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Potential Alzheimer's disease risk factor and risk reduction strategies become clearer
Date:7/14/2014

, 96.5 percent of whom were male.

The researchers examined eight years of the veterans' medical records. After controlling for variables such as gender, income, education, and health status, they found that veterans who had a diagnosis of non-specific sleep disturbance, apnea, or insomnia at baseline had a 30 percent increased risk of dementia compared with veterans with no diagnosed sleep problems. They also found that veterans with both PTSD and sleep disturbance had an 80 percent increased risk of dementia.

"This is the first investigation into the link between sleep disturbance and dementia in a large cohort of older, mostly male veterans," said Yaffe. "Further research is needed to clarify the role of sleep disturbance as either a risk factor for, or an early symptom of, dementia among veterans, and in other populations as well."

In People 90 and Older, Late Onset Hypertension May Protect Against Dementia

While hypertension during midlife is considered to increase risk for Alzheimer's and other dementia, there is emerging research evidence suggesting that its role in dementia risk may change over time, and may instead help protect against dementia in people age 90 and over, known as the "oldest old." Maria Corrada, M.S., Sc.D. of the University of California, Irvine and colleagues investigated the relationship between risk of dementia, age of the onset of hypertension, and blood pressure measurements in the oldest old, and reported the results at AAIC 2014.

The researchers followed 625 participants every six months for up to ten years in The 90+ Study, an ongoing longitudinal study of people age 90 and older. At enrollment, participants did not have dementia and were 93 years old on average; 69 percent were female. The researchers found that participants with a hypertension onset age of 80 to 89 years had a significantly lower risk of developing dementia compared with participants with no history of hyper
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Contact: Alzheimer's Association Media Line
media@alz.org
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Alzheimer's Association
Source:Eurekalert

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