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Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
Date:11/24/2008

Johns Hopkins researchers have discovered that a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes. The drugs helpfully accelerate loss of fluids, but also deplete important chemicals, including potassium, so that those who take them are generally advised to eat bananas and other potassium-rich foods to counteract the effect.

"Previous studies have told us that when patients take diuretic thiazides, potassium levels drop and the risk of diabetes climbs to 50 percent," says lead researcher Tariq Shafi, M.D., M.H.S., of the Department of Nephrology at Johns Hopkins University School of Medicine. "Now, for the first time, we think we have concrete information connecting the dots."

Thiazides, such as chlorthalidone, are an inexpensive and highly effective way to treat high blood pressure and have been used widely for decades. However, their association with diabetes has forced many hypertension suffers to use other medications that can be several times as expensive, says Shafi.

"This study shows us that as long as physicians monitor and regulate potassium levels, thiazides could be used safely, saving patients thousands of dollars a year," says Shafi. "It could be as simple as increasing the consumption of potassium-rich foods like bananas and oranges and/or reducing salt intake, both of which will keep potassium from dropping."

Researchers examined data from 3,790 nondiabetic participants in the Systolic Hypertension in Elderly Program (SHEP). SHEP is a randomized clinical trial conducted between 1985 and 1991 designed to determine the risk versus benefit of giving a certain high blood pressure medication to people age 60 years or older.

Half of the subjects were treated with chlorthalidone and half with a fake drug. Of the 3,790 subjects, 1,603 were men and 724 were nonwhite. None ha
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Contact: Eric Vohr
evohr1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
Source:Eurekalert

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