Navigation Links
Possible new blood test to diagnose heart attacks
Date:9/20/2011

MAYWOOD, Ill. -- Loyola University Chicago Stritch School of Medicine researchers are reporting a possible new blood test to help diagnose heart attacks.

In the Journal of Molecular and Cellular Cardiology, researchers report that a large protein known as cardiac myosin binding protein-C (cMyBP-C) is released to the blood following a heart attack.

"This potentially could become the basis for a new test, used in conjunction with other blood tests, to help diagnose heart attacks," said senior author Sakthivel Sadayappan, PhD. "This is the beginning. A lot of additional studies will be necessary to establish cMyBP-C as a true biomarker for heart attacks."

Sadayappan is an assistant professor in the Department of Cell and Molecular Physiology at Loyola University Chicago Stritch School of Medicine. First author is Suresh Govindan, PhD, a postdoctoral researcher in Sadayappan's lab.

Between 60 and 70 percent of all patients who complain of chest pain do not have heart attacks. Many of these patients are admitted to the hospital, at considerable time and expense, until a heart attack is definitively ruled out.

An electrocardiogram can diagnose major heart attacks, but not minor ones. There also are blood tests for various proteins associated with heart attacks. But most of these proteins are not specific to the heart. Elevated levels could indicate a problem other than a heart attack, such as a muscle injury.

Only one protein now used in blood tests, called cardiac troponin-I, is specific to the heart. But it takes at least four to six hours for this protein to show up in the blood following a heart attack. So the search is on for another heart attack protein that is specific to the heart.

The Loyola study is the first to find that cMyBP-C is associated with heart attacks. The protein is specific to the heart. And it may be readily detectable in a blood test because of its large molecular size and relatively high concentration in the blood.

Researchers evaluated blood samples from heart attack patients. They also evaluated rats that had experienced heart attacks. They found that in both humans and rats, cMyBP-C was elevated significantly following heart attacks.

Sadayappan said cMyBP-C is a large assembly protein that stabilizes heart muscle structure and regulates cardiac function. During a heart attack, a coronary artery is blocked, and heart muscle cells begin to die due to lack of blood flow and oxygen. As heart cells die, cMyPB-C breaks into fragments and is released into the blood.

"Future studies," Sadayappan and colleagues wrote, "would determine the time course of release, peak concentrations and half life in the circulatory system."


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert  

Related medicine news :

1. Study suggests possible link between two Type 2 diabetes drugs and pancreatic cancer
2. Moffitt researchers find possible key to preventing chemotherapy resistance in ovarian cancer
3. University of Maryland researchers discover possible drug targets for common non-Hodgkins lymphoma
4. Scientists Spot Possible Target in Ovarian Cancer
5. New research points to a possible gender link in knee injuries
6. Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
7. Study reveals possible brain damage in young adult binge-drinkers
8. Poor Brain Sync a Possible Sign of Autism
9. Possible susceptibility genes found in neurodegenerative disorder
10. Chemical Found in Foam Cups a Possible Carcinogen
11. Earpieces Can Minimize Possible Risks From Cellphones, Experts Say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Possible new blood test to diagnose heart attacks
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/26/2016)... , June 26, 2016 ... value-based care operating models within the health care industry ... greater financial efficiency , Deloitte offers a suite ... key business issues impacting efficient cost optimization: labor resource ... , These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
Breaking Medicine Technology: