Navigation Links
'Positive stress' helps protect eye from glaucoma
Date:4/3/2012

essure of the fluid that fills the eye. The only treatments for glaucoma are drugs that reduce this pressure; there are no therapies designed to protect the retina and optic nerves from harm.

Scientists classify glaucoma as a neurodegenerative disease based on how slowly and progressively it kills retinal ganglion cells. The bodies of these cells are located in the retina of the eye; their branches or axons come together in bundles and form the optic nerves. Scientists don't know if damage begins in the bodies or axons of the cells, but as more and more retinal ganglion cells die, patients experience peripheral vision loss and eventually become blind.

For the new study, Yanli Zhu, MD, research instructor in neurosurgery, induced glaucoma in mice by tying off vessels that normally allow fluid to drain from the eye. This causes pressure in the eye to increase. Zhu then assessed how many cell bodies and axons of retinal ganglion cells were intact after three or 10 weeks.

The investigators found that normal mice lost an average of 30 percent of their retinal ganglion cell bodies after 10 weeks of glaucoma. But mice that received the preconditioning before glaucoma-inducing surgery lost only 3 percent of retinal ganglion cell bodies.

"We also showed that preconditioned mice lost significantly fewer retinal ganglion cell axons," Zhu says.

Gidday is currently investigating which genes are activated or repressed by preconditioning. He hopes to identify the changes in gene activity that make cells resistant to damage.

"Previous research has shown that there are literally hundreds of survival genes built into our DNA that are normally inactive," Gidday says. "When these genes are activated, the proteins they encode can make cells much less vulnerable to a variety of injuries."

Identifying specific survival genes should help scientists develop drugs that can activate them, according to Gidday.

Neurologis
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pregnancy is safe for women with estrogen receptor positive breast cancer
2. Queens professor urges health research to focus on the positive
3. Positive parenting during early childhood may prevent obesity
4. Positive Reinforcement May Help Patients Take Their Meds
5. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
6. Standard treatments for head and neck cancer less effective in HIV-positive patients
7. Rutgers study finds paid family leave leads to positive economic outcomes
8. Parkinsons treatment shows positive results in clinical testing
9. Combination therapy shows positive response for children with ADHD
10. Positive feedback and tumorigenesis
11. Proteins do not predict outcome of herceptin treatment in HER2-positive breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... PA (PRWEB) August 27, 2014 What’s ... of this year’s 87th Annual Scripps National Spelling Bee? ... for a tour of internationally renowned Wills Eye Hospital.     ... like to be an ophthalmologist one day. , Wills ... eye surgery and the latest hi-tech visual diagnostic testing. ...
(Date:8/27/2014)... NC. SonaCare Medical, LLC, the global leader in ... 15 HIFU devices over the past twelve months pointing ... company’s ablation technology. , “It is truly exciting ... the past year, especially since we are now heading ... active sales period,” says Mike Klein, CEO of SonaCare ...
(Date:8/27/2014)... -- A new study finds that continuous positive airway ... sleep apnea. CPAP is widely used to treat ... which the airway relaxes and narrows during sleep, causing ... daytime drowsiness. CPAP keeps the airway open ... nose via a mask that is worn during sleep. ...
(Date:8/27/2014)... (HealthDay News) -- Overconfident people are better at convincing ... and therefore are more likely to get promotions and ... researchers added that these "self-deceived" people are also more ... greater risks. And finally, people who underestimate themselves ... to the British researchers. Their findings were published Aug. ...
(Date:8/27/2014)... each receive $100,000 in funding to launch pilot programs ... for patients served by community health centers. The program ... and is part of the group,s effort to reach ... over receiving regular screening for colorectal cancer by 2018. ... are: Port Royal, South Carolina; New Haven, Connecticut; and ...
Breaking Medicine News(10 mins):Health News:Scripps National Spelling Bee Co-Champion and Aspiring Ophthalmologist Coming to Wills Eye Hospital in Philadelphia 2Health News:SonaCare Medical Announces Twelve Months Sales Results of Fifteen HIFU Devices 2Health News:Sleep Apnea Treatment Helps Seniors, Study Finds 2Health News:Overconfident Folks May Blind Others to Their Real Abilities 2Health News:Pilot program aims to improve cancer screening, specialty care in community health centers 2Health News:Pilot program aims to improve cancer screening, specialty care in community health centers 3
... -- Poor memory and problems with other mental skills may be ... suggests. Researchers gave a word recall memory test to 17,851 ... to measure the brain,s executive functioning skills. The participants, who were ... a stroke, were then contacted twice a year for up to ...
... source of cocaine, is speeding up destruction of rainforests ... and animal diversity, scientists are reporting in a new ... for establishing larger protected areas to help preserve biodiversity, ... . Liliana M. Dvalos and colleagues note ...
... By Amanda Gardner HealthDay Reporter , TUESDAY, Feb. ... necessary in women with early breast cancer who also undergo a ... in the Feb. 9 issue of the Journal of the ... sentinel nodes -- those lymph nodes to which the cancer spreads ...
... study from Utrecht and Cambridge Universities has for the ... the tongue in volunteers negatively affects a person,s ability ... findings are published this week in the journal ... addition, the effects of testosterone administration are predicted by ...
... University medical device startup that has developed a system ... closing the beating heart during cardiac surgery has received ... the Georgia Tech/Emory technology and will further develop the ... procedure required for delivering therapeutic devices to the heart ...
... -- An injection of local anesthetic can be made ... researchers report. They reviewed 18 studies that included ... injections led to a "clinically meaningful reduction in pain," ... not; whether the shot was administered subcutaneously (under the ...
Cached Medicine News:Health News:Could Poor Memory Signal Raised Stroke Risk? 2Health News:Cocaine production increases destruction of Colombia's rainforests 2Health News:Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study 2Health News:Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study 3Health News:Extra testosterone reduces your empathy 2Health News:Apica Cardiovascular receives $5.1 million investment for improved heart surgery system 2Health News:Apica Cardiovascular receives $5.1 million investment for improved heart surgery system 3
(Date:8/27/2014)... , Aug. 27, 2014 /CNW/ - Covalon Technologies Ltd. (the ... announces the following financial results for its third quarter of ... 30, 2014: , Revenue of $1,291,378, a 13% ... , Net loss for the quarter of $240,156 compared to ... prior year For the nine months ended ...
(Date:8/27/2014)... 27, 2014  After the February 2014 launch of ... solution for medical practices and management companies, Prime ... new software. "The feedback has been great," ... "The sheer number of demos and new sign-ups is ... for these types of software features." ...
(Date:8/27/2014)... , Aug. 27, 2014 Sinovac Biotech Ltd. (NASDAQ: ... China , today announced the results of the Company,s ... 2014 in Beijing , PRC. The required quorum, ... The Company,s shareholders approved the following proposals:  ... Lam Lo , Simon Anderson , Kenneth Lee ...
Breaking Medicine Technology:Covalon Announces Third Quarter Results 2Covalon Announces Third Quarter Results 3Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 3Sinovac Announces Results of 2014 Annual General Meeting of Shareholders 2
... derivative compound series,show highly selective PI3K-inhibition which ... 16, 2007 /PRNewswire-FirstCall/ - AEterna Zentaris,Inc. , ... on,endocrine therapy and oncology, today presented an ... pyridopyrazine derivatives,with high selectivity for PI3K inhibition, ...
... With Improved Potential to,Battle Their Disease, PASADENA, ... Inc., a majority-owned subsidiary of Arrowhead,Research Corporation ... will be featured in a poster presentation ... (AACR) Annual,Meeting. In particular, this poster includes ...
Cached Medicine Technology:AEterna Zentaris Discloses First In Vitro Data for its PI3K,Inhibitors at the AACR Annual Meeting in Los Angeles 2AEterna Zentaris Discloses First In Vitro Data for its PI3K,Inhibitors at the AACR Annual Meeting in Los Angeles 3Poster on Cyclosert Drug Delivery Presented at AACR Meeting 2Poster on Cyclosert Drug Delivery Presented at AACR Meeting 3Poster on Cyclosert Drug Delivery Presented at AACR Meeting 4
... Collection was inspired by the professional male who ... be appreciated by all men especially those between ... incorporates a complete range of materials, shapes and ... advantage of the best that fashion and technology ...
Hush Puppies Pups feature vibrant colors and playful styling for children. Kids love the added comfort while parents love the durable designs found in every Hush Puppies Pups frame....
... and playful, the Thalia ... for girls who love ... colorful accents and sparkling ... this exciting collection.Thalia Girls ...
... updated shapes and traditional colors in their eyewear. ... to wear deigns in rectangles and teacup shapes. ... of metal fronts and zyl temples. Frames feature ... added comfort and exceptional fit., ,Building on the ...
Medicine Products: