Navigation Links
Portuguese scientists discover new mechanism that regulates formation of blood vessels
Date:11/17/2008

Researchers in one of the external groups of the Instituto Gulbenkian de Cincia (IGC), in Portugal, have discovered a novel mechanism which regulates the process whereby new blood vessels are formed and wounds heal, including chronic wounds, such as those found in diabetic patients and those suffering from morbid obesity. These findings, by Srgio Dias and his team, are to appear in the new issue of the journal PLoS ONE(*), and have implications for the development of new therapeutic approaches to healing damaged blood vessels and building new ones.

Working at the Centro de Investigao e Patobiologia Molecular of the Portuguese Institute of Oncology Francisco Gentil, in Lisbon, the team showed that the cells that make new blood vessels (called endothelial cells) are stimulated by an intracellular signalling pathway, mediated by the protein Notch.

The formation of new blood vessels is a crucial step in wound healing: the newly-formed vessels allow anti-inflammatory proteins to reach the wound site, improve oxygenation of the damaged tissue and carry essential nutrients for the re-structuring of the tissue, that is, the skin.

According to Francisco Caiado, a PhD student at the IGC, and first author of this study, "We knew that the endothelial cells are stimulated by cells originating in the bone-marrow, the so-called bone-marrow derived precursor cells. We have now shown that the actual stimulus happens through the Notch protein, found on the bone-marrow derived cells. Upon activation, Notch promotes the adhesion of the precursor cells to the site of the lesion, where they stimulate the endothelial cells to make new blood vessels".

Chronic skin wounds are an increasing medical problem, since they are commonly found in diabetic patients and in those suffering from morbid obesity. Diabetic patients may develop "diabetic foot", a condition whereby wounds do not heal leading, in the most severe cases, to amputation.


'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
35-121-440-7959
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related medicine news :

1. UCLA scientists find cell pathway driving a deadly sub-type of breast cancer
2. Leading Scientists From Around the World Headed to Kansas for Symposium on Combating Deadly Infectious Diseases
3. Cardiff scientists study acute infection in end-stage kidney disease patients
4. Scientists Unravel Mystery of Tamoxifen Resistance
5. Freezing Ovaries Preserves Fertility, Scientists Report
6. TSODs Frank Whyte Provides Negotiation Skills Training to NIH Scientists
7. Scientists Debate Dietary Supplements and Cancer Risk at AICR Conference
8. Penn scientists show how body determines optimal amount of germ-fighting B cells
9. Penn scientists map molecular regulation of fat-cell genetics
10. Scientists Make Clones of Mice Dead 16 Years
11. Anti-VEGF drugs for retinal diseases could have serious side effects, scientists caution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... Cary, NC (PRWEB) , ... May 04, 2016 , ... ... database in the world. The Duke Clinical Research Institute (DCRI) and analytics leader SAS ... of cardiovascular patient data collected by the Duke University Health System. , The ...
(Date:5/4/2016)... ... May 04, 2016 , ... All-Star Insurance of Northeast ... the people of their local community. The agency pledges to select a new ... hope is to bring awareness to important local causes with fundraising and other ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... May kicked ... in people across the United States. Dermatologist Dr. Ellen Turner is encouraging her patients, ... experts’ advice and focus on skin safety and health now and in the future. ...
(Date:5/4/2016)... ... 04, 2016 , ... Dr. Elyson and Dr. Assili, dentist in Northridge ... Wisdom tooth removal, a common dental procedure, is performed for many adolescents and young ... resulting in risks of complications. By providing wisdom tooth removal surgery at their office, ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nordic Naturals announces another ... metabolic health. This synergistic combination of omega-3 fatty acids and potent antioxidants contains ... of reduced glutathione and 200 mg of N-Acetylcysteine (NAC). , Each nutrient ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 ... and endovascular medical technology, today announced Food and ... a cardiac resynchronization defibrillator that provides heart failure ... (MRI) scans. Iperia devices also have remote monitoring ... (CLS) that adapts the heart rate in response ...
(Date:5/3/2016)... YORK , May 3, 2016 ... (MRI) Market Size, Share, Development, Growth and Demand Forecast ... Open), by Field Strength (High Field, Very High Field, ... Application (Brain, Head and Neck, Spine, Musculoskeletal, Vascular, Breast, ... the global magnetic resonance imaging (MRI) market was valued ...
(Date:5/3/2016)... 2016 Norgine B.V. ... einen entscheidenden Meilenstein durch diese Veröffentlichung zur  ... Handeln, um Patientenresultate  bei Verdauungs- und Lebererkrankungen ... im Verständnis der Hepatischen Enzephalopathie bei und ... Hepatische Enzephalopathie in der Öffentlichkeit zu schaffen ...
Breaking Medicine Technology: