Navigation Links
Potential new strategy to reduce catheter blockage
Date:4/12/2011

Bacterial genes that make urine less acidic could be good targets to prevent catheter blockage, according to research presented at the Society for General Microbiology's Spring Conference in Harrogate. The findings could lead to new strategies to prevent serious infections, particularly in long-term catheterization patients.

Urinary catheters are devices used in hospitals and community care homes to manage a range of bladder conditions, and are commonly used to manage incontinence in elderly individuals for long periods of time. Scientists from the University of Brighton, led by Dr Brian Jones, are looking at the bacterium Proteus mirabilis - a common cause of urinary tract infections in patients undergoing long-term catheterization, which often leads to serious complications.

P. mirabilis cells can stick together on catheter surfaces where they form highly organized communities called biofilms. As the bacterium breaks down urea (using the enzyme urease) it causes the pH of urine to rise, leading to the formation of insoluble crystals which become trapped in the growing biofilm. The crystalline deposits can form a crust on the catheter and may eventually block urine flow from the bladder. If unnoticed, catheter blockage can lead to kidney and bloodstream infections, which ultimately may result in potentially fatal septic shock.

The team is identifying genes involved in P. mirabilis biofilm formation, and assessing their contribution to catheter blockage. The results show that biofilm-forming ability may be less important to catheter blockage than previously thought, and suggest that inhibiting the rise in urinary pH is a primary target for preventing catheter blockage. Nina Holling who is carrying out the research said, "In our experiments we have found biofilm-forming ability not to be the most important factor in catheter blockage. Although biofilm formation does play a role, the ability of P. mirabilis to increase urinary pH and form crystals seems to compensate for deficiencies in biofilm formation. However, much more work is required to fully understand the progression of these infections and biofilm formation may be more important in the early stages of infection."

Ms Holling explained the significance of the team's work. "Long-term catheterization is linked with an increased mortality rate among nursing home patients, and effective strategies to control these infections are urgently required," she said. "A greater understanding of how P. mirabilis forms biofilms and behaves within them will be important in developing such strategies. In the longer term, this would greatly benefit patients undergoing long-term catheterization by eliminating painful recurrent infections, which greatly reduce quality of life. In addition, the financial savings to the NHS would be significant."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert  

Related medicine news :

1. New potential atherosclerosis risk marker discovered
2. New drug shows potential for treatment-resistant leukemia
3. Scientists find potential benefit of hypericin for recurrent brain tumors
4. Study Probes Potential Link Between Welding, Parkinsons Disease
5. Researchers mimic bodys own healing potential to create personalised therapies for inflammation
6. U-M scientists find potential driver of some aggressive prostate cancers
7. Heart drug cuts prostate cancer risk; holds potential for therapeutic use
8. For potentially crippling dystonia, earlier deep brain therapy gets better, quicker results
9. In pilot study, screening detects potentially serious heart conditions in healthy children
10. New vaccine candidate shows strong potential to prevent highly contagious norovirus
11. Potential new treatment to reduce the burden of atherosclerosis in acute coronary syndrome patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Potential new strategy to reduce catheter blockage
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: