Navigation Links
Possible new combination treatment for cancer
Date:6/19/2014

A few years ago, a molecule known as "JQ1" was developed, which can block so called BET bromodomain proteins. This switch off the known cancer gene MYC thereby preventing cancer cells from dividing.

The discovery was regarded as a major breakthrough. A problem was that JQ1 did not function optimally in animal experiments, and this means that it has not been possible to test the treatment on cancer patients.

New molecule

Jonas Nilsson and his research group have developed, in collaboration with the Canadian company Zenith epigenetics, a new molecule known as "RVX2135", which has been tested in mice with MYC-driven lymphoma. The study will be published this week in the early edition of the prestigious scientific journal PNAS and shows that the new molecule not only causes cancer cells in culture to stop growing, it also causes tumors to die. This means that the mice survive their cancer longer.

"We hypothesized that the new molecule could also switch off the MYC gene. However, our studies show that neither the JQ1 molecule nor the RVX2135 molecule have this property in these types of cells. This means that the mode of action is probably not as simple as we believed," says Jonas Nilsson, Group Leader at the Sahlgrenska Cancer Center.

Increased survival in mice

The scientists in Gothenburg also discovered that the RVX2135 molecule activates the same genes as those activated by molecules known as "HDAC inhibitors", which are already used to treat cancer. The scientists then tested HDAC inhibitors together with the newly discovered molecules and it turned out that the combination increased survival in mice with lymphoma.

"It was also possible to reduce the dose of HDAC inhibitors when used in combination with RVX2135 and this reduced adverse effects. We see this as a breakthrough in the clinical development of this type of treatment," Jonas Nilsson explains.

Further development

Jonas Nilsson has recently founded the Sahlgrenska Translational Melanoma Group together with surgeons and oncologists at the Sahlgrenska University Hospital. This group will investigate whether the treatment can be used also for malignant melanoma.

"The work is challenging, but we believe that the prospects for success with combination treatments are good," says Jonas Nilsson.


'/>"/>

Contact: Krister Svahn
krister.svahn@sahlgrenska.gu.se
0046-031-786-3869
University of Gothenburg
Source:Eurekalert  

Related medicine news :

1. CWRU Dental School and UH Case Medical Center test possible oral cancer detection tool
2. Two new possible drug targets for triple negative breast cancer
3. Migrating stem cells possible new focus for stroke treatment
4. Wayne State to explore adult onset diseases and possible origins during early development
5. Possible explanation for human diseases caused by defective ribosomes
6. Tequila plant is possible sweetener for diabetics -- helps reduce blood sugar, weight
7. Novel marker and possible therapeutic target for cardiovascular calcification identified
8. Study identifies possible new target for future brain cancer drugs
9. Grant supports Cedars-Sinai study of possible links between air pollution and brain cancer
10. Study: Possible new druggable target in Ewings Sarcoma
11. Researchers identify possible explanation for link between exercise & improved prostate cancer outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Possible new combination treatment for cancer
(Date:5/27/2016)... ... May 27, 2016 , ... Beleza Medspa ... fat composition regulations. This is the first time that Coolsculpting is being used ... least every six months to ensure they meet the prescribed body-fat standard, measured by ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... Despite last ... meeting, expect Janet Yellen and company to wait until March 2017 for an interest ... University’s J. Mack Robinson College of Business. , “The Federal Open Market Committee (FOMC) ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... property (IP) to its specialty academic programs. , Answering to the increasing demand ... certificate programs in health law, and environmental and land use law. ,  , ...
(Date:5/26/2016)... , ... May 26, 2016 , ... There are nearly ... than 32 million cancer survivors worldwide. On Sunday, June 5, 2016, communities around the ... National Cancer Survivors Day®. , National Cancer Survivors Day® is an annual worldwide ...
(Date:5/26/2016)... , ... May 26, 2016 , ... In an effort to provide hair restoration information ... both Snapchat users and those who do not use the app. Dr. Mohebi, the founder ... page, Dr. Mohebi Live . , Dr. Mohebi says, “The positive response to ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... May 26, 2016 According to a ... Management Market - U.S. Industry Analysis, Size, Share, Growth, Trends, ... in the U.S. was valued at US$ 5.89 Bn in ... 3.4% from 2015 to 2023 to reach US$ 7.99 Bn ... current and emerging needle free drug delivery devices and the ...
(Date:5/26/2016)... Tenn. , May 26, 2016 /PRNewswire/ ... of software and analytics, network solutions and ... today announced it entered into a strategic ... provider of outpatient software solutions and revenue ... centers, specialty hospitals and rehabilitation clinics to ...
(Date:5/25/2016)... , May 25, 2016 According ... by Type (3D, 2D, 4D), by Therapeutic Area (Oncology, ... End User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast ... global Medical Animation Market for the forecast period of ... USD 301.3 Million by 2021 from USD 117.3 Million ...
Breaking Medicine Technology: