Navigation Links
Possible biological explanation for C-Section-linked allergies and asthma found
Date:5/21/2008

ATS 2008, TORONTOXScientists believe they may have identified a biological explanation for the link between cesarean-section delivery and risk of allergy and asthma in childhood. They will present their findings at the American Thoracic Societys 2008 International Conference in Toronto on Tuesday, May 20.

Several studies have shown immunological differences between children with and without allergy at the time of birth. For example, increased cord blood levels of IL-13, a Th2 type cytokine, have been positively associated with allergy among children with a family history of allergy

Regulatory T cells are a subgroup of T lymphocytes with immune suppressive properties on effector T cells, which in turn regulate cytokine secretion and the development and function of the immune system. Evidence suggests that CD4+CD25+ T regulatory (Treg) cells in those with asthma or allergy may be functionally impaired.

"Our research looked at the effect of cesarean-section versus vaginal delivery in newborns to determine whether cesarean-section was associated with reduced regulatory T-cell function," said lead researcher Ngoc Ly, M.D., M.P.H., who is assistant professor of pediatrics at the University of California, San Francisco.

In a previous study Dr. Ly and colleagues demonstrated an association between cesarean section and increased neonatal secretion of IL-13. In this latest study, the researchers measured the expression and function of specific regulatory T-cells in the cord blood of 50 newborns born by cesarean section, and 68 delivered vaginally, all of whose have at least one parent with allergies and/or asthma. They found that babies born by cesarean section showed a reduction in the suppressive function of their regulatory T-cells. There was a trend for lower level of TGF-, a cytokine secreted by tregs, and higher level of IL-4 and IL-13 among children born by c-section as compared to children born by vaginal delivery.

"This finding is exciting because it suggests that the mode of delivery may be an important factor influencing immune system development in the neonate," said Dr. Ly, who postulated that the stress and process of labor itself or exposure to specific microbes through the birth canal in vaginal as compared to c-section delivery may influence neonatal immune responses.

"These findings are preliminary and further work is needed to explore potential mechanisms for the association between mode of delivery and neonatal immune responses," she/he" explained. "However, this finding provided a potential immunologic basis for previous reports of the association among cesarean section, elevated IL-13 and allergy and asthma."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Fairbank Farms Voluntarily Recalls 85% Ground Round Beef Patties Sold Fresh from Shaws Due to Possible Health Risk
2. M.D. Anderson-led team reports possible key to autoimmune disease
3. AHRQ and FDA to Collaborate in Largest Study Ever of Possible Heart Risks with ADHD Medications
4. Possible safer target for anti-clotting drugs found
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. Why it is impossible for some to just say no
7. Saving Millions of Childrens Lives Is Possible
8. Mayo Clinic Proceedings article explores possible link between obesity and viral infections
9. Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer
10. Help for California Fire Evacuees Possible Through Partnership for Prescription Assistance
11. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... 2016 , ... For the 10,000 Americans who turn 65 on any given ... overall well-being: mental health. Now, a new book—Staying Sharp For Dummies (Paper; ISBN: 978-1-119-18779-0; ... which can include everything from honing your memory and managing stress to eating healthy ...
(Date:4/28/2016)... ... 2016 , ... Boston Laser is now offering a novel treatment for Keratoconus ... of the application of Riboflavin, a vitamin, to the cornea. This, combined with UV ... cornea to slow the progression of keratoconus. , Keratoconus is the continuous thinning and ...
(Date:4/28/2016)... ... April 28, 2016 , ... The USDA recently released its updated ... latest nutritional science. While there is a lot of information available in the report, ... the April 2016 issue of Harvard Men's Health Watch . , These ...
(Date:4/28/2016)... ... April 28, 2016 , ... Zerorez Franchising Systems, ... March 2-4. The conference featured several collaborative breakout sessions, presentations, an award banquet, ... franchisees felt they were given tools and resources to assist with operational growth ...
(Date:4/28/2016)... ... 2016 , ... It was the five star ratings and excellent reviews by ... Top Rated Atlanta Plastic Surgeon by Find Local Doctors. Dr. ... Specialists, P.C. This recognition is one of many achievements and awards that Dr. Jones ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... YORK , April 28, 2016  The blood ... 275 million dollars, according to Kalorama Information and The ... typing, immunoassays and nucleic acid testing.  The healthcare research ... made progress in developing blood collection stations and in ... made in Kalorama Information,s report, Blood Testing ...
(Date:4/28/2016)... Dr. Vivek Ahuja , ... phen Schmidt Join the Growing ... solutions for life sciences, today announced key new leaders have joined ... to a growing business.  This will bolster the company,s safety business ... joined ArisGlobal in the position of Vice President - Safety. George ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
Breaking Medicine Technology: