Navigation Links
Potential new treatment for deadly nipah and hendra viruses identified by Weill Cornell researchers

NEW YORK (Oct. 28, 2010) -- Scientists at Weill Cornell Medical College have identified a potential new treatment for the Nipah and Hendra viruses, two lethal and emerging viruses for which there is currently no treatment or vaccine available. The approach could also lead to new therapies for measles, mumps and the flu. The new research appears in today's edition of the prestigious journal Public Library of Science (PLoS) Pathogens.

The Nipah and Hendra viruses are members of the genus Henipavirus, a new class of virus in the Paramyxoviridae family, which includes the measles and the human parainfluenza virus (HPIV) that causes pediatric respiratory disease. The henipaviruses are carried by fruit bats (flying foxes) and are capable of causing illness and death in domestic animals and humans.

"These viruses are of great concern. The Hendra virus is highly fatal and is a considered a potential agent of bioterrorism. It currently poses a serious threat to livestock in Australia, where sporadic and deadly transmission to humans has occurred, with the potential for broader dissemination," says Dr. Matteo Porotto, the study's lead author and assistant professor of microbiology in pediatrics at Weill Cornell Medical College. "And the Nipah virus, which causes fatal encephalitis in up to 70 percent of human cases, causes seasonal outbreaks in Asia with person-to-person transmission now becoming a primary mode of infection. This virus could certainly cause global outbreaks."

Dr. Porotto and colleagues present a new strategy to prevent and treat these infections that may be broadly applicable for other "enveloped" viral pathogens, characterized by an outer wrapping that comes from the infected host cell. The new treatment was successfully tested in an animal model demonstrating central nervous system symptoms similar to those seen in humans.

Dr. Anne Moscona, professor of pediatrics and microbiology & immunology at Weill Cornell Medical College, vice chair of pediatrics for research at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, chief of pediatric infectious diseases and co-corresponding author of the paper, says, "It's crucial that we find treatments for the Nipah and Hendra viruses. In addition to acute infection, they can cause asymptomatic infection in as many as 60 percent of exposed people. They may also lead to late-onset disease or relapse of encephalitis years after initial infection, as well as persistent or delayed neurological problems."

According to Dr. Porotto, it is difficult to treat these pathogens because their "envelope" helps the virus survive and infect other cells. "We know that enveloped viruses must fuse their membrane with the target cell membrane in order to initiate infection, and blocking this step can prevent or treat infection, as has been clinically validated for the HIV virus."

Building on their past work, the team demonstrated in this study that the addition of a cholesterol group to HRC peptides that are active against Nipah virus dramatically increases their antiviral effect. The approach works by using the cholesterol-tagged peptides to target the membrane where the fusion occurs. There, the peptides interact with the fusion peptide before it inserts into the target cell membrane, disrupting the crucial membrane fusion process and preventing infection.

"The cholesterol-tagged HRC-derived peptides cross the blood-brain barrier and help prevent and treat the infection in animals for what would otherwise be fatal Nipah virus encephalitis," Dr. Porotto reports. "This suggests that they are promising candidates for the prevention or therapy of infection by Nipah and other lethal paramyxoviruses and may lead to better treatments for people affected by similar viruses including the measles, mumps and the flu."


Contact: Andrek Klein
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College

Related medicine news :

1. MRSA Strain With Outbreak Potential Among Reports at Disease Conference
2. Animal Study Explores Potential Gene Therapy for Depression
3. Adiponectin shows potential in blocking obesity-related carcinogenesis
4. Blocking an oncogene in liver cancer could be potential therapy option
5. Study details structure of potential target for HIV and cancer drugs
6. Study to investigate menstrual blood-derived stem cells as potential stroke therapy
7. Researchers identify potential new target for ovarian cancer
8. Toward safer plastics that lock in potentially harmful plasticizers
9. Purdue-IU team uncovers potential prostate cancer marker
10. A potential chemotherapeutic drug to treat hepatocellular carcinoma
11. Nutritions potential to save sight
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
Breaking Medicine Technology: