Navigation Links
Potent peptides inhibit HIV entry into cells
Date:10/10/2007

UPTON, NY -- Based in part on protein structures determined at the National Synchrotron Light Source (NSLS) at the U.S. Department of Energy's Brookhaven National Laboratory, scientists at the University of Utah have developed new peptides that appear to be significantly more effective at blocking HIV's entry into cells than other drugs in their class. In a paper being published online by the Proceedings of the National Academy of Sciences the week of October 8, 2007, the researchers say these peptides are sufficiently potent to begin pre-clinical studies as a new class of agents for the prevention and treatment of HIV/AIDS.

"Our 'D-peptides' offer several potential therapeutic advantages over existing peptide entry inhibitors, which are costly, require high dose injections, and suffer from the emergence of drug-resistance," said University of Utah biochemist Michael S. Kay, lead author on the paper. "In contrast, our D-peptides resist degradation, so they have the potential to be administered by mouth and last longer in the bloodstream. Since these inhibitors have a unique inhibitory mechanism, they should work well in combination with existing HIV inhibitors."

The researchers were particularly interested in developing drugs to bind to an essential "pocket" structure found in all HIV strains that was previously identified as a promising drug target using structures determined at Brookhaven's NSLS. Numerous previous attempts to target this pocket failed to produce potent and non-toxic pocket-specific entry inhibitors.

In the current work, the researchers used a high-throughput technique to screen a "library" containing hundreds of millions of peptides to identify the rare peptides that would bind to the pocket structure and inhibit HIV entry.

After identifying the most promising candidate peptides, the researchers analyzed the structure of these peptides bound to the target protein using x-ray crystallography at the NSLS. In
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Potential New Cancer Gene Identified
2. Hepatitis E virus made impotent
3. Lack of Smell And Its Potential Risks
4. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years
5. The Potential Of Cadaver Transplantation Programme In India
6. Unwed mothers find it difficult to attract potential life partner
7. Dermaseptins: Potent vaginal contraceptives
8. The potent anti-leukemia activity of Berbamine
9. Another Potential Of Stem Cells Discovered: Used For Growing Cartilage
10. Unpasteurised juices found to be potential health hazards
11. The many facets of milk and its health potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... (PRWEB) April 21, 2015 The Northeast ... the beautiful Governor’s Academy prep school in Byfield, MA. ... 10-12, 2015, for boys entering grades 6-12. , The ... supplement the players’ fall coaching. , Offensive ... Not only are these the most unsung positions on ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Dr. Zain ... just released an interesting infographic that takes a close look ... , The new infographic, which appears on both Dr. Kadri’s ... Rise of Plastic Surgery in the Age of the Selfie.” ... in Beverly Hills to a variety of A-list patients, ...
(Date:4/21/2015)... Freeslate, Inc ., the leading provider ... that the Centre for Catalysis Research and Innovation ... a Freeslate Core Module 3 (CM3) Reaction Screening ... to accelerate current research programs. The systems will be ... be available to academic users and industrial collaborators/ partners ...
(Date:4/21/2015)... RI (PRWEB) April 21, 2015 Spring ... trips, with many people visiting family for the holidays ... household pets while planning to travel can be a ... choosing to travel with pets is becoming a more ... tips for making a stay at pet-friendly accommodations a ...
(Date:4/21/2015)... This program provides physical therapists, ... occupational therapist assistants, teachers, and other school based ... children across the autism spectrum succeed in the ... Inc. , Used throughout the United ... yoga curriculum addresses learning and behavior issues across ...
Breaking Medicine News(10 mins):Health News:US Sports Camps and The Northeast Football Clinic Announce 2015 Lineman/Linebacker Clinic Schedule 2Health News:Beverly Hills Plastic Surgery Expert Dr. Zain Kadri Releases Thought-Provoking New Infographic 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 3Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 2Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 3Health News:Royal Flush Havanese Announces 5 Tips for a Successful Stay in Pet-Friendly Accommodations 4Health News:ABC News Interviews Anne Buckley-Reen, Education Resources Inc. Faculty Member, on Yoga Therapy in the Classroom 2
... delusional was removed and the name was shortened as Calgaria. ... the content and presentation// continue to insult those afflicted by ... to be light-hearted about this, but those of us living ... it quite insulting,” said Roy Muir, who suffers from depression ...
... study finds that stents do not prevent heart attacks ... chest pains and to prevent heart attacks//. Stents are ... them open. ,This landmark study funded by ... do improve blood flow but are no more effective ...
... to AAWL in adults between the ages of 18 ... ,Arthritis, a leading cause of disability among ... (AAWL) can have substantial social and economic impacts including ... ,This study was published in the April ...
... Kickboxing can cause damage to the pituitary gland, a pea-sized ... the bridge of the nose//, scientists say. ,The ... things, the body's regulation of metabolism coping with daily stress, ... team at Erciyes University Medical School in Turkey measured the ...
... that people whose diets contain dramatically more of one ... at greater risk// for both clinical depression and certain ... week in the journal Psychosomatic Medicine, suggests that we ... omega-3 fatty acids. The current typical American diet contains ...
... pain, an important component of diagnosis, are now revealed to ... previously thought.// ,Spatial aspects of pain are a ... on the study and a neuroscientist at Wake Forest University ... and pain from a heart attack, for example. Pain from ...
Cached Medicine News:Health News:Stents Do Little to Prevent Heart Attacks 2Health News:AAWL Affects Quality of Life 2Health News:AAWL Affects Quality of Life 3Health News:Omega-3 Fatty Acids Affect Risk of Depression, Inflammation 2Health News:Omega-3 Fatty Acids Affect Risk of Depression, Inflammation 3Health News:Multiple Regions of the Brain Locate Pain 2
(Date:4/20/2015)... April 20, 2015  Teradata (NYSE: TDC ... marketing applications company, today announced the ... Analytics Framework for Life Sciences helps organizations integrate ... and Early Discovery (RED), clinical analysis, Real-World Evidence ... relevant sources, companies can benefit by bringing safer, ...
(Date:4/20/2015)... WASHINGTON , April 20, 2015 Pharmaceutical ... an estimated $51.2 billion last year in the research ... The figure represents the majority of all biopharmaceutical R&D ... the United States . The new R&D ... member companies, are highlighted in the newly released ...
(Date:4/20/2015)... Ill. , April 20, 2015  U.S. pharmacy cost ... expected to drift into the low double-digits by 2016, according ... talent, retirement and health solutions business of Aon plc ... design changes are projected to be 9.5 percent in 2015 ... Aon Hewitt predicts a similar rate of increase ...
Breaking Medicine Technology:Teradata Delivers Big Analytics Innovation for Life Sciences 2Teradata Delivers Big Analytics Innovation for Life Sciences 3Teradata Delivers Big Analytics Innovation for Life Sciences 4PhRMA Member Companies Invested $51.2 Billion in R&D in 2014 2PhRMA Member Companies Invested $51.2 Billion in R&D in 2014 3Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 2Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 3Aon Analysis Shows Double-Digit Increases in U.S. Pharmacy Costs by 2016 4
... Macular ... ... privately held ophthalmic pharmaceutical company, announced today that,enrollment has been completed ... of its lead product, IBI-20089, in patients with,cystoid macular edema. This ...
... ... combination therapy High SVR 24 rate ... Schering-Plough,Corporation (NYSE: SGP ) today reported top-line results from a planned,interim ... protease inhibitor. The analysis showed a high rate of,sustained virologic response (SVR) ...
Cached Medicine Technology:Icon Bioscience Completes Enrollment in Phase I Study of Novel Ophthalmic Drug Candidate 2Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 2Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 3Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 4Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 5Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 6Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 7Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 8Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 9
... One of the smallest handheld oximeters ... spot-check solution for hospital, home care, transport, ... standard features., ,PIr (relative perfusion index ... for a dynamic numeric reflection of perfusion ...
... power of clinical information. , ,S/5 ... clinical connectivity solutions that help you and ... patient care. You will have access to ... share it with your care team and ...
... value for size., ,The Datex-Ohmeda S/5 Light ... use in anesthesia and critical care areas, in ... inter-hospital transport. As part of the Datex-Ohmeda S/5 ... intuitive user interface and design shared by all ...
... the operating and recovery room, ,The ... combined haemodynamic and airway gas monitoring for ... care units. The Cardiocap II is available ... basic haemodynamic measurements. Two of the models ...
Medicine Products: