Navigation Links
Possible treatment for serious blood cancer
Date:5/6/2013

A single antibody could be the key to treating multiple myeloma, or cancer of the blood, currently without cure or long-term treatment.

"We tested the antibody in various ways, including on tumour cells from myeloma patients that have been transplanted into mice. The tests showed that the antibody is able to destroy myeloma cells", explains Markus Hansson, a researcher at Lund University in Sweden.

Using a 'biological library' of thousands of antibodies from the company BioInvent in Lund, the team singled out antibody BI-505, shown to have a powerful effect on the tumour cells in both cell studies and animal experiments. It has also been tested in an initial safety study on seriously ill patients, and a study of its treatment effects has just started.

"This study will include patients who have just been diagnosed and therefore still feel fairly well. We want to test the antibody treatment before the patients are treated with any other drugs", says Markus Hansson.

Today there are a number of drugs to treat multiple myeloma, but no cure. None of the drugs are able to eradicate the disease, meaning cancer cells increase in number after a period of remission. Survival has been extended with new treatments, but less than half of all patients live longer than five years from diagnosis.

Myeloma occurs when a specific type of cell in the bone marrow is converted into tumour cells. Blood formation is disrupted and patients suffer from a lack of blood resulting in fatigue. The bones can be weakened with a risk of fractures and compacted vertebrae, and patients sometimes suffer kidney failure as a result of the disease.

Antibodies are a part of the immune system, fighting off foreign bodies. Antibody-based drugs are now used to treat certain inflammatory diseases and types of cancer.

The treatment study in Lund will involve 15 patients and is expected to be completed this year. If the results are good, Markus Hansson and his colleagues hope to be able to continue testing BI-505 in larger-scale studies. They will be studying the best way of using the new antibody: alone or in combination with other drugs; at the start of the disease or at a later stage.


'/>"/>

Contact: Markus Hansson
markus.hansson@med.lu.se
46-705-931-110
Lund University
Source:Eurekalert

Related medicine news :

1. Zamansky & Associates LLC Investigates Chemed Corporation For Possible Securities Law Violations And Breaches Of Fiduciary Duties To Shareholders
2. US Drug Watchdog Is Expanding Their Transvaginal Mesh Failure Initiative And They Are Urging Victims To Call Them For The Names Of The Best Possible Women Lawyers To Help
3. Lung Cancer Asbestos Victims Center Now Urges Any Type Of Lung Cancer Victim Who Was Exposed To Asbestos At Work To Call Them About Possible Significant Compensation
4. Personal Injury Lawyer Sean M. Cleary Warns Resort Vacationers about Possible Accidents and Injuries
5. Lung Cancer Asbestos Victims Center Now Urges All Lung Cancer Victims To Call Them If They Were Exposed To Asbestos In Their Place Of Work-Possible Major Compensation
6. Pancreatic Cancer Correlation to Type 2 Diabetes Drugs Januvia and Byetta, New Studies Find Possible Connection
7. Lung Cancer Asbestos Victims Center Now Urges All US Citizens With Any Type Of Lung Cancer To Call Them About Possible Compensation-Were You Exposed To Asbestos
8. Lung Cancer Asbestos Victims Center Now Urges Lung Cancer Victims Who Are Nonsmokers And Were Exposed To Asbestos On The Job To Call Them-Possible Major Compensation
9. Battle for Grace: A Memoir of Pain, Redemption and Impossible Love
10. US Drug Watchdog Now Urges Transvaginal Mesh Failure Victims With A Failed Revision Surgery to Call Them for the Names of the Best Possible Women Attorneys
11. Lung Cancer Asbestos Victims Center Now Urges Nonsmoker Lung Cancer Victims Who Were exposed To Asbestos In Their Workplace To Call Them About Possible Compensation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... 2017 , ... An August 2 article on NextShark discusses a ... influenced by the growing popularity of “pretty boys” in both K-Pop and television K-Drama. ... male appearance are changing not only in the Asian nation, where plastic surgery has ...
(Date:8/17/2017)... ... 2017 , ... Pot Valet is a leading provider of premium medical-grade cannabis ... state, and soon, every state in the country, the company offers patients safe, legal, ... altogether. , According to Pot Valet, all California patients have the legal ...
(Date:8/17/2017)... ... August 17, 2017 , ... A recent report indicates that ... industry in 2016 cited deficiencies in data integrity. The FDA outlines their expectations for ... , Presented as part of the Beckman Coulter Life Sciences Virtual Trade ...
(Date:8/16/2017)... ... August 16, 2017 , ... An August 3rd article on Reuters covers ... of a report in JAMA (the Journal of the American Medical Association). The study found ... to achieve BMIs under 30, when compared to patients with lower BMIs. At present, weight ...
(Date:8/16/2017)... , ... August 16, 2017 , ... ... is collaborating with a New England student to educate the public on the ... in 2016 for launching the first-ever National Concussion Awareness Day. , Brooke is ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, Belmar ... The reputable clinic will continue to be co-owned and managed ... of four clinicians. Lipkin received his doctorate in physical therapy ... of experience with a strong background in manual therapy. ... clinic in and around the Denver ...
(Date:8/7/2017)... WARSAW, Ind. , Aug. 7, 2017 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the third quarter of 2017. ... will be paid on or about October 27, 2017 to ... September 22, 2017.  Future declarations of dividends are subject to ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
Breaking Medicine Technology: