Navigation Links
Potential cause of severe sleep disorder discovered, implications for Parkinson's disease
Date:6/15/2011

TORONTO, ON Researchers at the University of Toronto are the first to indentify a potential cause for a severe sleep disorder that has been closely linked to Parkinson's disease and other neurodegenerative diseases.

"Our research is the first to establish a potential genetic link to human REM sleep behaviour disorder (RBD). That's important because between 60 and 80 per cent of people diagnosed with human RBD develop Parkinson's disease or other neurodegenerative disorders later in life," says Dr. John Peever, lead author of the study that recently appeared in The Journal of Neuroscience.

Rapid-eye-movement sleep behaviour disorder (RBD) is most often characterized by violent movements that occur during dreaming sleep, also called rapid-eye-movement sleep. People who suffer from RBD do not experience normal muscle paralysis that prevents them from enacting their dreams and they often hurt themselves or their bed partners with their rapid, forceful movements. In some cases, patients need to be tied to their bed to prevent serious injury to themselves or their bedpartners.

Peever's team focused on investigating a genetic cause of RBD because the underlying cause of this disorder is unknown. There is evidence indicating that reduced brain inhibition could cause RBD, so Peever's team genetically reduced brain inhibition in mice and then recorded their sleep and muscle activity.

"We found that mice with reduced brain inhibition acted just like human RBD patients and they moved violently during REM sleep," says Peever. "This link strongly suggests that patients with RBD may also have impaired brain inhibition."

They also found that RBD symptoms in mice could be alleviated by giving them clonazepam a drug used to treat human RBD.

Peever's research underscores the importance of identifying a cause of RBD as 60 80 per cent of RBD sufferers subsequently develop Parkinson's.

"Treating RBD could have direct implications for understanding and perhaps treating Parkinson's disease," says Peever.


'/>"/>

Contact: Michael Kennedy
m.kennedy@utoronto.ca
416-946-5025
University of Toronto
Source:Eurekalert

Related medicine news :

1. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
2. Potential new target for smoking cessation without weight gain
3. Decade of vaccines has potential to save lives, but challenges ahead
4. Scientists unlock potential of frog skin to treat cancer
5. Tens of thousands of lives could potentially be saved by key heart failure therapies
6. Calorie-burning brown fat is a potential obesity treatment, researchers say
7. Cause and potential treatment found for cancer drugs kidney toxicity
8. Potential new drug candidate found for Alzheimers disease
9. The Potential to Modify the Course of Parkinsons Disease
10. Potentially Toxic Flame Retardants Found in Baby Products
11. Half of prostate cancers could potentially benefit from new type of cancer drugs, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 30, 2016 , ... World ... the Pick Up Springboard, an automotive invention that improves the storage features of ... worth $162 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic Healing, ... addition Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization ... optimization products to the store is just one more way Shamangelic Healing supports ...
(Date:4/29/2016)... Sterling, VA (PRWEB) , ... April 29, 2016 ... ... Americans with student loans more flexibility in repaying their loans, more information about ... at a time when total outstanding student loan debt, including federal and private ...
(Date:4/29/2016)... ... 2016 , ... The Wharton School of the University ... of the 2016 Wharton Business Plan Competition —as well as the Wharton ... the Committee Award for Most ‘Wow Factor,’ making them the first team in ...
(Date:4/29/2016)... ... ... Dr. Robert Mondavi, one of the dentists in Torrance , is now ... as more patients are discovering the many different ways they can change and improve ... to them and which ones might work for their smiles. , “One of ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)...  Bayer Animal Health today announced that ... of Florida College of Veterinary Medicine, is the ... Award (BECA). Brittany was selected from entries representing ... of $70,000 in scholarship funds through the 2016 ... provided a total of $232,500 in scholarship awards ...
(Date:4/27/2016)... Oasmia Pharmaceutical AB (NASDAQ: ... new generation of drugs within human and veterinary ... Paclical/Apealea in the Phase III study that included ... cancer. These preliminary results showed non-inferiority between the ... versus Taxol in combination with carboplatin. In fact, ...
(Date:4/27/2016)... , April 27, 2016 ... announced the launch of a Phase 2 clinical study ... hearing in patients undergoing cochlear implantation (CI) surgery. This ... patients in Germany and ... the middle ear at the time of surgery. "Despite ...
Breaking Medicine Technology: