Navigation Links
Possible link between immune system and Alzheimer's
Date:11/14/2012

An international research team including scientists from the University of Toronto's Faculty of Medicine has discovered a link between a mutation in an immune system gene and Alzheimer's disease.

Using data from 25,000 people, researchers from the Faculty of Medicine and University College London's Institute of Neurology discovered that a rare genetic mutation in the TREM2 gene which helps trigger immune system responses is also associated with increased risk of Alzheimer's. The discovery supports an emerging theory about the role of the immune system in the disease.

"This discovery provides an increasingly firm link between brain inflammation and increased risk for Alzheimer's," says Dr. Peter St George-Hyslop, director of U of T's Tanz Centre for Research in Neurodegenerative Diseases. "This is an important step towards unraveling the hidden causes of this disease, so that we can develop treatments and interventions to end one of the 21st century's most significant health challenges."

St George-Hyslop, renowned for identifying five genes associated with Alzheimer's disease, says the breakthrough is, "another win for U of T scientists who are building on a worldwide legacy of expertise in neurodegenerative research."

The team began by sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people. The results showed several mutations in the TREM2 gene occurred more frequently in people who had the disease than in those without the disease. One mutation known as R47H had a particularly strong association with the disease.

The mutation makes a patient three times more likely to develop the disease, although it affects just 0.3 per cent of the population.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease," says Dr. Rita Geurreiro from UCL, the study's lead author.

The study is published now in the New England Journal of Medicine.


'/>"/>

Contact: Nicole Bodnar
nicole.bodnar@utoronto.ca
416-978-5811
University of Toronto
Source:Eurekalert

Related medicine news :

1. Study Explores Possible Tie Between Fever, Flu in Pregnancy and Autism
2. New cell type developed for possible treatment of Alzheimers and other brain diseases
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Researchers identify possible key to slow progression toward AIDS
5. Metabolic engineer synthesizes key breast milk ingredient, makes research possible
6. Its Possible to Be Obese and Heart-Healthy: Studies
7. Possible new therapy for the treatment of a common blood cancer
8. Study suggests possible association between cardiovascular disease, chemical exposure
9. Possible therapy for tamoxifen resistant breast cancer identified
10. Statin Use Tied to Possible Boost in Cataract Risk
11. FDA Cites Possible Source of Cantaloupe-Salmonella Outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... January 15, 2017 , ... Accreditation Commission for ... for its specialty care services. Albertsons Companies is the largest national food ... for pharmacy patients. , Accreditation by ACHC reflects Albertsons Companies’ dedication and commitment ...
(Date:1/15/2017)... IL (PRWEB) , ... January 14, 2017 , ... Wondering ... Lobster Gram Dinner delivered straight to your door for a romantic, lobster feast in ... just in time for Valentine's Day. The dinners will be featured until February ...
(Date:1/14/2017)... ... 14, 2017 , ... Healthy living brand Moody Zook recently ... products. With more and more people opting to go organic in their lifestyle, ... cater to specific needs. , Moody Zook focused particularly on their newly launched ...
(Date:1/14/2017)... (PRWEB) , ... January 14, 2017 , ... "TransFreeze Volume 3 is a self animating ... mask effect in Final Cut Pro X," said Christina Austin - CEO of Pixel Film ... a unique freeze frame transition from one clip to the next. , To ...
(Date:1/13/2017)... ... January 13, 2017 , ... A January 10 article ... for 2017 according to the publication, with an emphasis on some new techniques that ... F.I.C.S., F.A.C.S., who is known more casually to his patients and colleagues as Dr. ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... , January 16, 2017 ... Derivatives Market by Product Type (Methyl, Ethyl, Hydroxyethyl, ... Foods & Beverages, Surface Coatings & Paints), ... by MarketsandMarkets, the market was valued at ... projected to reach USD 6.41 Billion by ...
(Date:1/16/2017)... , Jan. 16, 2017  Dovetail Genomics today announced ... and assembly service, which yields chromosome-scale genome assemblies. The ... a Dovetail-hosted workshop on Jan. 17 at the Plant ... San Diego . "We are thrilled ... launch of our Dovetail Hi-C offering," said Todd ...
(Date:1/15/2017)... , January 16, 2017 Der ... Kollagenprodukten für die Regeneration des menschlichen Gewebes, gibt die ... mit sofortiger Wirkung bekannt. ... Bill Allan ... Er bekleidete eine Reihe von Geschäftsführer- und anderen Führungspositionen ...
Breaking Medicine Technology: