Navigation Links
Possible new cancer treatment identified
Date:4/19/2012

New research findings show how it may be possible to render cancer tumours harmless without affecting the other cells and tissues in the body. The findings apply to cancers including breast, lung and bowel cancer. The study was carried out at Lund University in Sweden.

Many of the most common chemotherapy drugs used to treat cancer have serious side effects because they not only affect the cells in the cancer tumour, but also the cells in the rest of the body.

Researchers at Lund University have now found a connection between two proteins that in different ways control cell division and the possibilities for a cancer tumour to develop. The retinoblastoma protein obstructs cell division and is absent in most types of cancer tumour. The new findings show that its absence leads to an increase in another protein, gamma-tubulin, which, when present in high levels, encourages the development of cancer tumours. However, if gamma-tubulin is blocked, the tumour cells die while the healthy cells survive.

The researchers are now looking for substances that can stop the effect of gamma-tubulin on cell division. This could form the basis for a new drug that works on various types of cancer and has a low risk of side effects if the substance is directed to the right place. This is because it is only the tumour cells that die.

"I judge the chances of finding a basis for a drug to be good, partly because there are already substances that block 'cousins' of gamma-tubulin", says Maria Alvarado-Kristensson, a researcher at Lund University, who believes that, if all goes well, a drug could be ready for initial tests on patients, known as 'phase 1 testing', in 5-6 years' time.

In the study, tissue and genetic material from patients with various different types of cancer were studied: breast cancer, bladder cancer, small-cell lung cancer, colon cancer and eye cancer. The two proteins were seen to play an important role in all these diseases and the protein is also found in a number of other types of cancer tumour.

"It is exciting to have research findings that are significant for several common types of cancer. This means that many patients will be affected if our work proves successful", says Maria Alvarado Kristensson.

The search for effective substances will involve screening a large number of substances, both natural and synthetic.


'/>"/>

Contact: Maria Alvarado Kristensson
Maria.Alvarado-Kristensson@med.lu.se
46-403-38391
Lund University
Source:Eurekalert

Related medicine news :

1. Researchers find possible genetic keys to surviving epithelial ovarian cancer
2. Researchers discover possible approach to the treatment of aggressive breast cancer
3. New hybrid NOSH aspirin as possible anti-cancer drug
4. Possible new pathway can overcome glioblastoma resistance
5. Women advised to avoid ZEN bust-enhancing supplements because of possible cancer risk
6. Cleveland researchers find possible breakthrough to relieve pain following spinal cord injury
7. Dana-Farber/Childrens Hospital Boston study identifies possible therapy for radiation sickness
8. Carotid artery stenting possible for high risk patients with lesions
9. Possible Genetic Link to Autism Identified
10. Its Possible to Come Down With Two Flu Viruses at Once
11. Precise early diagnosis of psychotic disorders possible
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... Brenntag Specialties, Inc.(BSI) , is pleased ... Beverage and Dietary Supplement market segments across the western United ... east of the Rocky Mountains since 2012. Consistent performance in business development ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... Houma, LA, celebrates the beginning of a new charity campaign. As part of ... Appointed Special Advocates (CASA). In the belief that children deserve a voice, and ...
(Date:2/8/2016)... ... February 08, 2016 , ... A man who has struggled to quit smoking, a man ... , was determined to find solutions to his problems – and he did. Now Nabat, ... is ready to introduce his breakthrough inventions to the world and better people's lives. His ...
(Date:2/8/2016)... New York, NY (PRWEB) , ... February 08, 2016 , ... ... handles are too much to handle, you are not alone. According to the Center ... conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some ...
(Date:2/8/2016)... , ... February 08, 2016 , ... Steve Helwig & ... a vital new community enrichment program, has teamed up with Citizens Opposed to Domestic ... suffering from intimate abuse. To support all those victimized by the fear of violence ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 The new report "Global ... Business Research & Consulting group reveals that global diagnostic ultrasound devices ... to grow to US$ 7,466.3 million by 2019 at a CAGR ... analysis of global ultrasound market has been analyzed for six geographies ... , Asia-Pacific , Latin America ...
(Date:2/9/2016)... This TforG report includes the Surgical Procedures ... coding system in South Korea . ... report provides written and numerical analysis on the current ... addition, the latest reforms of the local Healthcare system ... --> The report helps businesses gain a unique ...
(Date:2/9/2016)... HONG KONG , Feb. 9, 2016 /PRNewswire/ ... PhD, has joined Athenex as Vice President of Corporate Strategy ... Raymond Yeung , MSc, MBA has joined as Senior Director and ... Hong Kong . Simon Pedder ... I have known for a while. Coupled together with their ...
Breaking Medicine Technology: