI Technologies, Inc. 2Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 2Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 3Health News:Rights Tracker Completes Fundraising 2Health News:Thailand's Medical Tourism is Booming - Thailand on its Way to Become Asia's Medical Hub 2Health News:Thailand's Medical Tourism is Booming - Thailand on its Way to Become Asia's Medical Hub 3Health News:Superior Global Solutions, Inc. Acquires HTI Technologies, Inc. 2Health News:Superior Global Solutions, Inc. Acquires HTI Technologies, Inc. 3
(Date:6/1/2015)... 2015  Elusys Therapeutics, Inc. (Elusys) today announced ... accepted for filing and review its Biologics License ... and prevention of inhalational anthrax, a top bioterror ... Anthim is a candidate for future acquisition into ... of critical medical supplies for biowarfare preparedness. Anthim ...
(Date:6/1/2015)... VEGAS , June 1, 2015 A ... make a landmark decision, with billion dollar implications, in ... Attorneys representing patients who suffered severe effects of bladder ... in a Las Vegas courtroom ... a jury decides, not the question of responsibility, but ...
(Date:6/1/2015)... 2015  MicroVention, Inc., a wholly owned subsidiary of ... that it will build its new 205,000 square-foot worldwide ... Aliso Viejo, CA , the city where the ... ceremony to commemorate the start of construction will be ... the site where the new headquarters building will be ...
Breaking Medicine Technology:U.S. Food And Drug Administration Accepts Biologics License Application For Anthim (Obiltoxaximab) 2U.S. Food And Drug Administration Accepts Biologics License Application For Anthim (Obiltoxaximab) 3Landmark Decision Expected In Actos Trial 2MicroVention to Locate Its New 205,000 Square-Foot Worldwide Headquarters At Summit Office Campus in Aliso Viejo 2MicroVention to Locate Its New 205,000 Square-Foot Worldwide Headquarters At Summit Office Campus in Aliso Viejo 3
... 2012  Delcath Systems, Inc. (NASDAQ: DCTH ) ... initial launch and training agreement for the Delcath Hepatic ... Roussy ("IGR"), a leading European cancer center located in ... Company will provide the IGR with logistics and clinical ...
... March 15, 2012 LifeSecure Insurance Company ... shop where caregivers can access quality home care products ... loved ones. LifeSecure,s Caregiver,s Marketplace offers ... aids and home modification tools to medical supplies. It ...
Cached Medicine Technology:Delcath Announces Agreement With Institut Gustave Roussy for Launch of Hepatic CHEMOSAT Delivery System in France 2Delcath Announces Agreement With Institut Gustave Roussy for Launch of Hepatic CHEMOSAT Delivery System in France 3Delcath Announces Agreement With Institut Gustave Roussy for Launch of Hepatic CHEMOSAT Delivery System in France 4LifeSecure Opens Online Caregiver's Marketplace 2
... (T4) is the primary active hormone synthesized ... gland [1]. T4 is synthesized via a ... by the follicular cells, (ii) iodination of ... to formation of 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT ...
... Triiodothyronine (T3) is produced primarily by 5-monodeioination ... the thyroid gland, T3 production occurs at ... that for T4. Release of T3 from ... ~5-8 micrograms/day as compared to 80-100 micrograms/day ...
... a monomeric protein produced and stored in ... is released from the pituitary into the ... regulatory control of hypothalamic somatostatin (SS) and ... frequency of GH release appears to be ...
... monomeric protein produced and stored in somatotrophs ... released from the pituitary into the bloodstream ... control of hypothalamic somatostatin (SS) and GH-releasing ... of GH release appears to be regulated ...
Medicine Products: