Navigation Links
Possible link between immune system and Alzheimer's
Date:11/14/2012

An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene which helps trigger immune system responses is also associated with increased risk of Alzheimer's. The discovery supports an emerging theory about the role of the immune system in the disease.

"This discovery provides an increasingly firm link between brain inflammation and increased risk for Alzheimer's," says Dr. Peter St George-Hyslop, director of U of T's Tanz Centre for Research in Neurodegenerative Diseases. "This is an important step towards unraveling the hidden causes of this disease, so that we can develop treatments and interventions to end one of the 21st century's most significant health challenges."

St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, says the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research."

The team began by sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people. The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. One mutation known as R47H had a particularly strong association with the disease.

The mutation makes a patient three times more likely to develop the disease, although it affects just 0.3 per cent of the population.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease," says Dr. Rita Geurreiro from UCL, the study's lead author.

The study is published now in the New England Journal of Medicine.


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Related medicine news :

1. Study Explores Possible Tie Between Fever, Flu in Pregnancy and Autism
2. New cell type developed for possible treatment of Alzheimers and other brain diseases
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Researchers identify possible key to slow progression toward AIDS
5. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
6. Its Possible to Be Obese and Heart-Healthy: Studies
7. Possible new therapy for the treatment of a common blood cancer
8. Study suggests possible association between cardiovascular disease, chemical exposure
9. Possible therapy for tamoxifen resistant breast cancer identified
10. Statin Use Tied to Possible Boost in Cataract Risk
11. FDA Cites Possible Source of Cantaloupe-Salmonella Outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin ... companies that call for a minimum wage raise to $12 an hour by 2020 and ... This will restore the lost value of the minimum wage, assure the wage floor does ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dublin ... the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global market ... its applications in various applications. The report deals with ... main industries: pharmaceutical and biotechnology, food and beverage, and ...
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
Breaking Medicine Technology: