Navigation Links
Positive Results for Ophthotech's Novel Therapy for Wet AMD - Study of Anti-PDGF and Anti-VEGF Therapy Shows Significant Neovascular Regression and Enhanced Visual Outcome
Date:5/4/2009

itive to an anti-VEGF attack.

"The objective and robust response of neovascular regression is consistent with the biologic activity of E10030. I look forward to a randomized trial design to confirm the strong proof of concept data of this study," said Dr. Donald J. D'Amico, Professor and Chairman, Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital.

"It is exciting to see our clinical trial confirm the strong preclinical data from oncology and ophthalmic studies targeting the molecules regulating pericyte and endothelial cell survival. Ophthotech will continue to devote its resources towards an accelerated development of our anti-PDGF compound," said Dr. Samir C. Patel, President and CEO of Ophthotech Corp.

Wet AMD is characterized by the abnormal growth of blood vessels (neovascularization) beneath the retina, which leak blood and fluid and can cause permanent damage to cells in the center of the retina (the macula). This form of AMD is the most severe form of the disease, and often leads to permanent vision loss.

E10030 is one of three compounds that Ophthotech is developing to treat wet and dry AMD. Additional molecular entities include an anti-C5 aptamer and volociximab, an anti-angiogenic monoclonal antibody targeting the a5B1 integrin, both currently in a Phase I study.

About anti-PDGF E10030

E10030 is an aptamer-based compound directed against PDGF-B. Pharmacology studies indicate that E10030 binds to PDGF-B with high specificity and affinity and inhibits the functions of PDGF-B both in vitro and in vivo. In preclinical studies, E10030 demonstrated the potential to regress neovascularization when used in combination with a VEGF-A inhibitor. In experiments involving models of ocular vascularization, concurrent inhibition of PDGF-B and VEGF-A signaling was superior to inhibition of the VEGF-A pathway alone.'/>"/>

SOURCE Ophthotech Corp.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. VIA Pharmaceuticals Announces Positive Phase 2 Results of VIA-2291 in Cardiovascular Patients Using Serial MDCT Imaging of Coronary Plaque
2. Unexpected Positive Finding Expands Potential for Quigley QR333 Drug for Diabetic Neuropathy; Findings Suggest Possible Disease Modification
3. HIV positive and HIV negative patients have similar survival rates following liver transplant
4. The ALS Association's 'ALS Across America' Focuses On Staying Positive and Involved
5. Sirion Therapeutics Announces Positive Results From Interim Analysis of Phase II Trial and Receives FDA Fast Track Designation for Fenretinide
6. Arena Pharmaceuticals Announces Positive Lorcaserin Pivotal Phase 3 Obesity Trial Results: Meets All Primary Efficacy and Safety Endpoints
7. Economy Got You Down? Use The Principles Of Positive Psychology
8. Standard and Poors Raises Boston Scientifics Rating Outlook to Positive
9. Recent Industry Developments Reaffirm Positive Glucose Industry Outlook
10. Cepheid Receives Health Canada License for First On-demand Diagnostic Test for Life-threatening MRSA and S. aureus Infections From Patient Positive Blood Culture Bottles
11. Marinus Pharmaceuticals, Inc. Announces Positive Results of its Phase 2 Clinical Trial of Ganaxolone as Adjunctive Therapy in Adults With Partial Onset Seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... (PRWEB) September 22, 2014 Airbus Helicopters ... industry Monday for their efforts to improve safety and ... Award and the Program of the Year award, both ... Air Medical Transport Conference Annual Community Awards. , ... with the Jim Charlson Aviation Safety Award, given annually ...
(Date:9/22/2014)... September 22, 2014 Starbrite Dental ... patients who require orthodontic work. Six-Month Smiles is designed ... deserve in a fast and effective way. , Many ... extremely daunting. Having to wear metal braces for several ... and spend time keeping the braces clean, is undesirable ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 United ... all of the federal mesh lawsuits ( http://www.meshinjurylawfirm.com/lawsuits/ ... have been consolidated for pretrial matters, issued an ... Corp. Pelvic Repair System Products Liability Litigation (United ... West Virginia; Case no. 2:12-md-02326)—requiring that four member ...
(Date:9/22/2014)... more and drink more , Study used smartphones to ... differ from past research on physical activity and exercise ... that on days when people exercise more -- typically ... , This is the only study to use smartphone ... activity and alcohol use. , "Monday through Wednesday people ...
(Date:9/22/2014)... and young adults at risk for sexually transmitted infections ... sexual behaviors, according to new recommendations from the U.S. ... million new sexually transmitted infections such as gonorrhea and ... people between 15 and 24 years old, according to ... Sept. 22 in Annals of Internal Medicine , ...
Breaking Medicine News(10 mins):Health News:Airbus Helicopters Inc. Honors Leaders in Air Medical Industry 2Health News:Airbus Helicopters Inc. Honors Leaders in Air Medical Industry 3Health News:Starbrite Dental Introduces Six-Month Smiles 2Health News:Federal Court Sets Trial Date for Boston Scientific Vaginal Mesh Cases in Florida, the Rottenstein Law Group LLP Reports 2Health News:We drink more alcohol on gym days 2Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 2Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 3
... statement,is being released by Sr. Carol Keehan, DC, ... Association of the United States (CHA):, The ... provided,today by the Holy See,s Congregation for the ... administered nutrition and,hydration to patients in a persistent ...
... Pharmaceuticals,Inc. (Nasdaq: AMLN ) management will be presenting ... Annual Meeting of the European,Association for the Study of ... PT / 1:30 p.m. CET local time in Amsterdam, ... recordings will be made,available following the event. The webcast ...
... Sept. 13 (HealthDay News) -- It,s under your movie seat ... , But relief may be in sight. This week, researchers ... chewing gum at the BA Festival of Science in York, ... clothes, hair and sidewalks, and preliminary tests indicate that it ...
... Mich., Sept. 14 Stryker,Corporation (NYSE: SYK ) ... conference: September 25, 2007 - 4:30 p.m. Eastern ... York, New York A simultaneous webcast of the ... http://www.stryker.com via the For Investors page. The,presentation for ...
... Sept. 14 Mylan Laboratories Inc.,(NYSE: MYL ... Lacerca to the,position of Senior Vice President and ... from Bristol-Meyers Squibb where she was,Director of Compliance ... she was responsible for all compliance-related matters in ...
... WASHINGTON, Sept. 14 - The successful,implementation of electronic ... program $1.2 million per month according to a ... and increased quality,demonstrated in Mississippi reinforces the importance ... Management Association,(PCMA) said today., "The state of ...
Cached Medicine News:Health News:Comment Regarding Congregation for the Doctrine of Faith Clarification Concerning Nutrition and Hydration for Patients in a Persistent Vegetative State 2Health News:Stryker to Present at Investor Conference 2Health News:Mylan Announces Appointment of M. Fabiana Lacerca as Senior Vice President and Chief Compliance Officer 2Health News:E-Prescribing Saving Mississippi Medicaid $1.2 Million Per Month 2
(Date:9/22/2014)... , Sept. 22, 2014 ... the U.S. commercial launch of its foot plating system ... Paragon 28.  The GORILLA TM R3CON PLATING SYSTEM ... the Monster TM & Mini-Monster TM Screw ... Comprised of 10 interchangeable subsystems, the GORILLA TM ...
(Date:9/22/2014)... Research and Markets ( ... the  "Global Remotes Market 2014-2018"  report to ... Remotes/remote controls are devices that ... such as smart TVs, set top boxes, ... distance. Remote controls are small wireless handheld ...
(Date:9/22/2014)... -- Final shortlist announced, winners to ... The second edition of the much-awaited VCCircle Healthcare Awards is round ... final nominations for the 2014 honours.  The names of ... 25 at The Taj Mahal Palace, Mumbai . The ... variety of qualitative and quantitative parameters - such as ...
Breaking Medicine Technology:Paragon 28, Inc. Launches the GORILLA(TM) R3CON PLATING SYSTEM 2Global Remotes Market 2014-2018 2Global Remotes Market 2014-2018 3Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 2Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 3
... LYON, France, May 11, 2012 Mylan Inc. (Nasdaq: ... launched Atorvastatin Calcium Tablets, 10 mg, 20 mg, 40 ... the Netherlands and Ireland. Mylan has received marketing authorization ... its product immediately. Atorvastatin Calcium is the generic version ...
... /PRNewswire-iReach/ -- Electrochemical Oxygen Concepts (EO2™ ... chronic wound treatment device, announced it has been ... Federal Supply Schedule (FSS) contract, administered by The ... ® , a noninvasive, electrochemical low-dose tissue oxygenation ...
Cached Medicine Technology:Mylan Launches Generic Lipitor® in Five European Countries 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 3
... Graham-Field has been developing diverse ... 58 years. Our medical-surgical products ... for innovation, quality and customer ... include the Labtron® line of ...
... spill-proof design and effective output, even when ... medical nebulizers are free-standing for easy preparation., ... available., ,All Portex® medication nebulizer products ... feature consistently fine misting and the efficient ...
... a spill-proof design and effective output, even ... All medical nebulizers are free-standing for easy ... are available., ,All Portex® medication nebulizer ... nebulizers feature consistently fine misting and the ...
... with metered dose inhalers., ,ACE ensures ... MDI canisters. Its versatile design allows it ... in conjunction with an endotracheal airway or ... ACE may also be used in conjunction ...
Medicine Products: