Navigation Links
Potential new role for red grape seeds in treatment of Alzheimer's disease
Date:6/17/2008

Mount Sinai researchers have discovered that polyphenolics derived from red grape seeds may be useful agents to prevent or treat Alzheimer's disease (AD). The new study entitled, "Grape derived polyphenolics prevent A oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease," was published in The Journal of Neuroscience. This new study explored the possibility of developing 'wine mimetic pills' that would replace the recommended beneficial glass of red wine a day for AD prevention.

"Alzheimer's disease is a neurodegenerative disorder characterized by progressive impairments in memory and cognition," said Dr. Giulio Maria Pasinetti, senior author and Director of the NCCAM-NIH funded Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer's Disease at Mount Sinai School of Medicine. "The study used a naturally derived grape seed polyphenolic extract and demonstrated its efficacy to reduce AD-type A neuropathology as well as cognitive deterioration in the Tg2576 AD mouse model. This natural compound is immediately available to be tested in AD clinical settings to prevent or treat AD."

Over the past few years researchers at Mount Sinai's Center of Excellence set out to determine whether the FDA's recommended daily servings of red wine (approximately one glass for women and two glasses for men), might have the same positive health effect that studies and surveys of populations had shown in the past. They are currently investigating nearly 5000 compounds contained in red wine.

This new study explored the possibility of developing 'wine mimetic pills' that would replace the beneficial glass of red wine a day for AD prevention. Dr. Pasinetti and his collaborator Dr. Jun Wang of Mount Sinai, through a partnership between the Research Center at Mount Sinai School of Medicine and Dr. Anil Shrikhande, the Director of the Polyphenolics Division of Constellation Brands, a major producer of biologically active grape products, tested the hypothesis that certain molecules contained in red wine, in particular in red grape seeds currently being developed with the name of Meganatural AZ, might offset disease progression in mice genetically modified to develop Alzheimer' disease.

"Meganatural AZ grape seed extracts significantly reduced Alzheimer's disease - type cognitive deterioration in the Alzheimer' disease mice through mechanisms that prevents the formation of a more complex form of a molecule known as amyloid in the brain," said Dr. Pasinetti. "The implications of these studies, however, are not limited to patients suffering from Alzheimer's disease. In fact, amyloid is present in everyone's brain and whenever it comes together in a more complex structure it makes the brain to function less efficiently like in Alzheimer' disease. As a result, Meganatural AZ compounds' ability to inhibit the formation of such 'more complex' amyloid structures suggests that Meganatural AZ from red grapes might even help prevent memory loss in people that did not yet developed Alzheimer's disease. "

Mount Sinai researchers believe they are one step closer to understanding the exact molecule in Meganatural AZ that is responsible for protecting memory and by extension closer to test whether Meganatural AZ can be used in patients affected by Alzheimer's disease.


'/>"/>

Contact: Mount Sinai Newsroom
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. UCLA study identifies designer estrogen as potential MS drug
3. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
4. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
5. Potential new approach to treat cognitive impairments in schizophrenia
6. Nosespray vaccine using aloe vera has exciting potential, researcher says
7. Network approach identifies potential breast cancer susceptibility gene
8. Liver fibrosis will be treated by a potential target
9. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
10. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
11. China Holdings, Inc. Announces 2nd Biomass Renewable Energy Project (Power Capacity: 50 MW); Total Potential: 100 MW in Biomass Energy Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... , ... Leading dental clinicians, Drs. Ashlyn Price, Autumn Mayers and Ron Adelman, ... systems. With advanced digital images and modeling capabilities, the dentists identify all of the ... oral health for those who are missing teeth in Midlothian, VA. , ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in the ... finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations which ...
(Date:6/20/2017)... ... June 20, 2017 , ... BrightStar Care Centerville/South Dayton, a ... the Joint Commission, which accredits and certifies nearly 21,000 healthcare organizations and programs ... a symbol of quality that reflects an organization’s commitment to meeting certain performance ...
(Date:6/20/2017)... ... June 20, 2017 , ... The law firm of ... installation as the president of the DuPage County Bar Association’s Board of Directors. Cassioppi ... June 9 at the Drake in Oak Brook. Momkus McCluskey Roberts LLC attorney Stacey ...
(Date:6/19/2017)... ... 19, 2017 , ... Intrinsic Clinical Systems announced it will ... actionable insights to improve health globally through the advancement of lifesaving medicines and ... faster, easier, and less painful. Attendees can visit Intrinsic’s booth showcasing its four ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away with ... platform is described by Forbes as "entering the life ... Medical Association as teaching "empathy to medical professionals in ... startup was recently named a finalist for the Department ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
(Date:6/7/2017)... June 7, 2017 Endo International plc (NASDAQ: ... 2017, the Hon. Joseph R. Goodwin , U.S. ... West Virginia , entered a case management ... Repair System Products Liability Litigation (the "MDL") that includes ... to provide expert disclosures on specific causation within one ...
Breaking Medicine Technology: