Navigation Links
Possible link between different forms of epilepsy found by Carnegie Mellon scientists
Date:6/16/2008

PITTSBURGHCarnegie Mellon University neuroscientists have identified what may be the first known common denominator underlying inherited and sporadic epilepsy a disruption in an ion channel called the BK channel. Although BK channels have been linked to a rare, familial form of epilepsy, their involvement in other types of seizure disorders has never been demonstrated. These findings, published in the June issue of Neurobiology of Disease, indicate that BK channels are a new target for anticonvulsant therapies, and offer new hope to individuals suffering from epilepsy.

The researchers discovered that BK channels become abnormally active after a seizure. This disruption results in the neurons becoming overly excitable, which may be associated with the development of epilepsy. The Carnegie Mellon scientists were able to reverse this abnormal excitability using a BK channel antagonist, which returned the post-seizure electrical activity to normal levels.

"The fact that the BK channel previously has been linked with familial epilepsy and with generalized seizures in subjects without a genetic predisposition points to a common therapeutic pathway. We've shown that BK antagonists can be very effective in normalizing aberrant electrical activity in neurons, which suggests that BK channel antagonists might be a new weapon in the arsenal against epilepsy," said Alison Barth, an assistant professor of biological sciences at Carnegie Mellon's Mellon College of Science.

Epilepsy is a neurological disorder marked by abnormal electrical activity in the brain that leads to recurring seizures. According to the Epilepsy Foundation, no cause can be found in about seven out of 10 people with epilepsy. Researchers, however, have identified a genetic component in some types of epilepsy. This study establishes, for the first time, a shared component between different types of epilepsy.

"Although research has revealed that many types of inherited epilepsy are linked to mutations in different ion channels, there has been little overlap between these ion channels and those channels that are affected by sporadic or acquired forms of epilepsy," Barth said. "BK channels could represent a common pathway activated in familial and sporadic cases of epilepsy."

The BK channel allows electrically charged potassium ions into and out of cells. This activity starts and stops the electrical impulses by which neurons communicate with one another. Barth and her colleagues were specifically interested in investigating BK channels' function following a first seizure. Their in vitro studies revealed that, after a seizure, BK channel function was enhanced neurons fired quicker, stronger and more spontaneously. This abnormal activity might underlie the transition between a single seizure and the emergence of epilepsy, characterized by recurrent seizures.

"We found that seizures caused cells to become more excitable, and that BK channel antagonists bring everything back to normal. These channels are at a nexus of control and represent a new target for anticonvulsant therapies," Barth said.

It is also possible that BK channel antagonists could be used early, perhaps after an initial seizure, to prevent cellular changes that lead to epilepsy, according to Barth.


'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Related medicine news :

1. Possible biological explanation for C-Section-linked allergies and asthma found
2. Blood test for lung cancer may be possible
3. WorldHeart Announces Possible Delisting Action by NASDAQ
4. Possible Viral Links to Lung Cancer Risk Uncovered
5. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
6. FDA Probing Possible Link Between Asthma Drug and Suicide Risk
7. NARSADs 5th Annual Mission Possible Symposium Offers Insight to PTSD and Other Mental Illnesses
8. Possible Reason for Rimonabants Side Effects Discovered
9. Teamsters Warn of Possible Work Stoppages, Service Disruptions at AmerisourceBergen
10. Researchers find possible target to treat deadly bloodstream infections
11. Brain stress system presents possible treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
Breaking Medicine Technology: