Navigation Links
Possible Cause of Postpartum Depression Pinpointed
Date:7/30/2008

y after delivery. As a result, neurosteroid levels also rise and fall.

Maguire and Mody wanted to see what happens to GABA receptors in the brains of mice undergoing the hormonal swings associated with pregnancy. By comparing virgin, pregnant and postpartum mice, the pair discovered that GABA receptor abundance (and function) falls during pregnancy and then returns to pre-pregnancy levels following birth.

That makes sense from a homeostatic point of view, Maguire explained. For the body to maintain a constant level of GABA receptor-derived inhibition, receptor abundance must stay more or less in synch with neurosteroid levels.

"If you want to maintain a constant level of inhibition, with more neurosteroids, you need fewer receptors," she explained. "After pregnancy, when hormone levels drop off, you need more receptors to maintain that level. If you cannot maintain that level after pregnancy, that's when the disorders manifest."

She and Mody reached that conclusion using mice genetically engineered to lack a particular component of the GABA receptor -- that is, mice that cannot adjust GABA receptor levels in response to changing hormone levels. By comparing these mutants to normal mice, the pair discovered that dysregulation of the normal changes in GABA receptor levels lead to mouse behaviors akin to postpartum depression, such as anxiety and depression, with a concomitant decrease in pup survival.

Treatment with THIP (Gaboxadol), a GABA receptor agonist originally intended to treat sleep disorders, ameliorated these effects in mice containing decreased levels of GABA receptors.

"Our thinking is that postpartum depression, and maybe premenstrual syndrome and premenstrual dysphoric disorder, may be due to impaired trafficking of these [GABA] receptors to the [neural] membrane," Mody said.

The next step, he said, is to determine whether human postpartum depression is caused by a similar defect.'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Searching for shut eye: Penn study identifies possible sleep gene
2. AUDIO OF CONFERENCE CALL: National Disability Rights Leaders Dubious Over John McCains Possible Switch on Community Choice Act, Says DNC
3. Booster vaccination may help with possible future avian influenza pandemic
4. Possible link found between X-rays and prostate cancer
5. Pediatric researchers find possible master switch gene in juvenile arthritis
6. US Drug Watchdog Expands Its National Investigation Into The Drug Called Digitek, And Would Like To Talk To Possible Victims
7. Star-Shaped Brain Cells Make Scans Possible
8. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
9. Possible biological explanation for C-Section-linked allergies and asthma found
10. Blood test for lung cancer may be possible
11. WorldHeart Announces Possible Delisting Action by NASDAQ
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Possible Cause of Postpartum Depression Pinpointed
(Date:8/21/2014)... August 22, 2014 Top10BestSEOHosting.com has ... announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is one ... 2014. , The manager of Top10BestSEOHosting.com states, ... hosting supplier. Actually, these companies have outperformed their ... customer support. People can get the best web ...
(Date:8/21/2014)... August 21, 2014 Living in a ... atmosphere that comes along with it. A quality Home ... that such amenities are available. , ... Fayetteville, Georgia and Community Association Management, LLC made a ... Parks Company to provide an additional amenity for their ...
(Date:8/21/2014)... chronic kidney disease patients may be a strong indicator ... in the Journal of the American Society of ... Hopkins Bloomberg School of Public Health assert that coronary ... atherosclerosis in predicting the risk of heart disease among ... all patients with chronic kidney disease (CKD) die from ...
(Date:8/21/2014)... Dallas, TX (PRWEB) August 21, 2014 ... August 20 entertained residents with dementia at Silverado Turtle ... Improv Troupe, which consists of entertainers ranging from ages ... each time they perform their 40-minute set. The troupe's ... makes it universal and allows them to touch audiences ...
(Date:8/21/2014)... California (PRWEB) August 21, 2014 The ... initial plans for entertainment and programming for its inaugural ... On Sunday, October 12, 2014, from 11 a.m. to ... closed to all cars and the downtown will be ... activities, curated by Community Arts Resources (CARS), for all ...
Breaking Medicine News(10 mins):Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4
... software suite ensures that Builders Benefits is ready and ... , , BURLINGTON, Mass., June 23 HealthEdge, ... healthcare payors, today announced that Pennsylvania-based Builders Benefits has ... The advanced technology of HealthRules will now be used ...
... Scientists ... our brains function depending on whether we,re early risers or night owls. , ... (Vocus) June 23, 2009 -- Are you ... found that there are significant differences in the way our brains function depending on whether ...
... Solution Approach Catapults Company to Leadership Status in Providing Healthcare ... InfoLogix, Inc. (Nasdaq: IFLG ... the healthcare and commercial industries, announced today that the company ... the top ten consulting companies in healthcare IT ...
... Reasons for racial disparity remain unclear, researcher says, , TUESDAY, ... rare bone and soft tissue cancer Ewing,s sarcoma disproportionately strikes ... disease, males are more likely to die from it than ... Cancer . , Led by Dr. Sean Scully of ...
... June 23 The Certification Commission for Healthcare Information ... CCHIT Certified(R) 08 Ambulatory EHR, and meets 100% of ... "seal of approval" for EHR products provides a consensus-based, ... products with the CCHIT Certified(R) seal, physicians and other ...
... use Entrust grid cards, tokens and one-time-passcodes for strong ... 23 Healthcare networks and facilities rely on security ... have access to it. Importantly, this is no different ... make it possible. In fact, Entrust, Inc. (Nasdaq: ...
Cached Medicine News:Health News:Builders Benefits and HealthEdge(R) Complete Implementation of Award-Winning HealthRules(R) Product Suite 2Health News:Morning People and Night Owls Show Different Brain Function: University of Alberta Study 2Health News:InfoLogix Ranked as 7th Leading Consulting Company in Healthcare IT 2Health News:InfoLogix Ranked as 7th Leading Consulting Company in Healthcare IT 3Health News:Whites More Likely to Get Rare Bone Cancer 2Health News:The Criterions Medical Suite EHR 1.0.0 Receives 08 CCHIT Certification 2Health News:The Criterions Medical Suite EHR 1.0.0 Receives 08 CCHIT Certification 3Health News:Austrian IT Solutions Provider x-tention IT GmbH Implements Entrust Versatile Authentication Platform 2Health News:Austrian IT Solutions Provider x-tention IT GmbH Implements Entrust Versatile Authentication Platform 3
(Date:8/21/2014)... N.J. , Aug. 21, 2014  Armada ... group purchasing organization (GPO), is pleased to announce ... collaborate on a host of innovative specialty pharmacy ... Aurora deliver enhanced therapy management services to specialty ... (OTM) system. Aurora will use the ...
(Date:8/21/2014)... N.Y. , Aug. 21, 2014  The board ... ), a leading provider of clinical trial imaging solutions, ... been named chief financial officer, effective immediately.  Mr. Groff ... since August 2013.  He joined VirtualScopics in January 2006 ... in February 2013. "When the board of ...
(Date:8/21/2014)...   Royal Philips (NYSE: ... received 510(k) clearance from the U.S. Food and ... for Transcatheter Aortic-Valve Implantation (TAVI) treatments. Through 3D ... pre-procedural, high-precision positioning to treat aortic stenosis ailments.  ... available as part of Philips IntelliSpace Portal ...
Breaking Medicine Technology:Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3
... 15, 2010 While many clinicians ... treatment of cancer, advances in technology along with ... International Conference of the Novalis Circle, have fueled ...   "Radiosurgery is certainly not new ...
... 2010 /PRNewswire/ -- PharmaNet Development ... services to the pharmaceutical, biotechnology, generic drug, and medical ... new brand identity and tagline, "PharmaNet Works For You". ... to its clients to provide intelligent solutions to accelerate ...
Cached Medicine Technology:New Stereotactic Body Radiation Therapy (SBRT) Protocols Fuel Interest in Advanced Lung and Liver Treatments 2New Stereotactic Body Radiation Therapy (SBRT) Protocols Fuel Interest in Advanced Lung and Liver Treatments 3New Stereotactic Body Radiation Therapy (SBRT) Protocols Fuel Interest in Advanced Lung and Liver Treatments 4PharmaNet Launches New Brand Identity at Upcoming Industry Conferences 2
Serrated rake tip spatula with 20 gauge shaft. Black finish for reduced glare. Can be used with 20 gauge MVR blades....
Rounded tip spatula with 20 gauge shaft. Black finish for reduced glare....
Smooth, blunt round spatula for manipulations of the corneal flap. Ideal for placement under the flap to expose the stromal interface....
Triangular 0.5 mm angled tip with 4 mm flat surface. Round knurled handle with dull finish. Tip angle: 150o....
Medicine Products: