Navigation Links
Possible safer target for anti-clotting drugs found
Date:9/26/2007

Researchers at the University of Illinois at Chicago College of Medicine have identified a new molecular target in blood clot formation, which seems to reduce clotting without excessive bleeding, the common side-effect of anti-clotting agents.

The findings are reported in the September issue of Molecular and Cellular Biology.

"It was very surprising to find an enzyme whose inhibition lessened platelet aggregation without abnormal bleeding, and we immediately realized that it could have very important implications for the treatment of cardiovascular disease," said Shafi Kuchay, a graduate student in pharmacology and first author of the paper.

When clots form, small blood cells called platelets begin to clump together. Aspirin and other anti-clotting agents reduce the risk of heart attack and stroke by blocking the biochemical pathway that causes platelets to become sticky. But all these drugs put patients at risk of excessive bleeding.

The UIC researchers made a mouse model that lacked a gene for a protease enzyme most commonly found in blood cells called calpain-1, in order to determine its function. They found that mice lacking calpain-1 had reduced platelet aggregation but did not have any abnormal bleeding.

The mice lacking calpain-1 (called "knockout" mice) had increased levels of another enzyme, known as protein tyrosine phosphatase-1B. When the mice were given a PTP1B inhibitor, the reduced platelet aggregation was restored. When calpain-1 knockout mice and mice lacking PTP1B were crossed to create double-knockout mice, platelet aggregation was restored in the offspring that lacked the genes for both enzymes. The researchers were thus able to establish that PTP1B turns off the signal for platelet aggregation and that calpain-1 regulated the amount and activity of this "off switch."

"Because of the danger of excessive bleeding, people taking anti-clotting medications are monitored carefully and warne
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
2. Early diagnosis for autism from blood tests may be possible
3. Borderline blood pressure- possible health risk
4. Depression a possible danger in elderly
5. Possible benefits of Hormone Replacement Therapy
6. Use of zinc supplements tied to possible increase in risk of prostate cancer
7. Return of SARS possible this fall
8. Low Protein Levels A Possible Indicator For A Miscarriage
9. Cure For Persistent Oral Fungal Problem May Be Possible
10. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
11. New treatment possible for drug addiction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... not same, as study cites obesity as possible cause , , ... development of insulin resistance in older men, but not women, ... diabetes, occurs when the body cannot use insulin properly. As ... obese people are prone to insulin resistance, because excess fat ...
... fusion cuisine is one of,the year,s hottest trends(1). ... international flavors are filling Americans, plates. And because,it ... flavor profiles,it,s no surprise that pork is consumed ... the creators of The Other White Meat(R) campaign ...
... the largest online retailers of diabetic testing supplies launched an ... for people with diabetes , , ... even stronger support system thanks to Diabetic Care Services, one ... The company launched an improved version of its Web site ...
... DIEGO, Dec. 5 Cardium Therapeutics,(NYSE Alternext: CXM) ... New York City,s adoption of procedures designed to ... featured in an,article in The New York ... Therapy,",dated December 4, 2008, reports that New York ...
... #236 , , BETHLEHEM, Pa., ... products and practices , B. Braun Medical Inc. (B. Braun) ... American Society of Health-System Pharmacists Midyear Clinical Meeting and Exhibition ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ...
... problems, study says , , FRIDAY, Dec. 5 (HealthDay News) -- ... are three times more likely than people without the disease ... according to a British study. , "If you look ... threefold increased risk of acute coronary syndrome, which is a ...
Cached Medicine News:Health News:Vitamin K Slows Insulin Resistance in Older Men 2Health News:Take Taste Buds on a Trip Around the World This Holiday Season 2Health News:Take Taste Buds on a Trip Around the World This Holiday Season 3Health News:Turn to Diabetic Care Services for Personalized Support and Hassle-Free Diabetes Supplies 2Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 2Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 3Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 4Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 5Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 6Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 7Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 8Health News:Cardium Reports on New York City's Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients 9Health News:Be Green with B. Braun: Company Shares Expertise, Environmentally Responsible Products at ASHP 2008 2Health News:Be Green with B. Braun: Company Shares Expertise, Environmentally Responsible Products at ASHP 2008 3Health News:Lung Disease Tied to Increased Risk for Cardiac Events 2
(Date:12/24/2014)... , Dec. 24, 2014  Diplomat Pharmacy, Inc. ... specialty pharmacy, is proud to announce Jennifer Hagerman ... at Diplomat, will take office as the president of ... formal induction ceremony will take place Feb. 28, 2015, ... be held at the Renaissance Center in ...
(Date:12/24/2014)... , Dec. 23, 2014  Advanced Medical Isotope ... engaged primarily in the development of brachytherapy devices ... today announced that it has filed a ... Drug Administration ("FDA") for marketing clearance for its ... of the U.S. Food, Drug and Cosmetic Act ...
(Date:12/24/2014)... Dec. 23, 2014  Lockton Dunning Benefits, the ... Companies, announced the addition of Vice President ... Lockton Dunning,s Pharmacy Consulting team, Excelsior Solutions. ... industry experience to the position.  Most recently, she ... at Diplomat Specialty Pharmacy, where she has held ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Kim Foerster Joins Lockton Companies 2
... This BioSafe room is configured specifically ... and chemical analysis. Panels are precision-joined ... easy to wipe down and disinfect. ... double-wall panel design creates strong, rigid ...
... Features hardwall acrylic panels ... frame to form a free-standing ... to Class 10/ISO 3. Optional ... and ionizers are configured to ...
... curtains or parting strip shields ... frame to form a free-standing, ... cleanliness to Class 10/ISO 3. ... lights, and ionizers are configured ...
... cleanroom for biological safety labs (BSL) ... (to Class 10/ISO 3) and easy ... ultra-smooth surfaces that are easy to ... corners simplify cleaning. Unique double-wall panel ...
Medicine Products: