Navigation Links
Possible pharmacological target(s) identified in pediatric OSA
Date:2/4/2010

Children with obstructive sleep apnea (OSA) may one day be able to have an injection or use a throat spray instead of getting their tonsils removed to cure their snoring, according to a new study from the University of Chicago, which found that a specific gene product may be responsible for the proliferation of adenotonsillar tissue that can cause pediatric OSA.

"We found that in the tonsil tissues of children with OSA, certain genes and gene networks were over expressed," said David Gozal, M.D., professor and chair of the Department of Pediatrics, who led the study. "We believe that the results of this gene overexpression is increased proliferation of the adenotonsillar tissues, which in turn can cause partial or complete obstruction of the upper airways during sleep."

The findings have been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the United States, two to three percent of children have OSA. The current standard of treatment is surgical removal on the tonsils, but surgery is not without risks and potential complications. Currently, about 600,000 tonsillectomies are performed each year in children, primarily to treat OSA.

Dr. Gozal and colleagues have been studying potential non-surgical alternatives to treat OSA in children. To identify potential pharmacological targets, they recruited 18 children with OSA and 18 age-, gender-, and ethnicity-matched children with recurrent tonsillar infections (RI), all of who underwent surgery to have their tonsils removed.

The tonsil tissue from each subject was analyzed for relative expression of the 44,000 known genes in the human genome. The researchers then further analyzed the gene pathways to determine which changes may represent differences with a high likelihood of impact on cellular proliferation.

"We wanted to find the most important and functionally
'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NIH takes step to assess any possible risk associated with low-dose radiation exposure
2. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
3. Rush Limbaugh & Michael Steele Join Tea Party Support & Social Security Institute-Demand GOP Senate Stop ObamaCare by Any Means Possible
4. Possible ovarian cancer treatment target identified
5. Urine test for pediatric obstructive sleep apnea possible
6. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
7. Researchers Identify Possible Causative Mutation for Crohn's Disease: Crohn's & Colitis Foundation Annual Conference to Present Emerging Research
8. Experts Examine Possible Links Between Climate Change and Infectious Disease Transmission
9. Less HRT, Fewer Cases of Possible Breast Cancer Precursor
10. Firm Says Low-Cost Genome Sequencing Is Possible
11. Expert predicts possible shift in senior voting bloc
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New York’s only Thermage skin ... the first provider of Exilis non-surgical fat reduction in New York. Due to ... a large International clientele. Many patients travel to New York to get their ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2nd annual Ride to Fight ... Memphis on October 3, 2015. The Ride to Fight On is a cycling fundraiser ... Methodist Healthcare, The West Clinic and The University of Tennessee Health Science Center. A ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based ... its new True North Conference Center. The medical community, social workers, law enforcement, ... may be more aligned in the effort to better understand and combat sex ...
(Date:7/31/2015)... ... July 31, 2015 , ... M3 USA MDLinx.com, source of ... three new Board Exam Courses. , The additions of Gastroenterology, Pulmonology and Allergy/Immunology ... from MDLinx makes preparing for the exam easy and painless. MDLinx offers thousands ...
(Date:7/31/2015)... ... , ... According to an article published July 2 on Healio, ... a consensus on the steps that need to be taken to successfully complete several ... consensus on a series of steps that each surgeon must complete for each procedure. ...
Breaking Medicine News(10 mins):Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3
... Radiation Oncology (ASTRO) has released evidence-based guidelines to ... finding that hypofractionated (HF) WBI is effective for ... are published in the International Journal of ... , Studies have shown that WBI following breast ...
... that controls the number of hematopoietic stem cells cells ... In a report in the online Early Edition of ... from Massachusetts General Hospital (MGH) and the Harvard Stem Cell ... of these blood stem cells, an advance that may improve ...
... By Jenifer Goodwin HealthDay Reporter , ... outbreak of whooping cough in decades, public health officials ... those who come into contact with infants, to make ... With the incidence of whooping cough also higher than ...
... DC Delivering timely, open, online access to the ... will significantly increase the return on the public,s investment ... Houghton at the Centre for Strategic Economic Studies at ... on Investment in Open Archiving Publicly Funded Research Outputs," ...
... Yeni H. Ycel, an ophthalmic pathologist at St. Michael,s Hospital, ... the New York Academy of Medicine. Dr. Ycel received ... the human eye that may lead to new treatments for ... assumption that the eye has no lymphatics, the channels responsible ...
... accurately detect and alleviate symptoms of delirium in persons ... the National Institute of Nursing Research. The project, ... seeks to improve nurses, assessment skills and reduce the ... Delirium and dementia have similar symptoms -- decline in ...
Cached Medicine News:Health News:ASTRO publishes whole breast irradiation guidelines 2Health News:MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment 2Health News:Spread of Whooping Cough Raises Concern 2Health News:Spread of Whooping Cough Raises Concern 3Health News:New study examines the economic returns of public access policies 2Health News:Nurses will test method for determining if it's dementia or delirium 2
(Date:7/30/2015)... OAKS, Calif. , July 30, 2015  Amgen (NASDAQ: ... Hassan , partner and managing director of Warburg Pincus LLC, ... are pleased to welcome Fred Hassan and the ... the Amgen Board," said Robert A. Bradway , chairman ... and commitment to innovation will serve Amgen well." ...
(Date:7/30/2015)... CHAGRIN FALLS, Ohio , July 30, 2015 /PRNewswire/ ... in his OMTEC® 2015 keynote address last month that ... business models in order to gain the efficiencies—and develop ... future. Dr. Barsoum,s comments were preceded by ... Tornier, avid entrepreneur and OMTEC moderator, who stressed that ...
(Date:7/30/2015)... , July 30, 2015  Growth of the ... as they bring former prescription users to the OTC ... Kline forecasts robust Rx-to-OTC switch activity over the ... emerging along with many new brands entering the market ... over the next five years (even those with low ...
Breaking Medicine Technology:Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... 2012  Biomerix Corporation announced today that it has received ... tissue repair mesh, a novel composite mesh intended for ... for the temporary bridging of fascial defects.  This approval ... certification in many other parts of the world that ...
... 2012  Sanofi US today announced that the U. S. ... injunction against a Synvisc-One ® (hylan ... ruling allows for a restricted launch of Seikagaku,s product ... prohibits Seikagaku from selling their product below the current ...
Cached Medicine Technology:Biomerix Receives CE Mark Approval For ASSURE Soft Tissue Repair Mesh 2Sanofi Announces Court Ruling Granting Preliminary Injunction Against Synvisc-One® Competitor Product 2
Reagent Basin, 60mL, 5/Box...
For use with 8 channel pipets....
96 channel Parallel dispenser using Positive Air Displacement Technology...
Manufacturer of the WellPro since 1992, ProGroup previously distributed the instrument through Denley and Labsystems. A direct replacement for the ProPette the WellPro performs serial dilutions in an...
Medicine Products: