Navigation Links
Potential Brain Cancer Drug for Children May Damage Bones
Date:3/10/2008

od development.

The drug used by Curran's group acts on the hedgehog (Hh) pathway, which is known to play multiple roles during the development of mammals. Mutations of genes along that pathway lead to different cancers, including medulloblastoma, the most common cancerous brain tumor in children. Because conventional treatment with surgery, radiation and chemotherapy causes serious long-term side effects such as ataxia (a movement disorder) and cognitive impairments, the researchers sought novel, less toxic treatments for medulloblastoma.

In 2001, using genetic engineering, Curran bred mice to develop medulloblastoma. He then treated those mice with HhAntag, which had previously been developed by a biotech company for treating skin cancer in adults. In 2004, while at St. Jude's Children's Research Hospital, Curran reported highly promising results from the mouse studies. At high doses, the drug caused the tumors to shrink and in some cases, disappear entirely. The treated mice also survived much longer than untreated mice, with no serious side effects.

The drug seemed to be an unusually strong candidate for trials in children with the type of medulloblastoma having gene mutations on the Hh pathway--about a third of cases.

However, when Curran's group tested the agent on young mice (10 to 14 days old, in contrast to the adult mice tested previously), they found an unpleasant surprise: serious impairments to developing bones. The mice were smaller, with lower weight and shorter bones than untreated mice, and the effects were not reversible. Even four doses of the drug permanently stunted their growth. "We already knew that the same biological pathway involved in the growth of tumors was also involved in bone development," said Curran, "but we did not expect temporary inhibition to cause an irreversible change in bone growth."

While the current studies were disappointing, said Curran, they do not totally rule out a future r
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. UCLA study identifies designer estrogen as potential MS drug
3. Office-Based Medical Treatment and Internet Resources Are Potential Solution to Rising Painkiller Misuse Among Teens, Young Adults
4. Common abdominal pain may be due to a potentially treatable newly recognized inflammatory reaction
5. Potential new approach to treat cognitive impairments in schizophrenia
6. Nosespray vaccine using aloe vera has exciting potential, researcher says
7. Network approach identifies potential breast cancer susceptibility gene
8. Liver fibrosis will be treated by a potential target
9. Researchers study potential health benefits of natural chemicals in muscadine grape seeds
10. Jefferson researchers find stem cells in degenerating spinal discs, potential for repair
11. China Holdings, Inc. Announces 2nd Biomass Renewable Energy Project (Power Capacity: 50 MW); Total Potential: 100 MW in Biomass Energy Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, iFitDress.com, the ... for women, has announced its new selection of black ... are on sale now; they are available at discounted prices, ... says, “The promotion will last for three weeks only. You ... market. Those who are interested in our new items can ...
(Date:12/25/2014)... Hills, California (PRWEB) December 25, 2014 ... her home in Woodland Hills, California after an 8 ... passed away on Christmas Eve evening in her home ... with aggressive metastatic breast cancer. , ... for over forty years, she pioneered and championed many ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- Overeating is common during ... eat in moderation, an expert says. "Don,t arrive at ... calories if you know you,ll be attending a party, but ... Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount Kisco, ... to eat healthy during the day and even to have ...
(Date:12/25/2014)... 25, 2014 “ SmileStix ” was featured ... the latest and coolest mobile applications on the iOS, Android, ... host of NewsWatch, conducted the app review and shared with ... personal stickers. , The old saying goes, “A picture says ... words that can describe a single image, because each picture ...
Breaking Medicine News(10 mins):Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... Oct. 19 Broadband Wireless,International Corporation (Pink Sheets: ... round discussions with Mr. Kenneth Andam in,connection with ... Owing to a continuing business relationship,connecting Mr. Andam ... a,series of good faith negotiations have commenced between ...
... (Nasdaq: ARNA ) announced today that it has ... with the Securities,and Exchange Commission relating to a proposed ... connection with this offering,Arena plans to grant to the ... 1,500,000 shares of common stock to cover over-allotments, if,any. ...
... Oct. 19 Video games it is not. ... (VR),applications have experienced double-digit growth both worldwide and ... and the 2010 U.S. market for virtual,reality in ... grow to,$290 million, according to Virtual Reality Market ...
... less the idea bothered her , , FRIDAY, Oct. 19 ... idea of childlessness than men, new research shows, and ... each gender views the pressures of parenthood. , "On ... parenthood mean different things," said study author Tanya Koropeckyj-Cox. ...
... in Congress, caregivers and advocates,to visit Capitol Hill Tuesday, ... nursing homes, WASHINGTON, Oct. 19 With political ... about the impact of,private equity buyouts of nursing homes, ... in D.C. on Monday where they will hold a,demonstration ...
... under 6, advisers say., , , FRIDAY, Oct. 19 (HealthDay News) ... panel on Friday recommended a ban on over-the-counter cough and ... number of studies that showed the remedies were no better ... be tested on children to see if they are effective. ...
Cached Medicine News:Health News:Broadband Wireless International Corporation Announces the Commencement of Good Faith Talks with HealthPitch 2Health News:Arena Pharmaceuticals Announces Public Offering of Common Stock 2Health News:Virtual Reality Technology Finds Ready and Willing Market in Healthcare 2Health News:Childlessness Bothers Men More Than Women 2Health News:Childlessness Bothers Men More Than Women 3Health News:FDA Panel Recommends Ban on Cold Medicines for Kids 2Health News:FDA Panel Recommends Ban on Cold Medicines for Kids 3Health News:FDA Panel Recommends Ban on Cold Medicines for Kids 4
(Date:12/24/2014)... Dec. 24, 2014  The International Trade Commission (ITC) issued ... against BMC Medical. In a notice issued on December 23, ... ResMed,s patent on its humidifier was invalid. BMC ... win". "We are very excited with the ITC,s decision in ... we have taken since the very beginning on the key ...
(Date:12/24/2014)... 23, 2014 PuraMed BioScience®, Inc., (OTC Pink: ... medicinal and healthcare products, announced it received the initial ... hemp-based, advanced headache relief product, for planned distribution to ... Colorado , Washington State , ... the MigraPure H Advanced headache relief gel formulation completed, ...
(Date:12/24/2014)... Mass. , Dec. 23, 2014   ... ), a biopharmaceutical company developing therapeutic products for ... Medicines Agency (EMA) of the Marketing Authorization Application ... EMA recently granted the company,s request for accelerated ... EMA,s regulatory review time.   The ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... improvement solutions provider General Physics Corporation (GP) , ... GPX ), announced today that it has formalized ... (Seville, Spain), a leading European technology company, to provide ... control technologies to optimize fuel costs and further reduce ...
... Nov. 17, 2011 SurgiCount Medical, Inc., the ... (OTCBB: PSTX, OTCQB: PSTX) today announced that it ... alliance.  A collaboration of more than 2,500 hospitals ... alliance seeks to lead the transformation to high ...
Cached Medicine Technology:GP and INERCO Form Strategic Alliance to Assist Clients with Optimizing Fuel Costs and Decreasing Emissions 2GP and INERCO Form Strategic Alliance to Assist Clients with Optimizing Fuel Costs and Decreasing Emissions 3SurgiCount Medical Announces Agreement with Premier Healthcare Alliance 2SurgiCount Medical Announces Agreement with Premier Healthcare Alliance 3
Ideal for use with our High Beam headlight. Rotating Turret allows use with other manufacturer's cables. Infinite intensity control. Excellent color definition (6000 K Color Temperature)....
... Lite positions directly over one,eye permitting ... lens an exclusive feature ,resulting ... optic light that penetrates,deep into a ... swivel mount enables the,surgeon to rotate ...
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Halogen III Classic is,lightweight, comfortable and durable....
... InterGro DBM putty is a ... most trusted names in human tissue ... in bone grafting technology. InterGro ... lipid carrier (lecithin) to deliver a ...
Medicine Products: