Navigation Links
Possible association between CP and LC of alcoholic etiology
Date:11/11/2008

Chronic alcoholism is a well-known etiologic factor associated with chronic and irreversible pancreatic and liver disorders. There is a correlation between increased ethanol consumption through many years and the risk of developing chronic pancreatitis (CP). An excessive consumption of alcohol is also associated with liver cirrhosis (LC), again with a correlation between increased ethanol consumption and the risk of LC. In clinical practice, the coincidence of both diseases, LC and CP, is rare. Furthermore, these two diseases do not share risk factors apart from alcohol consumption.

A research group leaded by Luis Aparisi, form Hospital Clnico Universitario studied the possible association between CP and LC of alcoholic etiology. They compared clinical, functional, morphological and biochemical parameters in alcoholic subjects with a definitive diagnosis of CP or LC and this will be published on October 28, 2008 in the World Journal of Gastroenterology.

In their study, one hundred and forty consecutive alcoholic patients were subdivided into three groups: CP (n = 53), LC (n = 57), and asymptomatic alcoholic (n = 30). Clinical, biochemical and morphological characteristics, Child-Pugh index, indocyanine green test, and fecal pancreatic elastase-1 test were assessed.

They found that in patients with cirrhosis, major clinical manifestations of CP such as pancreatic pain and steatorrhoea as well as imaging alterations of CP such as calcifications, duct dilation and pseudocysts were absent; insulin-dependent diabetes was present in 5.3% cases, and elastase-1 test was altered in only 7% and severely altered in none. In patients with CP, clinical characteristics of cirrhosis such as ascites, encephalopathy and gastrointestinal haemorrhage were present in one case, Child-Pugh grade > A in 5.7%, and altered indocyanine green test in 1.9% cases. In asymptomatic alcoholism, there was only a non-coincident alteration of elastase-1 test and indocyanine test in 14.8% and 10%, respectively, but other characteristics of cirrhosis or CP were absent. An inverse correlation (r = -0.746) between elastase-1 test and indocyanine test was found in alcoholic patients.

Their result indicated that there was a scarce coincidence in clinical and morphological alterations among patients with CP or LC of alcoholic etiology, but an inverse correlation between pancreatic and liver function tests. These findings support that these alcoholic diseases evolve in a different manner and have different etiopathogeny.


'/>"/>
Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Fairbank Farms Voluntarily Recalls 85% Ground Round Beef Patties Sold Fresh from Shaws Due to Possible Health Risk
2. M.D. Anderson-led team reports possible key to autoimmune disease
3. AHRQ and FDA to Collaborate in Largest Study Ever of Possible Heart Risks with ADHD Medications
4. Possible safer target for anti-clotting drugs found
5. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
6. Why it is impossible for some to just say no
7. Saving Millions of Childrens Lives Is Possible
8. Mayo Clinic Proceedings article explores possible link between obesity and viral infections
9. Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer
10. Help for California Fire Evacuees Possible Through Partnership for Prescription Assistance
11. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... DC (PRWEB) , ... March 23, 2017 , ... News ... Dental Choice has helped score a major victory in Europe for public health and ... , Based on rigorous scientific research and the overwhelming support of European ...
(Date:3/23/2017)... ... March 23, 2017 , ... “A Respectful Response To ... Response To Atheist Manifesto” is the creation of published author Richard Hostetter, a ... sixty years. He holds graduate degrees from Kent State University and the University ...
(Date:3/22/2017)... ... March 22, 2017 , ... Cosmetic Town, an ... issue of its companion print magazine. The new magazine, scheduled for release in ... information provided by board-certified doctors from across the country. , According to the ...
(Date:3/22/2017)... ... ... Old School Labs™, makers of the best-selling Vintage line of natural sports ... who trained with Floyd Mayweather, made his professional debut in London in 2003 and ... number of wins in contests in Britain, Germany and the U.S. , “We ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... today announced that its digital marketing solutions have enabled Children’s Hospital of The ... 24 months. , Recognizing the value of a digital marketing approach, the ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 TapImmune, ... specializing in the development of innovative peptide and ... metastatic disease, today announced that it will participate ... Dr. Glynn Wilson , Chairman and ... the company,s business, clinical pipeline and partnering opportunities ...
(Date:3/22/2017)... 22, 2017 Piramal Pharma Solutions ... held a special event to introduce the new and ... Lexington, Kentucky . The inaugural event was attended ... Ajay Piramal, and Piramal Pharma Solutions CEO, ... ...
(Date:3/22/2017)... ROCHESTER, N.Y. , March 22, 2017 /PRNewswire/ ... Steriliz R-D™ Rapid Disinfector™ is the proven ultraviolet-C ... that cause healthcare-associated infections (HAIs). ... American Journal of Infection Control , the peer-reviewed ... testing and experiences of Vancouver General Hospital and ...
Breaking Medicine Technology: