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Positive Results From Peregrine Pharmaceuticals' Bavituximab Phase l HCV Trial Presented at AASLD Meeting
Date:11/5/2007

- Bavituximab Appeared Generally Safe and Well Tolerated at All Doses

Tested -

- Signs of Anti-viral Activity Seen at All Dose Levels - - Exploratory Analysis of Cytokine Profile Following Treatment Supports

Proposed Immunomodulatory Mechanism of Action -

TUSTIN, Calif. and BOSTON, Nov. 5 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a biopharmaceutical company developing monoclonal antibodies for the treatment of cancer and hepatitis C virus (HCV) infection, today announced that results from its Phase lb study of bavituximab in chronic HCV patients were discussed on Sunday in an oral presentation at the 58th Annual Meeting of the American Association for the Study of Liver Disease (AASLD) -- The Liver Meeting(R). The study results were presented by Dr. Eric J. Lawitz, a principal investigator of the Phase lb study and director of Alamo Medical Research.

The multiple dose, open label study was designed to assess the safety and pharmacokinetic properties of ascending dose levels of bavituximab administered as monotherapy in patients with chronic HCV infection. Other study objectives included evaluation of anti-viral activity as measured by changes in serum HCV virus levels and an exploratory analysis of changes in serum cytokine levels as a measure of bavituximab's ability to stimulate certain components of the immune system.

Results indicate that bavituximab was generally safe and well tolerated, with no dose limiting toxicities or serious adverse events reported. Anti-viral activity (decline of greater than or equal to 0.5 log10 reduction in HCV RNA) was observed at all dose levels and was most consistent i
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SOURCE Peregrine Pharmaceuticals
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