Navigation Links
Possible pharmacological target(s) identified in pediatric OSA
Date:2/4/2010

pertinent genes, those with the most connectivity," explained Dr. Gozal. "We identified 47 genes and among those, two specific genes, both phosphatases, which are known to be very important at regulating communication in cells. Then we looked at the expression of the phosphatase protein and found that children with OSA have higher level of phosphatases in the tonsils." In particular, they focused on one protein called phosphoserine phosphatase (PSPH) that was expressed in children with OSA, but almost never expressed in the children with RI.

"We asked, 'What happens if we block this phosphatase?'" said Dr. Gozal. "Is this a potential target for pharmacological therapy?" Indeed, they found that introducing calyculin, a phosphatase inhibitor, reduced the cell proliferation and increased programmed cell death, or apoptosis, a process by which cells self-regulate, in the tonsils of OSA patients. "Together, these observations suggest that PSPH is a logical therapeutic target in reversing adenotonsillar enlargement in pediatric OSA," Dr. Gozal wrote.

"The next direction is to identify if selective clones of proliferating cells that may be affected by PSPH or by another of the discovered target genes with the intent of developing a non-surgical alternative treatment to surgery for OSA in children," said Dr. Gozal. "If there is a subgroup of cells that have specific markers, then we may be able to develop a therapy that could be specifically targeted to these cells."

"Phosphatases such as PSPH are an exciting prospective target for therapy in children with OSA," said Dr. Gozal. "We believe if we had effective non-surgical alternatives to tonsillectomies, it would be of great benefit."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH takes step to assess any possible risk associated with low-dose radiation exposure
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Rush Limbaugh & Michael Steele Join Tea Party Support & Social Security Institute-Demand GOP Senate Stop ObamaCare by Any Means Possible
4. Possible ovarian cancer treatment target identified
5. Urine test for pediatric obstructive sleep apnea possible
6. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
7. Researchers Identify Possible Causative Mutation for Crohn's Disease: Crohn's & Colitis Foundation Annual Conference to Present Emerging Research
8. Experts Examine Possible Links Between Climate Change and Infectious Disease Transmission
9. Less HRT, Fewer Cases of Possible Breast Cancer Precursor
10. Firm Says Low-Cost Genome Sequencing Is Possible
11. Expert predicts possible shift in senior voting bloc
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... Linda Kincaid, age 67, knew something was wrong. She constantly ... thought it was just a part of getting older, but ... After going to the doctor, she received a distressing diagnosis: ... might happen to her. , Linda is not alone. As ... each year. Valve disease involves damage to one or more ...
(Date:6/1/2015)... Portland, Ore. (PRWEB) June 01, 2015 ... Plans (AHIP) announced today a new, interactive Affordable ... support large employers. The course, called “Affordable Care ... care professionals with the strategic and consultative insights ... employers as they navigate the impacts of the ...
(Date:6/1/2015)... NY (PRWEB) June 01, 2015 For ... patients requesting celebrity features. Much like one would request ... stars’ noses, eyes, cheeks, chin and more to illustrate ... filtering apps like FaceTune are ushering in a new ... Manhattan facial plastic surgeon, Sam Rizk, MD, FACS notes ...
(Date:6/1/2015)... June 01, 2015 Listen to Volvo’s ... automotive companies are using more granular data to create ... comparatively new industry voices in Josep Celaya Gonzalez, CIO ... start-up ParkTAG. As an automotive insurer, MAPFRE are well ... an easy-to-use solution to the driver. Award winning start-up ...
(Date:6/1/2015)... 2015 A University of Texas ... signaling proteins that activate protein degradation, which helps ... 1 , The study published April 3rd ... Spraque-Dawley rats 2-3 months of age who performed ... given either whey protein (.4g/kg), low-dose Sustamine (.1g/kg), ...
Breaking Medicine News(10 mins):Health News:A New Online Resource for Those Living with Heart Valve Disease 2Health News:A New Online Resource for Those Living with Heart Valve Disease 3Health News:Cambia Partners with AHIP to Offer Expert Series ACA Training Course 2Health News:Cambia Partners with AHIP to Offer Expert Series ACA Training Course 3Health News:Instagram Filters Launch New Facial Plastic Surgery Trend 2Health News:Complimentary Webinar: Volvo, MAPFRE and Award Winning Start-Up discuss new Frontier of In-Car Services 2Health News:Study Shows Taking Sustamine® L-Alanyl-L-Glutamine May Reduce Muscle Protein Breakdown After Resistance Exercise 2Health News:Study Shows Taking Sustamine® L-Alanyl-L-Glutamine May Reduce Muscle Protein Breakdown After Resistance Exercise 3
... of poor children with congenital heart diseases (CHD) here moved ... the US by a non-profit organization. About 40-50 NRIs have ... keen to sponsor a child or two every year ... born in India with CHD. Only six to eight percent ...
... devised a new system that ranks foods according to ... and developed// by a panel of independent nutritionists, dietitians, ... as well as members of the government’s Scientific Advisory ... developed by the UK’s Food Standards Agency (FSA) has ...
... change in the genetic constitution is what makes each ... is unraveled, then health care can be individualized according ... same genetic code, how those genes express themselves at ... medicines and dietary advice. According to a recent study, ...
... among couples who smoke according to a new study// which ... stroke than cigarette-smoking women with non-smoking spouses. ,The study ... total stroke and ischemic stroke (a stroke caused by a ... groups of women. The relative risk of total stroke was ...
... fine combing of wet hair may be far more ... ,Researchers have used single blind randomized controlled trial ... counter insecticide treatments against head lice in United Kingdom. ... more effective than current over the counter chemical treatments ...
... with severe asthma according to a recent study.// This ... of antioxidants such as vitamin C and incidence of ... intakes and blood concentrations of antioxidants, including vitamin C, ... without asthma. , ,Men with severe asthma had ...
Cached Medicine News:Health News:Nutrient Profiling System Launched By Food Officials in UK 2Health News:Learning Just How Different We Are 2Health News:Combing Hair More Effective Than OTC Medicine For Head Lice 2
(Date:6/1/2015)... Novel t reatments   entering the ... GBI Research . ... driven primarily by the introduction of numerous premium therapies, particularly ... or combine with generic chemotherapies. Analysis from business ... Market to 2020 - forecasts the value of the ...
(Date:6/1/2015)... , June 1, 2015 Symbiotix Biotherapies, ... $2.3 million Phase 2 Small Business Technology Transfer (STTR) ... National Institute of Allergy and Infectious Diseases (NIAID). The ... developing a novel class of molecular therapeutics from ... clinical candidate, Polysaccharide A (PSA), is the first molecule ...
(Date:6/1/2015)... June 1, 2015   OTC Markets Group ... and Connected financial marketplaces for 10,000 U.S. and ... San Diego -based biopharmaceutical company, on ... America,s only public venture market for entrepreneurial and ... http://photos.prnewswire.com/prnh/20110118/MM31963LOGO "We,re happy to ...
Breaking Medicine Technology:New Therapies to Enhance Increasingly Competitive Non-Small Cell Lung Cancer Treatment Market 2New Therapies to Enhance Increasingly Competitive Non-Small Cell Lung Cancer Treatment Market 3Symbiotix Biotherapies Announces $2.3 Million Award from NIH's National Institute of Allergy and Infectious Diseases (NIAID) 2OTC Markets Group Congratulates OncoSec Medical on NASDAQ Listing 2
... /PRNewswire-Asia/ -- Bristol-Myers Squibb Company (NYSE: ... (NYSE: SCR ), a leading pharmaceutical company ... the strategic partnership formed last year to include a ... agreed to co-develop BMS-795311, Bristol-Myers Squibb,s preclinical small molecule ...
... SAN DIEGO, Dec. 13, 2011  BioMed Realty Trust, Inc. ... has entered into a definitive agreement to acquire Prudential ... Street properties.  BioMed previously acquired a 20% interest in ... venture entered into between BioMed and PREI.  The Rogers ...
Cached Medicine Technology:Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 2Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 3Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Cardiovascular Compound 4Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 2Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 3Biomed Realty Trust to Acquire Remaining 80% Interest in Rogers Street Properties in Cambridge, Massachusetts for $308 Million - Increasing Ownership to 100% 4
Coibri handle. Pierse tips with 6 mm platform. 2.5 mm angled tips. Manufactured in titanium....
Straight shafts with 2.0 mm, 1 x 2 Elschnig style teeth. Serrated handle with polished finish. Handle: Wide....
Straight shafts with 45 degrees, 0.12 mm, 2 x 3 teeth and tying platform. Serrated handle with polished finish....
Straight shafts with 0.1 mm Pierse tips. Flat smooth handle with dull finish....
Medicine Products: