Navigation Links
Potential cause of severe sleep disorder discovered, implications for Parkinson's disease
Date:6/15/2011

TORONTO, ON Researchers at the University of Toronto are the first to indentify a potential cause for a severe sleep disorder that has been closely linked to Parkinson's disease and other neurodegenerative diseases.

"Our research is the first to establish a potential genetic link to human REM sleep behaviour disorder (RBD). That's important because between 60 and 80 per cent of people diagnosed with human RBD develop Parkinson's disease or other neurodegenerative disorders later in life," says Dr. John Peever, lead author of the study that recently appeared in The Journal of Neuroscience.

Rapid-eye-movement sleep behaviour disorder (RBD) is most often characterized by violent movements that occur during dreaming sleep, also called rapid-eye-movement sleep. People who suffer from RBD do not experience normal muscle paralysis that prevents them from enacting their dreams and they often hurt themselves or their bed partners with their rapid, forceful movements. In some cases, patients need to be tied to their bed to prevent serious injury to themselves or their bedpartners.

Peever's team focused on investigating a genetic cause of RBD because the underlying cause of this disorder is unknown. There is evidence indicating that reduced brain inhibition could cause RBD, so Peever's team genetically reduced brain inhibition in mice and then recorded their sleep and muscle activity.

"We found that mice with reduced brain inhibition acted just like human RBD patients and they moved violently during REM sleep," says Peever. "This link strongly suggests that patients with RBD may also have impaired brain inhibition."

They also found that RBD symptoms in mice could be alleviated by giving them clonazepam a drug used to treat human RBD.

Peever's research underscores the importance of identifying a cause of RBD as 60 80 per cent of RBD sufferers subsequently develop Parkinson's.

"Treating RBD could have direct implications for understanding and perhaps treating Parkinson's disease," says Peever.


'/>"/>

Contact: Michael Kennedy
m.kennedy@utoronto.ca
416-946-5025
University of Toronto
Source:Eurekalert

Related medicine news :

1. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
2. Potential new target for smoking cessation without weight gain
3. Decade of vaccines has potential to save lives, but challenges ahead
4. Scientists unlock potential of frog skin to treat cancer
5. Tens of thousands of lives could potentially be saved by key heart failure therapies
6. Calorie-burning brown fat is a potential obesity treatment, researchers say
7. Cause and potential treatment found for cancer drugs kidney toxicity
8. Potential new drug candidate found for Alzheimers disease
9. The Potential to Modify the Course of Parkinsons Disease
10. Potentially Toxic Flame Retardants Found in Baby Products
11. Half of prostate cancers could potentially benefit from new type of cancer drugs, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... ... that Lake City Bank has selected IFN as a fiber transport provider. IFN ... in increased efficiencies and reduced costs. , “IFN provides fiber transport ...
(Date:5/25/2016)... ... 2016 , ... CloudLIMS, joins an elite number of companies that have earned ... of 2016 by CIOReview. , In a deliberate session with the honorary industrial experts, ... has been concluded with. The positioning is based on evaluation of CloudLIMS’ specialties in ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... and products in the developing world, is pleased to release their 2015 global ... 5 million unwanted pregnancies, almost 14,000 maternal deaths and 3.8 million unsafe abortions ...
(Date:5/25/2016)... ... 2016 , ... Casa Velas, an adults-only boutique hotel in Puerto Vallarta, Mexico, ... new wellness suites . The two 1,350 sq. ft. suites which debuted in ... and insuite amenities, from a custom soap selection and in-suite exercise kit to a ...
(Date:5/25/2016)... ... ... For more than fifty years, we've suffered whiplash as each new scientific study seemed to ... latest nutritional advice – advice that was supposed to keep us healthy and slim. And ... adults are considered to be overweight and more than 1 in 3 adults are considered ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice president of ... In his new role, Marziani will lead the company,s business development and sales team, ... outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help doctors ... a global scale. Medical professionals from Europe , ... the US have already signed up for the app, which combines ... environment. Education  "Imagine a doctor for Medicines ... at Harvard to treat a bomb victim via live streaming - ...
(Date:5/23/2016)... 23, 2016 Transparency Market Research ... Pancreatic Insufficiency Market - Global Industry Analysis, Size, Share, ... to the report, the exocrine pancreatic insufficiency market is ... 2015 to 2023 to reach US$2.85 Bn by 2023. ... characterized by the deficiency of the exocrine pancreatic enzymes, ...
Breaking Medicine Technology: