Navigation Links
Potential cause of severe sleep disorder discovered, implications for Parkinson's disease
Date:6/15/2011

TORONTO, ON Researchers at the University of Toronto are the first to indentify a potential cause for a severe sleep disorder that has been closely linked to Parkinson's disease and other neurodegenerative diseases.

"Our research is the first to establish a potential genetic link to human REM sleep behaviour disorder (RBD). That's important because between 60 and 80 per cent of people diagnosed with human RBD develop Parkinson's disease or other neurodegenerative disorders later in life," says Dr. John Peever, lead author of the study that recently appeared in The Journal of Neuroscience.

Rapid-eye-movement sleep behaviour disorder (RBD) is most often characterized by violent movements that occur during dreaming sleep, also called rapid-eye-movement sleep. People who suffer from RBD do not experience normal muscle paralysis that prevents them from enacting their dreams and they often hurt themselves or their bed partners with their rapid, forceful movements. In some cases, patients need to be tied to their bed to prevent serious injury to themselves or their bedpartners.

Peever's team focused on investigating a genetic cause of RBD because the underlying cause of this disorder is unknown. There is evidence indicating that reduced brain inhibition could cause RBD, so Peever's team genetically reduced brain inhibition in mice and then recorded their sleep and muscle activity.

"We found that mice with reduced brain inhibition acted just like human RBD patients and they moved violently during REM sleep," says Peever. "This link strongly suggests that patients with RBD may also have impaired brain inhibition."

They also found that RBD symptoms in mice could be alleviated by giving them clonazepam a drug used to treat human RBD.

Peever's research underscores the importance of identifying a cause of RBD as 60 80 per cent of RBD sufferers subsequently develop Parkinson's.

"Treating RBD could have
'/>"/>

Contact: Michael Kennedy
m.kennedy@utoronto.ca
416-946-5025
University of Toronto
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
2. Potential new target for smoking cessation without weight gain
3. Decade of vaccines has potential to save lives, but challenges ahead
4. Scientists unlock potential of frog skin to treat cancer
5. Tens of thousands of lives could potentially be saved by key heart failure therapies
6. Calorie-burning brown fat is a potential obesity treatment, researchers say
7. Cause and potential treatment found for cancer drugs kidney toxicity
8. Potential new drug candidate found for Alzheimers disease
9. The Potential to Modify the Course of Parkinsons Disease
10. Potentially Toxic Flame Retardants Found in Baby Products
11. Half of prostate cancers could potentially benefit from new type of cancer drugs, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... HealthDay Reporter FRIDAY, Oct. ... cold sores -- herpes simplex -- might increase the risk ... In fact, being a carrier of certain antibodies to the ... found. "The identification of a treatable cause [herpes ... said lead researcher Dr. Hugo Lovheim, an associate professor in ...
(Date:10/25/2014)... (HealthDay News) -- A large influx of international aid ... avoid tens of thousands of deaths from the widening ... Using a specially designed mathematical model, the ... in just one densely populated county of hard-hit Liberia ... Monrovia. The researchers said that if international aid ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- October,s shorter, ... as seasonal affective disorder, according to an expert. ... SAD, may feel overly tired, lack motivation and even ... SAD can lead to suicide, said Dr. Angelos Halaris, ... neurosciences at Loyola University Chicago Stitch School of Medicine. ...
(Date:10/22/2014)... On October 22, CBS will air an ... both fictional and real. The Charles E Holman ... to advocacy and philanthropy in the battle against Morgellons ... to impart truth and clarity about this misunderstood and ... misconceptions about Morgellons Disease (MD) and most ...
(Date:10/22/2014)... 2014 For Dr. Iris Hunter, a job ... an extension of her life’s mission. Her extensive experience in ... owner of FirstLight HomeCare, make it clear that Hunter’s mission ... that my work makes a difference in the lives of ... so after much research, I felt ready to start on ...
Breaking Medicine News(10 mins):Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2
... treatment, study shows , TUESDAY, Jan. 26 (HealthDay News) ... to lower high blood glucose levels caused by corticosteroid ... study has found. , The death rate for septic ... is 60 percent within a short period, according to ...
... CHICAGO , Jan. 26 After a week of trial ... $1-million insurance policy on January 20, 2010 , to settle a ... the physician,s failure to timely diagnose bladder cancer. , In Russell v. ... Carmen Russell and Daniel Russell, Jr. , the wife and ...
... , International Guidelines Ensure Maximum Protection of Children ... Just weeks after the United Nations General Assembly adopted a resolution ... the international community is struggling to provide appropriate care and protection ... Haiti . The Guidelines are the first international document on ...
... NASHVILLE, Tenn. , Jan. 26 Saint ... clinical quality among the top five percent in the nation ... is one of only 269 hospitals that received this distinction ... , The study by HealthGrades, the leading independent healthcare ratings ...
... 26 President Obama will need several props to get ... a box of teabags, a paper shredder, and a new "No ... by taking the 2,074 page Senate health bill and stuffing it ... a 20-page bill in plain, honest English," says Betsy McCaughey ...
... heart defects (CHD) are the most common birth ... births with one third of affected children requiring ... combined with developmental expectations for independence, behavioral self-regulation ... identification of neurobehavioral symptoms in some survivors. A ...
Cached Medicine News:Health News:Intensive Insulin Therapy Won't Boost Septic Shock Survival 2Health News:Romanucci & Blandin, LLC, Reaches $1 Million Settlement in Medical Negligence Lawsuit 2Health News:International Community Calls for Prevention of Further Trauma in Haiti 2Health News:International Community Calls for Prevention of Further Trauma in Haiti 3Health News:Saint Thomas Hospital Ranked Top Five Percent in Nation for the Second Consecutive Year According to Quality Study 2Health News:Props for the President at His State of the Union Address 2Health News:Bypass procedure used during infant heart surgery does not impair later neurological outcomes 2
(Date:10/22/2014)... , October 22, 2014 Investor-Edge ... Inc. (NASDAQ: FOLD ), Progenics Pharmaceuticals Inc. ... THLD ), Idera Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... 21, 2014, the NASDAQ Composite ended at 4,419.48, up ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  Paper ... products, has developed APLS ® Body Guard ... minimizes the spread of bacteria and virus while ... APLS Body Guard Bio features a rugged, external ... edges that create a leak-proof inner chamber that ...
(Date:10/22/2014)... , October 22, 2014 ... ), a clinical-stage pharmaceutical company focused on ... reported positive top-line clinical results from its Phase ... oral insulin capsules, to treat type 1 diabetes. The ... States under a U.S. Food and ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4
... 2010 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc. ("China-Biotics" or "the ... developer, manufacturer and distributor of probiotics products in ... Company,s research and development department presented at the ... Equipment seminar in Hangzhou, China on November 21st. ...
... (OTC Bulletin Board: GOVX ) (the "Company"), an ... Immunodeficiency Virus), has appointed David A. Dodd as Chairman of ... Hildebrand is stepping down as Chairman and will remain on ... a consultant to the Company. Mr. Dodd, age ...
Cached Medicine Technology:China-Biotics Attended National Probiotics Seminar 2China-Biotics Attended National Probiotics Seminar 3David A. Dodd Appointed Chairman of the Board of GeoVax Labs 2David A. Dodd Appointed Chairman of the Board of GeoVax Labs 3David A. Dodd Appointed Chairman of the Board of GeoVax Labs 4
... CCR Medical's Articulating Tip Laryngoscopes ... in the Industry. The articulating ... by providing an improved view ... and Fiber Optic styles. We ...
German Style MacIntosh Fiber Optic Blade Laryngoscopes...
CCR Medical fiberoptic green system laryngoscope handles., ,OUTSTANDING PERFORMANCE, QUALITY, AND PRICING MAKE OUR FIBEROPTIC SELECTION MOST ECONOMICAL....
CCR Medical fiberoptic green system laryngoscope handles., ,OUTSTANDING PERFORMANCE, QUALITY, AND PRICING MAKE OUR FIBEROPTIC SELECTION MOST ECONOMICAL....
Medicine Products: