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Potential blood test for chronic sinusitis identified
Date:4/14/2008

s for inflammation, mucus thinners, saline irrigation, etc. Its difficult to show drugs are effective because its difficult to group patients together and measure their disease, says Dr. Kountakis.

He hopes further studies will enable both, revealing signature protein profiles for different types of chronic sinusitis as well as the degree of disease. The bottom line is we want to group patients according to their disease rather than just the general term chronic sinusitis, Dr. Kountakis says. If we can find a way to classify patients, group them together based on the specific disease they have, maybe we can get better outcomes and treat patients with better efficiency.

These objective measures should allow monitoring the effectiveness of current therapies and objectively reviewing new ones, he says.

In fact, even getting a handle on disease incidence is tough. The National Health Interview Survey, based on self-reports, says 14 to 16 percent of people in the United States have chronic sinusitis. A population-based study of the Olmsted County, Minnesota published in 2004 in Archives of Otolaryngology-Head & Neck Surgery put the incidence at 2 percent.

For this study, researchers analyzed protein expression in the blood using surface enhanced laser desorption ionization time-of-flight mass spectroscopy or SELDI-TOF-MS. The test is about 88 percent accurate.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4412
Medical College of Georgia
Source:Eurekalert  

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