Navigation Links
Potential drug target for PTSD prevention
Date:6/30/2014

Scientists at Yerkes National Primate Research Center, Emory University have identified a drug that appears to make memories of fearsome events less durable in mice.

The finding may accelerate the development of treatments for preventing PTSD (post-traumatic stress disorder). The drug, called osanetant, targets a distinct group of brain cells in a region of the brain that controls the formation and consolidation of fear memories.

The results were published in the journal Neuron.

"Potentially, drugs that act on this group of cells could be used to block fear memory consolidation shortly after exposure to a trauma, which would aid in preventing PTSD," says Kerry Ressler, MD, PhD, professor of psychiatry and behavioral sciences at Emory University School of Medicine and Yerkes National Primate Research Center. "PTSD is unique among psychiatric disorders in that we know when it starts at the time of the trauma. Finding ways to prevent its development in the first place in the emergency department or the battlefield - is an important and exciting avenue of research in this area."

The first author of the paper is postdoctoral fellow Ral Andero Gal, PhD.

Ressler and Andero were sifting through a list of many genes that are activated in the brains of mice after they learn to become afraid of a sound, because the sound is paired with a mild electric shock. The researchers were probing for changes in the central amygdala, a region of the brain known to regulate fear learning.

Out of thousands of genes they examined, their "top gene" was Tachykinin 2 or Tac2. The Tac2 gene was turned on more strongly during fear learning in mice that were previously exposed to a model of traumatic stress..

"The Tac2 gene is robustly activated after fear learning and belongs to a pathway that can be specifically blocked with a drug," Ressler says. "It was interesting that Tac2 is highly expressed in one particu
'/>"/>

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies potential treatment for lethal childhood leukemia
2. McMaster researchers find potential for new uses of old drug
3. Army researcher develops potential vaccine carrier
4. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
5. New study of NIH funding allocations suggests potential efficiency gains
6. A closer look at PARP-1 reveals potential new drug targets
7. Hybrid vaccine demonstrates potential to prevent breast cancer recurrence
8. VCU Massey Cancer Center sees potential in novel leukemia treatment
9. Misuse of over-the-counter pain medication is potential health threat
10. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
11. Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... A new study ... inmates who continued methadone maintenance treatment (MMT) during incarceration versus those subjected to ... to opiate use (1) and more likely to require hospitalization or emergency treatment ...
(Date:7/28/2015)... Savannah, Tenn. (PRWEB) , ... July 28, 2015 ... ... span July through October this year, as volunteers celebrate the 14th year of ... Morgan and Tracy Lawrence in downtown Savannah for this year’s main concert Saturday, ...
(Date:7/28/2015)... ... ... By 2016, the number of smartphones worldwide will surpass 2 billion. This ... personal basis, increasing customer loyalty. However, capitalizing on this is not always obvious. Companies ... more nimble competitors. , The Open Mobile Summit 2015 is an influential gathering of ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... Dr. ... the arrival of Dr. Sudeep Roy in July 2016. Coming to Austin from ... with Dr. Buckingham. The twelve-month long training is facilitated annually by the American ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... announced today that the company is in full support of National Immunization Awareness ... sometimes deadly diseases. To stay protected against serious illnesses like the flu, measles, ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 2Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 3Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 4Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3Health News:Open Mobile Media: Etsy, Google, The Weather Company, CBS, TaskRabbit and New York Times: Moving from Web to Mobile-First 2Health News:Open Mobile Media: Etsy, Google, The Weather Company, CBS, TaskRabbit and New York Times: Moving from Web to Mobile-First 3Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 2Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 3Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 2Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 3
... ... Farmed, Locally Grown, Organic Produce Plus Monthly Special Offers , ... (PRWEB) May 24, 2010 -- The Webb ... free program that provides shoppers with savings on organic and sustainably-farmed produce, plus access ...
... ... Helps Them Feel Better , ... (PRWEB) May 24, 2010 -- He,s no guru. And he’s not selling a philosophy, a ... for seven years. Still the stories surrounding this young Croatian have spawned hundreds of thousands ...
... women are less likely than Caucasians and men to ... blood. That is the conclusion of a new analysis ... journal of the American Cancer Society. The study,s results ... disparities exist in access to bone marrow transplantation and ...
... More research is needed to explore reasons why, study ... Men in a relationship with an HIV-positive woman face ... partner is pregnant, new research reveals. , The finding ... Conference in Pittsburgh. , The two-year study -- launched ...
... , ... Essence of Innovation and Survival , ... Placentia, CA (Vocus) May 23, 2010 -- Xlibris, the world’s leading print-on-demand self-publishing services ... the deck of creativity and innovation, a new book authored by Ralph M. Frid, Ph.D., ...
... ... Living a Healthy Long Life , ... Mariposa, CA (Vocus) May 23, 2010 -- Health enthusiasts and interested individuals are in ... Any Age. Packed with relevant knowledge and informative discussions, this book will help readers achieve ...
Cached Medicine News:Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 2Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 3Health News:Webb Ranch Farmers Market Introduces the Harvest Advantage Card 4Health News:Regular Guy "Braco" Healing Masses in Europe 2Health News:African-Americans and women are less likely to undergo bone marrow transplantation 2Health News:Female-to-Male HIV Transmission Risk Doubles During Pregnancy 2Health News:Xlibris Releases Trumping the Red Queen 2Health News:Xlibris Releases Trumping the Red Queen 3Health News:The Secret on How to Live Healthy at Any Age 2
(Date:7/28/2015)... 2015 Amgen (NASDAQ: AMGN ) announced ... per share dividend for the third quarter of 2015. ... to all stockholders of record as of the close ... About Amgen Amgen is committed to unlocking the potential ... discovering, developing, manufacturing and delivering innovative human therapeutics. This ...
(Date:7/28/2015)...   Regulus Therapeutics Inc . ( NASDAQ: RGLS ... of innovative medicines targeting microRNAs, today announced that it ... ended June 30, 2015 on Tuesday, August 4, 2015, ... Regulus will host a conference call and webcast on ... Time to discuss its second quarter 2015 financial results ...
(Date:7/28/2015)... Calif. , July 28, 2015 On ... Corp., the parent company of CPI International, Inc. (CPI), ... quarter ended July 3, 2015 with the Securities and ... its results for the quarter.  At 11 a.m. (EDT) ... telephonic conference call in conjunction with this release that ...
Breaking Medicine Technology:Amgen Announces 2015 Third Quarter Dividend 2Amgen Announces 2015 Third Quarter Dividend 3Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2015 Financial Results Webcast and Conference Call 3CPI International To Announce Third Quarter 2015 Financial Results 2
... Cell Therapeutics, Inc. (CTI),(Nasdaq and MTA: CTIC) today announced that the following presentations,will ... formerly XYOTAX(TM)),at the 44th American Society of Clinical Oncology (ASCO) Annual Meeting,May 30 through ... Poster # ... (Abstract#) Sat., ...
... First and Only Treatment for Hunter Syndrome Now Approved in ... ... Worldwide, BASINGSTOKE, England and CAMBRIDGE, Massachusetts, May ... company, announced that ELAPRASE(R),(idursulfase), a human enzyme replacement therapy for ...
Cached Medicine Technology:Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 2Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 3Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 2Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 3Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 4Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: