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Potential new role for red grape seeds in treatment of Alzheimer's disease
Date:6/17/2008

Mount Sinai researchers have discovered that polyphenolics derived from red grape seeds may be useful agents to prevent or treat Alzheimer's disease (AD). The new study entitled, "Grape derived polyphenolics prevent A oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease," was published in The Journal of Neuroscience. This new study explored the possibility of developing 'wine mimetic pills' that would replace the recommended beneficial glass of red wine a day for AD prevention.

"Alzheimer's disease is a neurodegenerative disorder characterized by progressive impairments in memory and cognition," said Dr. Giulio Maria Pasinetti, senior author and Director of the NCCAM-NIH funded Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer's Disease at Mount Sinai School of Medicine. "The study used a naturally derived grape seed polyphenolic extract and demonstrated its efficacy to reduce AD-type A neuropathology as well as cognitive deterioration in the Tg2576 AD mouse model. This natural compound is immediately available to be tested in AD clinical settings to prevent or treat AD."

Over the past few years researchers at Mount Sinai's Center of Excellence set out to determine whether the FDA's recommended daily servings of red wine (approximately one glass for women and two glasses for men), might have the same positive health effect that studies and surveys of populations had shown in the past. They are currently investigating nearly 5000 compounds contained in red wine.

This new study explored the possibility of developing 'wine mimetic pills' that would replace the beneficial glass of red wine a day for AD prevention. Dr. Pasinetti and his collaborator Dr. Jun Wang of Mount Sinai, through a partnership between the Research Center at Mount Sinai School of Medicine and Dr. Anil Shrikhande, the Director of the Polyphenolics Division of Constellation Brands, a
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Source:Eurekalert

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