Navigation Links
Post-Op Chemo Fails to Boost Survival in Stomach Cancers

Drug-surgery combo showed no significant improvement in outcomes, study finds

TUESDAY, March 11 (HealthDay News) -- Chemotherapy following surgery does not improve survival in stomach cancer patients, says an Italian study.

Currently, surgery is the only treatment that can potentially cure non-metastatic gastric cancer, according to background information in the study. However, some recent research has suggested that a chemotherapy combination of cisplatin, epirubicin, 5-fluorouracil and leucovorin (PELF) improves outcomes in people with metastatic gastric cancer.

In this study, researchers tested the PELF combination in patients with localized gastric cancer. Some of the 258 patients in the study were treated with surgery only, while others had surgery followed by chemotherapy.

At a median follow-up of 72.8 months, there was no statistical difference between the two groups in terms of disease-free survival or overall survival. Disease progression occurred in 47.7 percent of patients in the surgery/chemotherapy group and in 51.6 percent of those in the surgery group.

The survival rate was 47 percent in the surgery/chemotherapy group and 45.3 percent in the surgery group.

The study was published in the March 11 online issue of the Journal of the National Cancer Institute.

"Our study confirms that a dose-intense regimen like PELF, which showed very promising results in advanced gastric cancer, is not effective in an adjuvant setting," wrote the researchers from the University Hospital Careggi in Florence and the Italian Oncology Group for Cancer Research. Based on these and other recent negative findings, the authors concluded: "Adjuvant chemotherapy alone remains a controversial approach in operable gastric cancer."

In an accompanying editorial, two doctors at the Beijing Cancer Hospital and Institute in China discuss conflicting findings from recent trials examining the use of chemotherapy and radiation to treat patients with localized gastric cancer.

Even though overall data is inconsistent, chemotherapy, radiation or a combination of the two should be used in patients with localized gastric cancer, said Dr. Aiwen Wu and Dr. Jiafu Ji.

"Surgery alone is no longer the standard treatment for patients with resectable gastric cancer, independent of the patient population or the practice location," they wrote.

More information

The American Cancer Society has more about stomach cancer.

-- Robert Preidt

SOURCE: Journal of the National Cancer Institute, news release, March 11, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Tied to Post-Op Delirium in Elderly
2. UI nursing researcher to study post-operative pain control
3. Flynn Pharma Acquires Rights From Pacira Pharmaceuticals to DepoDur(R), the Only Extended-Release Epidural Opioid for Post-Operative Pain, in Europe
4. Acupuncture Cuts Need for Post-Op Painkillers
5. Chewing gum -- the new post-operative medicine
6. Chemotherapy may be culprit for fatigue in breast cancer survivors
7. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
8. To evade chemotherapy, some cancer cells mimic stem cells
9. New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas
10. PET scans can accurately detect a breast tumors response to chemotherapy
11. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
Post Your Comments:
Related Image:
Post-Op Chemo Fails to Boost Survival in Stomach Cancers
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
Breaking Medicine Technology: