Navigation Links
Post-Op Chemo Fails to Boost Survival in Stomach Cancers

Drug-surgery combo showed no significant improvement in outcomes, study finds

TUESDAY, March 11 (HealthDay News) -- Chemotherapy following surgery does not improve survival in stomach cancer patients, says an Italian study.

Currently, surgery is the only treatment that can potentially cure non-metastatic gastric cancer, according to background information in the study. However, some recent research has suggested that a chemotherapy combination of cisplatin, epirubicin, 5-fluorouracil and leucovorin (PELF) improves outcomes in people with metastatic gastric cancer.

In this study, researchers tested the PELF combination in patients with localized gastric cancer. Some of the 258 patients in the study were treated with surgery only, while others had surgery followed by chemotherapy.

At a median follow-up of 72.8 months, there was no statistical difference between the two groups in terms of disease-free survival or overall survival. Disease progression occurred in 47.7 percent of patients in the surgery/chemotherapy group and in 51.6 percent of those in the surgery group.

The survival rate was 47 percent in the surgery/chemotherapy group and 45.3 percent in the surgery group.

The study was published in the March 11 online issue of the Journal of the National Cancer Institute.

"Our study confirms that a dose-intense regimen like PELF, which showed very promising results in advanced gastric cancer, is not effective in an adjuvant setting," wrote the researchers from the University Hospital Careggi in Florence and the Italian Oncology Group for Cancer Research. Based on these and other recent negative findings, the authors concluded: "Adjuvant chemotherapy alone remains a controversial approach in operable gastric cancer."

In an accompanying editorial, two doctors at the Beijing Cancer Hospital and Institute in China discuss conflicting findings from recent trials examining the use of chemotherapy and radiation to treat patients with localized gastric cancer.

Even though overall data is inconsistent, chemotherapy, radiation or a combination of the two should be used in patients with localized gastric cancer, said Dr. Aiwen Wu and Dr. Jiafu Ji.

"Surgery alone is no longer the standard treatment for patients with resectable gastric cancer, independent of the patient population or the practice location," they wrote.

More information

The American Cancer Society has more about stomach cancer.

-- Robert Preidt

SOURCE: Journal of the National Cancer Institute, news release, March 11, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Tied to Post-Op Delirium in Elderly
2. UI nursing researcher to study post-operative pain control
3. Flynn Pharma Acquires Rights From Pacira Pharmaceuticals to DepoDur(R), the Only Extended-Release Epidural Opioid for Post-Operative Pain, in Europe
4. Acupuncture Cuts Need for Post-Op Painkillers
5. Chewing gum -- the new post-operative medicine
6. Chemotherapy may be culprit for fatigue in breast cancer survivors
7. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
8. To evade chemotherapy, some cancer cells mimic stem cells
9. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
10. PET scans can accurately detect a breast tumors response to chemotherapy
11. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
Post Your Comments:
Related Image:
Post-Op Chemo Fails to Boost Survival in Stomach Cancers
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at which ... age, more care is needed, especially with Alzheimer’s, dementia and other cognitive conditions ... overworked. The forgotten part of this equation: 80 percent of medical care occurs ...
(Date:11/27/2015)... County, CA (PRWEB) , ... November 27, 2015 , ... ... season , The company is offering customers 10% off of their purchase of lice ... any treatment at full price. According to a company spokesperson. “Finding lice is a ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... motto of progress through sharing, the 2016 Building Better Radiology Marketing Programs ... conference will begin on Sunday, March 6, 2016, at Caesars Palace in Las ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping ... platform for mental health and wellness consultation, has collaborated with a leading web-based ... the knowledge gap experienced by parents and bring advice from parenting experts within ...
(Date:11/27/2015)... , ... November 27, 2015 , ... Avid collector, Andrew ... Arbor Michigan boxing style concert posters. This is one of Joplin's most famous and ... House at the University of Michigan in Ann Arbor. The According to Hawley, "It ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new ... Japanese therapeutic drug monitoring market, including emerging tests, ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... Wound Care Market by Type (Dressings, Therapy Devices, Active ... Facility, Out-Patient Facility), and Geography - Global Forecast to ... --> --> The purpose of ... forecast of the global advanced wound care market. It ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "Radioimmunoassay Market ... User (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic ... - Global Forecast to 2020" report ... ) has announced the addition of the ...
Breaking Medicine Technology: