Navigation Links
Pot Plus Alcohol Kills Young Rats' Brain Cells

Finding another warning to pregnant women that drug use can affect fetal brain development

TUESDAY, April 22 (HealthDay News) -- A combination of THC, the main psychoactive ingredient in marijuana, and mildly intoxicating doses of alcohol caused widespread nerve cell death in the brains of young rats, a German study finds.

Researchers from Humboldt University, Berlin, administered THC, a synthetic form of THC, ethanol, an anticonvulsant called MK-801, and phenobarbital to rats between one and 14 days old. A previous study by the same team found that ethanol and drugs such as sedatives, anesthetics and anticonvulsants caused extensive nerve cell death in the brains of young rodents. The new study was conducted to determine if cannabinoids caused similar harm.

The researchers found that THC and synthetic THC did not cause nerve cell death when administered alone but did cause cell death when given with mildly intoxicating amounts of ethanol. The combined effect increased according to the dose of THC and was strongest when the rats were seven days old.

The researchers also found that the CB1 receptor blocker drug Rimonabant reduced brain nerve cell death in rats given a combination of THC and ethanol. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. The fact that the drug counteracted the effect of THC and ethanol suggests that activation of CB1 receptors may be responsible for the effect that THC has on the neurotoxicity of ethanol, the researchers said.

The study was published in the journal Annals of Neurology.

More studies are needed to examine how THC boosts alcohol's harmful effects on the developing brain, the researchers said.

"With the use of behavioral and stereological techniques, such studies would explore whether acute changes reflect permanent neuronal loss and lead to behavioral deficits," they concluded. "The results of the acute studies have interesting potential therapeutic implications for including the use of CB1 receptor antagonists for preventing brain damage in fetuses and neonates exposed to ethanol, sedative and/or anticonvulsant drugs."

The German group noted that marijuana is among the most commonly used illicit drugs by women during their childbearing years. There's growing concern that use of marijuana, either alone or in combination with other drugs, during pregnancy may harm fetal brain development.

More information

The March of Dimes has more about the dangers of drinking during pregnancy.

-- Robert Preidt

SOURCE: Annals of Neurology, news release, April 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Alcohol Awareness Month: Distilled Spirits Council Urges Government Support for Standard Drink Information on Labels
2. Focus on Children of Alcoholics at Addiction Agencys Annual Meeting
3. Triple threat: Young macho men with serious injuries often abuse alcohol
4. Marijuana increases alcohol toxicity in young rats
5. Emergency Departments Nationwide Institute New Alcohol Screening and Intervention Process
6. Alcoholics Not to Blame for All Drunk Driving Cases
7. Do we need alcohol prevention programs for tweens?
8. Brain DNA remodeled in alcoholism
9. Hospitality tops list of industries with highest rates of alcohol problems
10. Some moms quit cigarettes, marijuana, alcohol during pregnancy, but dads dont
11. Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... ... Water For Empowerment ™ attracts volunteers together who want to combine talents ... women as key stakeholders in the process. The non-profit launched its first major ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the traditional ... models of traditional and far-infrared saunas. , For traditional saunas, Finnleo is ... traditional Finnish sauna wood, and Finnleo uses only European Grade A Nordic White Spruce ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... offering factory direct sauna parts and accessories. , Sauna accessories help improve ... the bather’s style and personality. From basic styles for the purist looking for ...
(Date:11/25/2015)... , ... November 26, 2015 , ... ... Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public ... in Nairobi (UNON) for the opening of the 5th African Network for Drugs ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... 26, 2015 ... adds "Global Repaglinide Industry 2015 ... on China Repaglinide Market, 2010-2019" reports ... and information to its online business ... . --> ...
(Date:11/25/2015)... 25, 2015 ... the "Global Brain Monitoring Devices Market ... --> ) has announced the ... Devices Market 2015-2019" report to their ... ( ) has announced the addition ...
Breaking Medicine Technology: