Navigation Links
Potential autoimmunity-inducing cells found in healthy adults
Date:12/22/2008

It's not just patients with autoimmune diseases like lupus and rheumatoid arthritis (RA) that have self-attacking immune cellshealthy people have them too, according to a new report in the Journal of Experimental Medicine. In healthy adults, however, these cells are maintained in an 'off' state, perhaps explaining their innocuous nature. Whether these cells are the true predecessors of the self-attacking cells prevalent in lupus and RA and, if so, what prevents them from causing disease in everyone is not yet known. The new study will appear online on December 22nd.

As antibody-producing B cells develop in the bone marrow, the body tests them to determine whether their antigen receptors are apt to confuse self tissues for intruders. If so, their receptors are either rearranged to make new, non-autoreactive versionsa process called 'receptor editing'or the cells are killed off while still in the bone marrow. Yet a minority manages to escape, slipping into the body as mature B cells with a propensity for self-attack.

Using mice, researchers have shown that these self-reactive escapees are arrested in a state of anergy that prevents them from mounting an immune attack. But, until now, a similar population of cells had never been found in humans. In the new study, a team of researchers led by J. Andrew Duty at the Oklahoma Medical Research Foundation have pin-pointed a similar population of anergic B cells in the blood of healthy adults, where they accounted for 2.5% of B cells in the circulating blood.

Although these anergic cells did not appear to cause problems in healthy people, the authors demonstrated their potential to produce self-reactive antibodies by providing the cells with a strong stimulus in cell culture. The potential to produce these trouble-making antibodies lead the authors to suspect that these cells may contain the precursors for the self-attacking B cells in patients with autoimmune diseases. Perhaps anergy somehow breaks down in these patients, allowing self-sabotaging cells to run free.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert

Related medicine news :

1. Parker College of Chiropractic Education Launches Recruiting Campaign for Career Changers and Potential Students
2. New psychotherapy has potential to treat majority of cases of eating disorders
3. Mayo researchers find potential links between breast density and breast cancer risk
4. Hissey Kientz, LLP Warns Duragesic Patch Users About Potential Health Risks of Fentanyl Overdose
5. ITRI: Taiwan Focuses on C Liver Medic's R&D to Reach USD 6 Billion Potential Market in the World
6. Light shines for potential early cancer diagnosis technique
7. Drug Abuse and Violence Prevention Program Generates $16 Million in Potential Savings
8. UCSD researchers identify potential new drug target for chronic leukemia
9. TargetScan Evaluation is Shown to Deliver Potentially Higher Cancer Detection Rate and More Accurate Assessment of Grade
10. Cord Blood America Posts Letter to Shareholders: New Administrations Potential Enhanced Stem Cell Research Initiative Should Benefit the Company and Its Shareholders
11. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new ... affiliate in Latin America . ... ... ... ...
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... rough waters, but it continues to present great opportunities ... featured companies for today: Intrexon Corp. (NYSE: ... ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... Learn more about these stocks and receive your complimentary ...
Breaking Medicine Technology: