Navigation Links
Possible ovarian cancer treatment target identified
Date:12/8/2009

A multi-institutional study has identified a potential personalized treatment target for the most common form of ovarian cancer. In the December 8 issue of Cancer Cell, the research team describes finding that a gene called MAGP2 not previously associated with any type of cancer was overexpressed in papillary serous ovarian tumors of patients who died more quickly. They also found evidence suggesting possible mechanisms by which MAGP2 may promote tumor growth.

"Ovarian cancer is typically diagnosed at an advanced stage when it is incurable, and the same treatments have been used for virtually all patients," says Michael Birrer, MD, PhD, director of medical gynecologic oncology in the Massachusetts General Hospital (MGH) Cancer Center, the study's corresponding author. "Previous research from my lab indicated that different types and grades of ovarian tumors should be treated differently, and this paper now shows that even papillary serous tumors have differences that impact patient prognosis." Birrer was with the National Institutes of Health when this study began and joined the MGH Cancer Center in 200?.

The fifth most common malignancy among U.S. women, ovarian cancer is expected to cause close to 15,000 deaths during 2009. Accounting for 60 percent of ovarian cancers, papillary serous tumors are typically diagnosed after spreading beyond the ovaries. The tumors typically return after initial treatment with surgery and chemotherapy, but while some patients die a few months after diagnosis, others may survive five years or longer while receiving treatment.

To search for genes expressed at different levels in patients with different survival histories, which could be targets for new treatments, the researchers conducted whole-genome profiling of tissue samples that had been microdissected reducing the presence of non-tumor cells from 53 advanced papillary serous ovarian tumors. Of 16 genes that appeared to have t
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fairbank Farms Voluntarily Recalls 85% Ground Round Beef Patties Sold Fresh from Shaws Due to Possible Health Risk
2. M.D. Anderson-led team reports possible key to autoimmune disease
3. AHRQ and FDA to Collaborate in Largest Study Ever of Possible Heart Risks with ADHD Medications
4. Possible safer target for anti-clotting drugs found
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. Why it is impossible for some to just say no
7. Saving Millions of Childrens Lives Is Possible
8. Mayo Clinic Proceedings article explores possible link between obesity and viral infections
9. Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer
10. Help for California Fire Evacuees Possible Through Partnership for Prescription Assistance
11. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... ... Healthy Origins® Cognizin® is a trademark for Citicoline, a nutrient that supports ... capsule for those applications which have more of a semi-solid composition. Vegetarian ...
(Date:8/4/2015)... ... 04, 2015 , ... It’s hard to look your best, ... in Santa Barbara, CA is offering the solution by offering an underarm sweat-removing ... and odor glands in the underarms. This simple and permanent solution usually offers ...
(Date:8/4/2015)... ... August 04, 2015 , ... Recent ... have shown a rise in binge drinking among certain populations and ... depression, are continuing to examine trends and evidence to help facilitate health care ...
(Date:8/4/2015)... ... August 04, 2015 , ... They say a picture is worth ... conditions, pictures and medical art can be essential. StayWell, a health solutions company, announced ... Patient Education solutions have been used by physicians and other health care providers for ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... solutions, today announced that Bruce McCalley joins its executive leadership team as Senior ... of sales success at technology companies and expanding global markets with a special ...
Breaking Medicine News(10 mins):Health News:Healthy Origins® Introduces Cognizin® Citicoline in a Vegetarian Capsule 2Health News:Healthy Origins® Introduces Cognizin® Citicoline in a Vegetarian Capsule 3Health News:Simple, Non-Invasive, Permanent Solution To Stop Underarm Sweating in Santa Barbara 2Health News:Simple, Non-Invasive, Permanent Solution To Stop Underarm Sweating in Santa Barbara 3Health News:DARA Responds To International Trends in Binge Drinking 2Health News:DARA Responds To International Trends in Binge Drinking 3Health News:StayWell Offers Instant Downloads, Licensing of Medical Art to Improve Patient Education 2Health News:StayWell Offers Instant Downloads, Licensing of Medical Art to Improve Patient Education 3Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3
... time for cancer patients in Ontario for radiation has fallen, ... need//. These were the results of a study released by ... Ontario has reported that the system quality index launched last ... radiation treatment to 4.7 weeks, from seven weeks in 2002. ...
... study conducted by Dr. Martina Stippler it was found that ... brain injury//. A team at the University Of Pittsburgh Brain ... patients with severe brain injuries. The study results were presented ... Surgeons in San Francisco. ,The results show that ...
... has revealed the possibilities for the development of a ... well as reversible within a few months of discontinuing ... present are limited to condoms, vasectomy and withdrawal. ... either unreliable or as in the case of vasectomy, ...
... (FDA) has categorically ruled out endorsing the use of ... of Medicine report in 1999, which had said that ... conditions like AIDS wasting, chemotherapy induced nausea and vomiting ... statement issued on Thursday, the FDA stated that "no ...
... cancers that results in death among the Britons. This ... tablet// called Xeloda have only been given to NHS ... of Health and Clinical Excellence (NICE) issued guidance recommending ... had cancerous tissue removed at an early stage. Hence ...
... advice of central government, the Madhya Pradesh government banned ... by vets, saying that it was responsible// for 95 ... vultures are indispensable natural scavengers responsible for the disposal ... of epidemics. But when they themselves feed on animals ...
Cached Medicine News:Health News:Chemotherapy Queues in Ontario Stay Steady 2Health News:Male Contraceptives-Soon to be Reliable and Reversible 2
(Date:8/4/2015)... 4, 2015 HeartWare International, Inc . ... invasive, miniaturized circulatory support technologies that are revolutionizing the ... President and Chief Executive Officer, Doug Godshall , ... Annual Growth Conference at 8:30 a.m. EDT on Thursday, ... 12-13, 2015 at the InterContinental Boston. A ...
(Date:8/4/2015)... , Aug. 4, 2015 Levi & Korsinsky ... ("Biogen" or the "Company") (NASDAQGS: BIIB) for possible violations ... and certain of its officers and/or directors have violated ... of 1934.  On Friday, July 24, 2015, prior to ... quarter 2015 financial results. Among other things, the Company ...
(Date:8/4/2015)... CARLSBAD, Calif., Aug. 4, 2015  Isis Pharmaceuticals, Inc. ... $35.6 million and $18.9 million for the three and ... a net loss of $12.1 million and $43.4 million ... financial results were driven primarily by the more than ... quarter related to the upfront payment from Bayer to ...
Breaking Medicine Technology:HeartWare Presentation At The Canaccord Genuity 35th Annual Growth Conference To Be Webcast 2SHAREHOLDER ALERT: Levi & Korsinsky, LLP Announces an Investigation of Biogen Inc. and Its Board of Directors in Connection with Possible Violations of Federal Securities Laws -- BIIB 2Isis Reports Financial Results And Highlights For Second Quarter 2015 2Isis Reports Financial Results And Highlights For Second Quarter 2015 3Isis Reports Financial Results And Highlights For Second Quarter 2015 4Isis Reports Financial Results And Highlights For Second Quarter 2015 5Isis Reports Financial Results And Highlights For Second Quarter 2015 6Isis Reports Financial Results And Highlights For Second Quarter 2015 7Isis Reports Financial Results And Highlights For Second Quarter 2015 8Isis Reports Financial Results And Highlights For Second Quarter 2015 9Isis Reports Financial Results And Highlights For Second Quarter 2015 10Isis Reports Financial Results And Highlights For Second Quarter 2015 11Isis Reports Financial Results And Highlights For Second Quarter 2015 12Isis Reports Financial Results And Highlights For Second Quarter 2015 13Isis Reports Financial Results And Highlights For Second Quarter 2015 14Isis Reports Financial Results And Highlights For Second Quarter 2015 15Isis Reports Financial Results And Highlights For Second Quarter 2015 16
... Endo Pharmaceuticals (Nasdaq: ENDP ) today announced that ... overview at the Stifel Nicolaus Annual Healthcare Conference on Thursday, ... be held at the Four Seasons Hotel in Boston, MA. ... presentation will be available on the company,s website at ...
... (NASDAQ: STXS ) today announced that executive management ... held September 7-9, 2011 in Boston, MA.  Michael P. Kaminski, ... present an overview of the Company on Wednesday, September 7, ... webcast and subsequent archived replay of the presentation will be ...
Cached Medicine Technology:Stereotaxis to Present at the Stifel Nicolaus Healthcare Conference on September 7, 2011 2Stereotaxis to Present at the Stifel Nicolaus Healthcare Conference on September 7, 2011 3
... Freedom leg bags are part ... a versatile line of leg bags, ... the varied needs of our customers. ... several sizes, and constructed of 100% ...
... are part of the Freedom Urinary ... leg bags, kits, and accessories designed ... our customers. These leg bags are ... of 100% latex-free soft, textured medical ...
... line of Personal Catheters® ... you would choose for ... configurations - standard, antibacterial, ... - are based on ...
The Antibacterial Personal Catheter® features a unique silicone composition that provides an antibacterial coated soft outer layer of silicone combined with a firm inner layer....
Medicine Products: