Navigation Links
Possible link between different forms of epilepsy found by Carnegie Mellon scientists

PITTSBURGHCarnegie Mellon University neuroscientists have identified what may be the first known common denominator underlying inherited and sporadic epilepsy a disruption in an ion channel called the BK channel. Although BK channels have been linked to a rare, familial form of epilepsy, their involvement in other types of seizure disorders has never been demonstrated. These findings, published in the June issue of Neurobiology of Disease, indicate that BK channels are a new target for anticonvulsant therapies, and offer new hope to individuals suffering from epilepsy.

The researchers discovered that BK channels become abnormally active after a seizure. This disruption results in the neurons becoming overly excitable, which may be associated with the development of epilepsy. The Carnegie Mellon scientists were able to reverse this abnormal excitability using a BK channel antagonist, which returned the post-seizure electrical activity to normal levels.

"The fact that the BK channel previously has been linked with familial epilepsy and with generalized seizures in subjects without a genetic predisposition points to a common therapeutic pathway. We've shown that BK antagonists can be very effective in normalizing aberrant electrical activity in neurons, which suggests that BK channel antagonists might be a new weapon in the arsenal against epilepsy," said Alison Barth, an assistant professor of biological sciences at Carnegie Mellon's Mellon College of Science.

Epilepsy is a neurological disorder marked by abnormal electrical activity in the brain that leads to recurring seizures. According to the Epilepsy Foundation, no cause can be found in about seven out of 10 people with epilepsy. Researchers, however, have identified a genetic component in some types of epilepsy. This study establishes, for the first time, a shared component between different types of epilepsy.

"Although research has revealed that many types of inherited epilepsy are linked to mutations in different ion channels, there has been little overlap between these ion channels and those channels that are affected by sporadic or acquired forms of epilepsy," Barth said. "BK channels could represent a common pathway activated in familial and sporadic cases of epilepsy."

The BK channel allows electrically charged potassium ions into and out of cells. This activity starts and stops the electrical impulses by which neurons communicate with one another. Barth and her colleagues were specifically interested in investigating BK channels' function following a first seizure. Their in vitro studies revealed that, after a seizure, BK channel function was enhanced neurons fired quicker, stronger and more spontaneously. This abnormal activity might underlie the transition between a single seizure and the emergence of epilepsy, characterized by recurrent seizures.

"We found that seizures caused cells to become more excitable, and that BK channel antagonists bring everything back to normal. These channels are at a nexus of control and represent a new target for anticonvulsant therapies," Barth said.

It is also possible that BK channel antagonists could be used early, perhaps after an initial seizure, to prevent cellular changes that lead to epilepsy, according to Barth.


Contact: Jocelyn Duffy
Carnegie Mellon University

Related medicine news :

1. Possible biological explanation for C-Section-linked allergies and asthma found
2. Blood test for lung cancer may be possible
3. WorldHeart Announces Possible Delisting Action by NASDAQ
4. Possible Viral Links to Lung Cancer Risk Uncovered
5. Mayo Clinic Proceedings Examines a Possible Link Between Bacteria Found in the Human Digestive System and Obesity
6. FDA Probing Possible Link Between Asthma Drug and Suicide Risk
7. NARSADs 5th Annual Mission Possible Symposium Offers Insight to PTSD and Other Mental Illnesses
8. Possible Reason for Rimonabants Side Effects Discovered
9. Teamsters Warn of Possible Work Stoppages, Service Disruptions at AmerisourceBergen
10. Researchers find possible target to treat deadly bloodstream infections
11. Brain stress system presents possible treatment
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: