Navigation Links
Possible link between immune system and Alzheimer's
Date:11/14/2012

An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene which helps trigger immune system responses is also associated with increased risk of Alzheimer's. The discovery supports an emerging theory about the role of the immune system in the disease.

"This discovery provides an increasingly firm link between brain inflammation and increased risk for Alzheimer's," says Dr. Peter St George-Hyslop, director of U of T's Tanz Centre for Research in Neurodegenerative Diseases. "This is an important step towards unraveling the hidden causes of this disease, so that we can develop treatments and interventions to end one of the 21st century's most significant health challenges."

St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, says the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research."

The team began by sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people. The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. One mutation known as R47H had a particularly strong association with the disease.

The mutation makes a patient three times more likely to develop the disease, although it affects just 0.3 per cent of the population.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease," says Dr. Rita Geurreiro from UCL, the study's lead author.

The study is published now in the New England Journal of Medicine.


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Related medicine news :

1. Study Explores Possible Tie Between Fever, Flu in Pregnancy and Autism
2. New cell type developed for possible treatment of Alzheimers and other brain diseases
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Researchers identify possible key to slow progression toward AIDS
5. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
6. Its Possible to Be Obese and Heart-Healthy: Studies
7. Possible new therapy for the treatment of a common blood cancer
8. Study suggests possible association between cardiovascular disease, chemical exposure
9. Possible therapy for tamoxifen resistant breast cancer identified
10. Statin Use Tied to Possible Boost in Cataract Risk
11. FDA Cites Possible Source of Cantaloupe-Salmonella Outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... East Los Angeles dentist ... patients can visit Dr. Assili to receive any dental extraction treatment for $40 off ... expires June 30, 2016. With the lower price, patients can more easily afford extractions ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Rassouli, dentist in Orange ... decline. According to the research, which was published in the “Journal of the American ... and about 5.4 million Americans have Alzheimer’s disease. The study found that dental problems ...
(Date:5/2/2016)... ... 2016 , ... Pregnancy Awareness Month offers a great time to get familiar ... you are ready to have a baby, it’s best to get started before age ... your Personal Conception & Pregnancy Organizer, written for women who plan on becoming pregnant ...
(Date:5/2/2016)... NC (PRWEB) , ... May 02, 2016 , ... Dr. Jonathan Kulbersh of Carolina Facial ... listed as number five on the list of “ 5 US Cities with the Highest ... Francisco, Los Angeles, and Miami. The results were calculated using a survey by ...
(Date:5/2/2016)... FL (PRWEB) , ... May 02, 2016 , ... The ... great pain and suffering. With no cure, most patients must deal with prescription costs ... free coupon card, allowing up to 75% savings at the pharmacy on many common ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...  The blood testing market in China ... Information and The Freedonia Group in a recent report.  ... The healthcare research firm said that China ... stations and in improving testing at the provincial level.  ... Blood Testing Market in China , which ...
(Date:4/28/2016)... April 28, 2016 Dr. Vivek ... and Ste phen Schmidt ... a leading provider of cloud-based software solutions for life sciences, today ... to bring a wealth of insight to a growing business.  This ... George Phillips joined ArisGlobal in the position ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
Breaking Medicine Technology: