Navigation Links
Possible link between immune system and Alzheimer's
Date:11/14/2012

An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene which helps trigger immune system responses is also associated with increased risk of Alzheimer's. The discovery supports an emerging theory about the role of the immune system in the disease.

"This discovery provides an increasingly firm link between brain inflammation and increased risk for Alzheimer's," says Dr. Peter St George-Hyslop, director of U of T's Tanz Centre for Research in Neurodegenerative Diseases. "This is an important step towards unraveling the hidden causes of this disease, so that we can develop treatments and interventions to end one of the 21st century's most significant health challenges."

St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, says the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research."

The team began by sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people. The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. One mutation known as R47H had a particularly strong association with the disease.

The mutation makes a patient three times more likely to develop the disease, although it affects just 0.3 per cent of the population.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease," says Dr. Rita Geurreiro from UCL, the study's lead a
'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Explores Possible Tie Between Fever, Flu in Pregnancy and Autism
2. New cell type developed for possible treatment of Alzheimers and other brain diseases
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Researchers identify possible key to slow progression toward AIDS
5. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
6. Its Possible to Be Obese and Heart-Healthy: Studies
7. Possible new therapy for the treatment of a common blood cancer
8. Study suggests possible association between cardiovascular disease, chemical exposure
9. Possible therapy for tamoxifen resistant breast cancer identified
10. Statin Use Tied to Possible Boost in Cataract Risk
11. FDA Cites Possible Source of Cantaloupe-Salmonella Outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Surviving Mesothelioma says thousands of water pipes in the ... can leach asbestos into drinking water as they age. ... the Surviving Mesothelioma website. , According to the EPA, ... water mains made of asbestos cement are the major source ... consumers from mesothelioma , water providers are subject to routine ...
(Date:12/19/2014)... B. E. Smith, the only full-service ... been retained to lead a national chief financial ... Estes Park, Colo. The top executive search firm in ... more than 900 healthcare executives into organizations. , ... critical access hospital and level IV trauma center, with ...
(Date:12/19/2014)... December 19, 2014 Novellus Healthcare ... Care: Pharmacy & Clinics™, an independent journal that ... treating and caring for patients inside the pharmacy ... expands to provide optimal access to quality care, ... forum for the team treating and coordinating patient ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 If you ... having difficulty breathing, you probably wished you had an ... asthma, COPD, cystic fibrosis, and other breathing disorders. Currently, ... medications and avoiding triggers, but other common treatments do ... Educators conference in San Antonio, TX, 34 asthma educators ...
(Date:12/19/2014)... December 19, 2014 After a 13-year ... is again returning to the stage to entertain his ... for concert performances, and the successful tour has been ... announced. , Visit Ticketability.com for a ... Detroit shows at fair prices. , Music fans have ...
Breaking Medicine News(10 mins):Health News:Surviving Mesothelioma Warns of Potential Mesothelioma Risk from Cement Water Pipes 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Estes Park Medical Center Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2
... ... cut down on road accidents , ... York, New York (PRWEB) March 26, 2010 -- With the arrival of spring, more cyclists are ... an increasing number of people sharing the road with drivers and pedestrians., , , , ,This ...
... ... relax patients, treat TMJ disorders and improve dental procedures. , ... Miami, FLA. (PRWEB) -- In addition to cosmetic dentistry services, ... at Miami Beach Dental Institute now offer dental massage to patients. Dr. Nassery teams up ...
... Barcelona, Spain: Women who discover they have breast cancer ... without endangering the health of their unborn baby, according ... Breast Cancer Conference (EBCC7) in Barcelona today (Friday). ... at the University of Frankfurt, Germany, and a member ...
... Mexican Americans are 40 percent less likely than non-Hispanic whites ... ambulance for stroke resulting in medical treatment delays ... of the American Heart Association ., For the study, researchers ... Texas (BASIC project) to compare hospital arrival time and use ...
... with a coalition of 20 international sites in five ... who have had optical coherence tomography (OCT) of the ... researchers hope will give doctors a better means to ... and sudden cardiac death. When a vulnerable ...
... researchers say , THURSDAY, March 25 (HealthDay News) -- New ... breast cancer may actually improve their survival odds, a notion ... The finding is significant, given that the death rate from ... delaying pregnancy until later in life, the study authors said. ...
Cached Medicine News:Health News:New York Personal Injury Attorney Interprets Increase in Tickets for Cyclists as Effort to Make Streets Safer 2Health News:Top Miami Dentist, Dr. Hamid Nassery, Offers Dental Massage Services For Patients 2Health News:Pregnant women can receive breast cancer chemotherapy without endangering health of their babies 2Health News:Pregnant women can receive breast cancer chemotherapy without endangering health of their babies 3Health News:Mexican Americans less likely than whites to call 9-1-1 for stroke 2Health News:Mexican Americans less likely than whites to call 9-1-1 for stroke 3Health News:Mass. General Hospital to create registry for coronary optical coherence tomography 2Health News:Pregnancy May Protect Breast Cancer Survivors 2Health News:Pregnancy May Protect Breast Cancer Survivors 3
(Date:12/19/2014)... -- In the Friday, December 19 edition of USA ... Technology (HIT) features Konica Minolta, the company announced today. The supplement ... leading healthcare organizations. In addition to the print ... as New York , Chicago ... Minneapolis and San Francisco ...
(Date:12/19/2014)... 19, 2014 TODAY, AEGATE, the ... World announced the appointment of Peter Fox ... Chief Channels and Partner Officer. Peter has ... to its acquisition by Oracle in 2011. ... Geneva and subsequently Convergys, a world ...
(Date:12/19/2014)... , Dec. 19, 2014  Newport Corporation (NASDAQ: ... Kadia, Ph.D. has joined the company,s Board of ... Officer and a director of Evans Analytical Group, ... evaluation and analytical services to companies in a ... to joining Evans Analytical Group, Dr. Kadia spent ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2
... Amarin Corporation plc (Nasdaq: AMRN ) ... on cardiovascular disease, today announced that, in connection with ... Shares ("ADSs"), the underwriters of the offering have exercised ... aggregate of 1,800,000 additional ADSs to cover over-allotments.  The ...
... 7, 2011 Echo Therapeutics, Inc. (OTC Bulletin Board: ... Symphony™ tCGM System as a non-invasive, wireless, transdermal continuous ... transdermal drug delivery, today announced that Patrick T. Mooney, ... Echo Therapeutics will present at the OneMedForum 2011 annual ...
Cached Medicine Technology:Amarin Announces Underwriters' Exercise of Over-Allotment Option 2Amarin Announces Underwriters' Exercise of Over-Allotment Option 3Amarin Announces Underwriters' Exercise of Over-Allotment Option 4Echo Therapeutics to Present at the OneMedForum 2011 Conference 2
Inquire...
... offered as either EDTA K2 or ... calcium ions and therefore blocks the ... in an EDTA anticoagulated blood sample ... hours. EDTA tubes are for the ...
... is a ubiquitous enzyme that catalyzes ... is also the specific protein that ... immunofluorescence (EMA) tests (Bio-Rad catalog number ... IgG serologic tests are highly sensitive ...
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
Medicine Products: